Category: Biology of Aging
Fighting Osteoporosis Through Cellular Signaling
December 19, 2022
A paper published in Experimental Gerontology has detailed how a bacterially derived compound may be useful in fighting osteoporosis. Osteoblasts and osteoclasts Osteoblasts are cells that build bone, and osteoclasts
Phytocannabinoids and Skin Rejuvenation
December 16, 2022
The Journal Club returns for the last time this year at 12:00 Eastern on Tuesday 20th on the lifespan.io Facebook page. This month, Dr. Oliver Medvedik is taking a look
Exploring Autophagy to Fight AMD
December 15, 2022
Publishing in Free Radical Biology and Medicine, a team of Chinese researchers has investigated the potential role of autophagy in fighting oxidative stress and potentially staving off age-related macular degeneration
Size Matters in Cellular Aging
December 14, 2022
In a new review article published in Frontiers in Cell and Developmental Biology, researchers have suggested adding cellular enlargement to the hallmarks of aging [1]. Bigger is not always better
Genetically Enhancing T Cells to Fight Tumors
December 12, 2022
A team of researchers from multiple Japanese universities has found a way to genetically enhance T cells against solid tumors, as published today in Nature Biomedical Engineering. A focus on
Clearing Out Senescent Cells Rejuvenates Human Skin
December 9, 2022
Using a novel senolytic drug, scientists have successfully eliminated senescent cells in human skin transplanted into mice. The treatment led to prolonged skin rejuvenation [1]. Senescence and senolytics Senescent cells,
Activated Natural Killer Cells Used To Clear Senescent Cells
December 8, 2022
In a study recently published in Biochemistry and Biophysics Reports, researchers have shown that growing natural killer (NK) cells and re-introducing them back into the human bloodstream reduces senescence markers
The Intersection of Crypto, Gamification, and Longevity
December 8, 2022
Gamification, the concept of using gaming elements in a non-traditional setting, has long been criticized as at best, a banal pastime, and at worst, a devious manipulation tool employed by
Rapamycin Improves the Viability of Egg Cells
November 28, 2022
Researchers publishing in Aging have found that rapamycin, a molecule thoroughly researched for its effects on metabolism, improves the viability of egg cells (oocytes) grown in vitro. Another approach towards
Exercise Might Protect from Metastatic Cancer
November 25, 2022
In a new study published in the journal Cancer Research, Israeli scientists have found that by increasing the metabolic activity of healthy cells, exercise likely pitches them against cancer cells
Rapamycin extends life span & health span in mice & Daphnia
November 23, 2022
The Journal Club returns at 12:00 Eastern time, November 29th on our Facebook channel. Dr. Medvedik will be taking a look at the recent paper entitled “Rapamycin treatment during development
Nicotinamide Riboside May Make Existing Cancer Worse
November 22, 2022
A paper published in the journal Biosensors and Bioelectronics has caused a stir in the longevity community by showing that nicotinamide riboside (NR), a precursor to NAD+, makes tumors more
Correlation Between Cognitive Decline and Epigenetic Clocks
November 21, 2022
Researchers publishing in Aging have found a correlation between cognitive decline and measurements of epigenetic aging. Familiar epigenetic clocks For this study, the researchers used four familiar epigenetic clocks: the
Muscle Strength Associated with Oral Health
November 17, 2022
Researchers publishing in The Lancet have found a relationship between poor oral health and weaker muscles in people who are at least 70 years old. An established health link We
Arginase Inhibitor Improves “Leaky Gut” in Old Mice
November 15, 2022
According to a new study, the age-related increase in intestinal permeability that drives inflammation can be alleviated by inhibiting the enzyme arginase, a regulator of nitric oxide production [1]. Gut
Fighting Osteoporosis Through Cellular Signaling
December 19, 2022
A paper published in Experimental Gerontology has detailed how a bacterially derived compound may be useful in fighting osteoporosis. Osteoblasts and osteoclasts Osteoblasts are cells that build bone, and osteoclasts are cells that consume it. These two processes happen consistently and naturally in the human body.
Phytocannabinoids and Skin Rejuvenation
December 16, 2022
The Journal Club returns for the last time this year at 12:00 Eastern on Tuesday 20th on the lifespan.io Facebook page. This month, Dr. Oliver Medvedik is taking a look at a new paper that explores phytocannabinoids in the context of skin aging and rejuvenation. Phytocannabinoids
Exploring Autophagy to Fight AMD
December 15, 2022
Publishing in Free Radical Biology and Medicine, a team of Chinese researchers has investigated the potential role of autophagy in fighting oxidative stress and potentially staving off age-related macular degeneration (AMD). AMD, oxidative stress, and autophagy AMD comes in two major forms. In the nonexudative (dry)
Size Matters in Cellular Aging
December 14, 2022
In a new review article published in Frontiers in Cell and Developmental Biology, researchers have suggested adding cellular enlargement to the hallmarks of aging [1]. Bigger is not always better Different cell types are known to have different shapes and sizes, which are dictated by their
Genetically Enhancing T Cells to Fight Tumors
December 12, 2022
A team of researchers from multiple Japanese universities has found a way to genetically enhance T cells against solid tumors, as published today in Nature Biomedical Engineering. A focus on signals This highly in-depth paper begins with a discussion of signaling in the response of chimeric
Clearing Out Senescent Cells Rejuvenates Human Skin
December 9, 2022
Using a novel senolytic drug, scientists have successfully eliminated senescent cells in human skin transplanted into mice. The treatment led to prolonged skin rejuvenation [1]. Senescence and senolytics Senescent cells, also known as “zombie cells”, are cells that have stopped proliferating after being subjected to any
Activated Natural Killer Cells Used To Clear Senescent Cells
December 8, 2022
In a study recently published in Biochemistry and Biophysics Reports, researchers have shown that growing natural killer (NK) cells and re-introducing them back into the human bloodstream reduces senescence markers in a wide variety of immune cells. Peripheral blood mononuclear cells This research focuses on peripheral
The Intersection of Crypto, Gamification, and Longevity
December 8, 2022
Gamification, the concept of using gaming elements in a non-traditional setting, has long been criticized as at best, a banal pastime, and at worst, a devious manipulation tool employed by unscrupulous companies to acquire profit. However, supporters suggest the opposite: that gamification is a science that
Rapamycin Improves the Viability of Egg Cells
November 28, 2022
Researchers publishing in Aging have found that rapamycin, a molecule thoroughly researched for its effects on metabolism, improves the viability of egg cells (oocytes) grown in vitro. Another approach towards a known problem Decreased fertility in women occurs much more rapidly than other aspects of aging,
Exercise Might Protect from Metastatic Cancer
November 25, 2022
In a new study published in the journal Cancer Research, Israeli scientists have found that by increasing the metabolic activity of healthy cells, exercise likely pitches them against cancer cells in a battle for nutrients, which slows cancer progression [1]. Higher metabolic activity Physical activity provides
Rapamycin extends life span & health span in mice & Daphnia
November 23, 2022
The Journal Club returns at 12:00 Eastern time, November 29th on our Facebook channel. Dr. Medvedik will be taking a look at the recent paper entitled “Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna”[1]. Abstract Development is tightly
Nicotinamide Riboside May Make Existing Cancer Worse
November 22, 2022
A paper published in the journal Biosensors and Bioelectronics has caused a stir in the longevity community by showing that nicotinamide riboside (NR), a precursor to NAD+, makes tumors more aggressive in a mouse model [1]. Using a novel diagnostic tool In this new paper, the
Correlation Between Cognitive Decline and Epigenetic Clocks
November 21, 2022
Researchers publishing in Aging have found a correlation between cognitive decline and measurements of epigenetic aging. Familiar epigenetic clocks For this study, the researchers used four familiar epigenetic clocks: the first-generation Horvath and Hannum clocks along with the second-generation PhenoAge and GrimAge clocks, which are geared
Muscle Strength Associated with Oral Health
November 17, 2022
Researchers publishing in The Lancet have found a relationship between poor oral health and weaker muscles in people who are at least 70 years old. An established health link We have previously reported on the relationship between disease and oral health, specifically diabetes, and research has
Arginase Inhibitor Improves “Leaky Gut” in Old Mice
November 15, 2022
According to a new study, the age-related increase in intestinal permeability that drives inflammation can be alleviated by inhibiting the enzyme arginase, a regulator of nitric oxide production [1]. Gut feeling While age-related sterile inflammation (inflammaging) is considered one of the hallmarks of aging and a