Category: Biology of Aging
Intravenous Stem Cells Alleviate Guinea Pig Osteoarthritis
August 30, 2022
Scientists have shown that intravenous delivery of mesenchymal stem cells, which has some advantages over the more conventional intra-articular injection, alleviates age-related osteoarthritis and decreases inflammation in guinea pigs [1].
Researchers Propose Five New Hallmarks of Aging
August 29, 2022
Publishing in Aging five months after their panel discussion in Copenhagen, many well-known researchers have explained their reasons for wishing to add new hallmarks of aging to the existing paradigm.
Mitochondrial Drug Alleviates Atherosclerosis in Mice
August 26, 2022
Scientists have drastically improved various symptoms of atherosclerosis in mice by precisely targeting mitochondria with a plant-derived antioxidant [1]. Age-related and deadly Atherosclerosis, the accumulation of plaques on arterial walls,
Old Plasma Dilution Reduces Human Biological Age
August 26, 2022
The Journal Club returns to our Facebook page on Tuesday 30th August at 12:00 Eastern with your host, Dr. Oliver Medvedik. This month, we investigate a paper, Old plasma dilution
Plasma Dilution Appears to Rejuvenate Humans
August 25, 2022
Published in GeroScience, a groundbreaking study from the renowned Conboy lab has confirmed that plasma dilution leads to systemic rejuvenation against multiple proteomic aspects of aging in human beings. Systemic
Almost Half of Cancer Deaths Worldwide are Preventable
August 23, 2022
Researchers have shown that 44.4% of cancer deaths worldwide can be attributed to preventable risk factors, including behavioral and environmental ones [1]. Avoidable deaths It is well known that many
The Relationship Between Stroke and Inflammation
August 22, 2022
Publishing in Aging, a team of Chinese researchers has provided evidence showing a relationship between systemic inflammation and prognosis after a stroke. Stroke is a deadly and common affliction As
New Synthetic Molecule Alleviates Alzheimer’s in Mice
August 19, 2022
Scientists have synthesized a molecule that alleviates Alzheimer’s in a mouse model by targeting inflammation [1]. Aβ or inflammation? Two of the most prominent – and probably interconnected – symptoms
Combining Senolytic Pathways Has Synergistic Effects
August 18, 2022
A team of researchers have explained in Aging how multiple compounds that target the BCL-2 protein family are considerably more effective against senescent cells than each compound by itself [1].
Dietary Restrictions Do Not Help Cognitive Function in Mice
August 17, 2022
A new study published in Neurobiology of Aging has shown that neither caloric restriction nor intermittent fasting improve late-life cognition in genetically diverse mice, but the effect depends on genetic
Identifying Mitonuclear Genes for Longevity
August 17, 2022
Publishing in GeroScience, a team of researchers that included Nir Barzilai and Matt Kaeberlein examined genes that may affect both mitochondria and lifespan [1]. From the mitochondria to the nucleus
Rapamycin-Loaded Microneedles Reverse Hair Loss in Mice
August 16, 2022
Scientists have successfully regrown hair in a mouse model of hair loss using custom-made plastic microneedles loaded with rapamycin and epigallocatechin gallate (EGCG), an active ingredient in green tea [1].
Hypertension Is Associated with Brain Drainage Changes
August 11, 2022
Researchers publishing in Aging have found that enlarged perivascular spaces (ePVS) in the brain are correlated with vascular disorders [1]. These spaces, which are part of the brain’s glymphatic system,
An In-Depth Review of Skin Aging Genes
August 10, 2022
In a new systematic review published in Scientific Reports, multiple genes driving skin aging were identified [1]. The authors start by explaining the intrinsic (genetic and chronological) and extrinsic (environmental)
Scientists Move the Boundaries of Post-Mortem Recovery
August 9, 2022
Researchers have been able to achieve substantial recovery of cellular and organismal activity in pigs that had been dead for a full hour [1]. When is it too late? Advances
Intravenous Stem Cells Alleviate Guinea Pig Osteoarthritis
August 30, 2022
Scientists have shown that intravenous delivery of mesenchymal stem cells, which has some advantages over the more conventional intra-articular injection, alleviates age-related osteoarthritis and decreases inflammation in guinea pigs [1]. Systemic administration Osteoarthritis, a degenerative joint disease, is one of the most common causes of disability
Researchers Propose Five New Hallmarks of Aging
August 29, 2022
Publishing in Aging five months after their panel discussion in Copenhagen, many well-known researchers have explained their reasons for wishing to add new hallmarks of aging to the existing paradigm. A new addition to an old paradigm The Hallmarks of Aging, a well-cited and well-respected 2013
Mitochondrial Drug Alleviates Atherosclerosis in Mice
August 26, 2022
Scientists have drastically improved various symptoms of atherosclerosis in mice by precisely targeting mitochondria with a plant-derived antioxidant [1]. Age-related and deadly Atherosclerosis, the accumulation of plaques on arterial walls, is one of the deadliest age-related diseases. Atherosclerotic plaques, which consist mostly of cholesterol and fat,
Old Plasma Dilution Reduces Human Biological Age
August 26, 2022
The Journal Club returns to our Facebook page on Tuesday 30th August at 12:00 Eastern with your host, Dr. Oliver Medvedik. This month, we investigate a paper, Old plasma dilution reduces human biological age: a clinical study, in which Irina Conboy and her team investigated the
Plasma Dilution Appears to Rejuvenate Humans
August 25, 2022
Published in GeroScience, a groundbreaking study from the renowned Conboy lab has confirmed that plasma dilution leads to systemic rejuvenation against multiple proteomic aspects of aging in human beings. Systemic molecular excess This paper takes the view that much of aging is driven by systemic molecular
Almost Half of Cancer Deaths Worldwide are Preventable
August 23, 2022
Researchers have shown that 44.4% of cancer deaths worldwide can be attributed to preventable risk factors, including behavioral and environmental ones [1]. Avoidable deaths It is well known that many cancer cases occur due to behavioral and environmental and factors such as smoking and pollution, which
The Relationship Between Stroke and Inflammation
August 22, 2022
Publishing in Aging, a team of Chinese researchers has provided evidence showing a relationship between systemic inflammation and prognosis after a stroke. Stroke is a deadly and common affliction As the researchers point out, strokes are the leading cause of death in China, with strokes caused
New Synthetic Molecule Alleviates Alzheimer’s in Mice
August 19, 2022
Scientists have synthesized a molecule that alleviates Alzheimer’s in a mouse model by targeting inflammation [1]. Aβ or inflammation? Two of the most prominent – and probably interconnected – symptoms of Alzheimer’s disease are the accumulation of amyloid beta (Aβ) and chronic neuroinflammation. While the first
Combining Senolytic Pathways Has Synergistic Effects
August 18, 2022
A team of researchers have explained in Aging how multiple compounds that target the BCL-2 protein family are considerably more effective against senescent cells than each compound by itself [1]. The limitations of existing senolytics The researchers begin their paper with a familiar discussion of senescent
Dietary Restrictions Do Not Help Cognitive Function in Mice
August 17, 2022
A new study published in Neurobiology of Aging has shown that neither caloric restriction nor intermittent fasting improve late-life cognition in genetically diverse mice, but the effect depends on genetic composition [1]. Eat less, think better? Dietary interventions are known to have potential to extend lifespan
Identifying Mitonuclear Genes for Longevity
August 17, 2022
Publishing in GeroScience, a team of researchers that included Nir Barzilai and Matt Kaeberlein examined genes that may affect both mitochondria and lifespan [1]. From the mitochondria to the nucleus Over time, evolution has moved mitochondrial DNA from the individual mitochondria to the nucleus, where they
Rapamycin-Loaded Microneedles Reverse Hair Loss in Mice
August 16, 2022
Scientists have successfully regrown hair in a mouse model of hair loss using custom-made plastic microneedles loaded with rapamycin and epigallocatechin gallate (EGCG), an active ingredient in green tea [1]. A hairy problem While not life-threatening or debilitating, age-related hair loss (senescent alopecia) is one of
Hypertension Is Associated with Brain Drainage Changes
August 11, 2022
Researchers publishing in Aging have found that enlarged perivascular spaces (ePVS) in the brain are correlated with vascular disorders [1]. These spaces, which are part of the brain’s glymphatic system, allow for the drainage of potentially dangerous metabolites such as beta amyloid [2]. A known biomarker
An In-Depth Review of Skin Aging Genes
August 10, 2022
In a new systematic review published in Scientific Reports, multiple genes driving skin aging were identified [1]. The authors start by explaining the intrinsic (genetic and chronological) and extrinsic (environmental) factors that drive skin aging. While the environmental factors that affect the rate of skin aging,
Scientists Move the Boundaries of Post-Mortem Recovery
August 9, 2022
Researchers have been able to achieve substantial recovery of cellular and organismal activity in pigs that had been dead for a full hour [1]. When is it too late? Advances in resuscitation have already moved the boundaries of life and death, making it possible to revive