Category: Biology of Aging
Long-Term Cellular Reprogramming Causes Rejuvenation in Mice
March 11, 2022
Scientists have shown that in vivo partial cellular reprogramming can be safe and effective in an animal model, although the rejuvenation was mostly limited to long-term treatments and two tissue
Meat Consumption Increases Risk of Some Types of Cancer
March 10, 2022
In a new population study, scientists have found more evidence that consuming a lot of meat might not be a good idea, though the association between meat and cancer depends
SENS Researchers Culture Immune Cells to Fight Senescence
March 7, 2022
Publishing in Aging, a team of researchers from SENS Research Foundation has described a new method of enriching natural killer (NK) cells to fight senescent cells. Culturing NK cells to
Gut Viruses Found to Improve Cognition in Humans
March 3, 2022
A study published in Cell Host & Microbe has found that members of the Cuadovirales viral order positively affect cognition in multiple species, including humans. Viruses in the human body,
Carotid Bodies Play a Role in Glucose Regulation
March 2, 2022
An advance online preprint was recently released in Circulation Research examining carotid bodies’ role in hypertension and diabetes [1]. It will be published in the journal later this week. Drugs
Chloroquine Increases Maximum Lifespan in Rats by 13%
March 1, 2022
Scientists have shown that chloroquine, a well-known anti-malarial drug and the cousin of hydroxychloroquine, attenuates inflammation and fibrosis while significantly extending median and maximum lifespan in naturally aged rats [1].
Resveratrol Ameliorates Erectile Dysfunction in Old Rats
February 25, 2022
Scientists have shown that resveratrol rescues erectile function in aged rats, most probably by activating SIRT1, and that it can work in synergy with the existing erectile dysfunction treatment tadalafil
The Effects of Early Life Rapamycin Administration on Mice
February 24, 2022
A team of researchers, including Steve Horvath, Leonid Peshkin, and Vadim Gladyshev, has published a preprint on bioRxiv showing the effects of early administration of rapamycin over the lifespans of
NAD+ Levels Are Correlated with Physical Activity in Humans
February 22, 2022
In a study published in Nature Aging, a group of scientists has shown that NAD+ levels are correlated not only with age but with physical activity, with elder athletes rivaling
A New Understanding of Telomere Attrition
February 21, 2022
In Nature Cell Biology, a team of researchers has presented a current review of telomeres and how they relate to aging, reflecting modern research into a decades-old topic. Telomeres and
Caloric Restriction Promotes Rejuvenation in Human Trials
February 18, 2022
In a new paper, Yale scientists present encouraging data from an unprecedented human study of caloric restriction, a powerful anti-aging intervention [1]. Eat less, live more Despite all the might
A Fresh Examination of Epigenetic Clocks
February 17, 2022
In a preprint published in bioRxiv, Morgan Levine and colleagues have identified and grouped 5,717 epigenetic CpG sites into 12 different modules, conducting an in-depth examination into how epigenetic clocks
Muscular Oxidative Capacity Predicts Mobility Decline
February 16, 2022
Researchers publishing in Aging Cell have shown a relationship between mitochondrial dysfunction and mobility decline in older adults. A changing longitudinal study Since 1958, a team of researchers from the
New Treatment for Osteoarthritis Proposed
February 15, 2022
In a paper published in Nature Aging, a group of scientists outlines a previously unknown pathway that leads to osteoarthritis and describes a promising treatment [1]. Less than a killer,
New Partial Reprogramming Drastically Lowers Cellular Age
February 11, 2022
In a pre-print paper that has not yet been peer reviewed, a group of researchers presented a new highly efficient method of partial cellular reprogramming [1]. Young from old Our
Long-Term Cellular Reprogramming Causes Rejuvenation in Mice
March 11, 2022
Scientists have shown that in vivo partial cellular reprogramming can be safe and effective in an animal model, although the rejuvenation was mostly limited to long-term treatments and two tissue types [1]. There and back again Cellular reprogramming sounds like a technology from Star Trek, and
Meat Consumption Increases Risk of Some Types of Cancer
March 10, 2022
In a new population study, scientists have found more evidence that consuming a lot of meat might not be a good idea, though the association between meat and cancer depends on multiple factors [1]. Diet and health Given that lifestyle changes may be the only anti-aging
SENS Researchers Culture Immune Cells to Fight Senescence
March 7, 2022
Publishing in Aging, a team of researchers from SENS Research Foundation has described a new method of enriching natural killer (NK) cells to fight senescent cells. Culturing NK cells to fight senescence Previous experiments have shown that natural killer (NK) cells are partially responsible for the
Gut Viruses Found to Improve Cognition in Humans
March 3, 2022
A study published in Cell Host & Microbe has found that members of the Cuadovirales viral order positively affect cognition in multiple species, including humans. Viruses in the human body, but not human viruses Cuadovirales is an order of bacteriophages, which infect bacteria rather than animal
Carotid Bodies Play a Role in Glucose Regulation
March 2, 2022
An advance online preprint was recently released in Circulation Research examining carotid bodies’ role in hypertension and diabetes [1]. It will be published in the journal later this week. Drugs that target the glucagon-like peptide 1 (GLP1) receptor are widely used to treat type 2 diabetes
Chloroquine Increases Maximum Lifespan in Rats by 13%
March 1, 2022
Scientists have shown that chloroquine, a well-known anti-malarial drug and the cousin of hydroxychloroquine, attenuates inflammation and fibrosis while significantly extending median and maximum lifespan in naturally aged rats [1]. Fighting malaria since 1934 Chloroquine (CQ) was developed back in 1934 as an anti-malarial treatment and as
Resveratrol Ameliorates Erectile Dysfunction in Old Rats
February 25, 2022
Scientists have shown that resveratrol rescues erectile function in aged rats, most probably by activating SIRT1, and that it can work in synergy with the existing erectile dysfunction treatment tadalafil [1]. A molecule of discord Resveratrol, a plant-derived chemical of the polyphenol family, was once considered
The Effects of Early Life Rapamycin Administration on Mice
February 24, 2022
A team of researchers, including Steve Horvath, Leonid Peshkin, and Vadim Gladyshev, has published a preprint on bioRxiv showing the effects of early administration of rapamycin over the lifespans of mice. Rapamycin before and after weaning In this placebo-controlled experiment, the researchers selected the UMHET3 strain
NAD+ Levels Are Correlated with Physical Activity in Humans
February 22, 2022
In a study published in Nature Aging, a group of scientists has shown that NAD+ levels are correlated not only with age but with physical activity, with elder athletes rivaling normal young adults [1]. NAD: small, crucial, age-related Nicotinamide adenine dinucleotide (NAD) is as important as
A New Understanding of Telomere Attrition
February 21, 2022
In Nature Cell Biology, a team of researchers has presented a current review of telomeres and how they relate to aging, reflecting modern research into a decades-old topic. Telomeres and cellular senescence This paper touches upon senescent cells and the senescence-associated secretory phenotype (SASP) that they
Caloric Restriction Promotes Rejuvenation in Human Trials
February 18, 2022
In a new paper, Yale scientists present encouraging data from an unprecedented human study of caloric restriction, a powerful anti-aging intervention [1]. Eat less, live more Despite all the might of today’s science, simple lifestyle choices are still the clearest option for living longer and healthier.
A Fresh Examination of Epigenetic Clocks
February 17, 2022
In a preprint published in bioRxiv, Morgan Levine and colleagues have identified and grouped 5,717 epigenetic CpG sites into 12 different modules, conducting an in-depth examination into how epigenetic clocks work. What is a CpG site? Methylation cannot occur everywhere in the genome. The researchers explain
Muscular Oxidative Capacity Predicts Mobility Decline
February 16, 2022
Researchers publishing in Aging Cell have shown a relationship between mitochondrial dysfunction and mobility decline in older adults. A changing longitudinal study Since 1958, a team of researchers from the National Institute on Aging Intramural Research program has been conducting the Baltimore Longitudinal Study of Aging
New Treatment for Osteoarthritis Proposed
February 15, 2022
In a paper published in Nature Aging, a group of scientists outlines a previously unknown pathway that leads to osteoarthritis and describes a promising treatment [1]. Less than a killer, more than a nuisance There are plenty of deadly age-related diseases, and then there are others
New Partial Reprogramming Drastically Lowers Cellular Age
February 11, 2022
In a pre-print paper that has not yet been peer reviewed, a group of researchers presented a new highly efficient method of partial cellular reprogramming [1]. Young from old Our cells age, and old cells differ from young ones in multiple ways, including gene expression, telomere