Category: Biology of Aging
$70 Million Rejuvenome Initiative Launches
October 15, 2021
Recently, the Astera Institute has announced that it will be collaborating with the Buck Institute on its Rejuvenome project. The project is a focused research organization (FRO), a new model
Allele Associated With Alzheimer’s Improves Cognition
October 15, 2021
Scientists have demonstrated that “the Alzheimer’s allele” APOE e4 helps cognition earlier in life prior to the onset of the disease [1]. This might point at a possible reason for
A Path Towards Restoring Thymic Function
October 14, 2021
A study published in Cell Reports shows how the thymus is stimulated to repair itself when dying thymocytes are depleted, paving the way towards novel methods of thymic regeneration. Cycles
The Genetic Basis of Telomere Length
October 13, 2021
A new study in Nature Genetics has further illuminated the genetic regulation of telomere length and what implications it may have for various diseases and longevity. Telomeres and aging in
Escaping Stem Cells Exacerbate Age-Related Hair Loss
October 12, 2021
Scientists showed that hair loss happens partially as a result of stem cells escaping from hair follicles. They also shot a stunning time-lapse video of the process. The stem cell
The Link Between Brain Age and Blood Pressure
October 11, 2021
Researchers publishing in Frontiers in Aging Neuroscience have discovered that blood pressure is directly linked to brain aging. The BrainAGE clock For this analysis, the researchers chose BrainAGE, a well-known,
How a Protein Is Linked to Kidney Fibrosis With Age
October 7, 2021
Publishing in Aging, a team of researchers has reported that periostin, a protein that aids in development during the embryonic stage, is linked to kidney problems related to lipid metabolism
Matching an Epigenetic Clock to Physical Function
October 6, 2021
A new, three-year study published in The Journals of Gerontology: Series A examined the relationship between epigenetic clocks and physical performance in older women. Epigenetic clocks and biological age Epigenetic
Engineering Anti-Inflammatory Cells to Fight Arthritis
October 4, 2021
Publishing in Science Advances, a team of researchers has described how a scaffold containing genetically engineered induced pluripotent stem cells (iPSCs) can reduce symptoms in a mouse model of rheumatoid
Some Mutations Increase Cancer Risk by Making Cells Older
October 1, 2021
Cells from the breasts of women with mutations that increase their risk of breast cancer show signs of accelerated aging, according to new research [1]. Accelerated aging may make these
Study Suggests No Theoretical Limit on Human Lifespan
September 30, 2021
According to new research, it may be possible for humans to live 130 years or perhaps longer, but the chances of reaching that age are slim. New findings suggest that
The Effects of Caloric Restriction on Stem Cells
September 29, 2021
A review published in The Malaysian Journal of Medical Sciences has outlined what effects caloric restriction (CR) has on the development and differentiation of stem cells. Stem cells and their
Activity and Diet Shown to Slow Aging (Again)
September 28, 2021
Scientists have used DNA methylation markers to measure the anti-aging effects of healthy diet and physical activity, reaching interesting, if at times contradictory, results [1]. Move, eat healthy, check your
Our Brains’ Metabolism Changes as We Age
September 24, 2021
A study conducted in Sweden and published in Scientific Reports has outlined the relationship between aging and the metabolites present in cerebrospinal fluid (CSF), which cushions and supports the brain
Getting Proteins Right to Live Longer
September 23, 2021
Changing a single amino acid in a single protein boosts the fidelity of protein synthesis, and that is enough to increase lifespan in a variety of organisms, according to new
$70 Million Rejuvenome Initiative Launches
October 15, 2021
Recently, the Astera Institute has announced that it will be collaborating with the Buck Institute on its Rejuvenome project. The project is a focused research organization (FRO), a new model of organization that is laser-focused on a specific scientific challenge that cannot be solved by existing
Allele Associated With Alzheimer’s Improves Cognition
October 15, 2021
Scientists have demonstrated that “the Alzheimer’s allele” APOE e4 helps cognition earlier in life prior to the onset of the disease [1]. This might point at a possible reason for some aspects of aging. What makes us stronger kills us later The risk of developing Alzheimer’s,
A Path Towards Restoring Thymic Function
October 14, 2021
A study published in Cell Reports shows how the thymus is stimulated to repair itself when dying thymocytes are depleted, paving the way towards novel methods of thymic regeneration. Cycles of involution, not a steady decline The researchers cite previous research showing that the thymus, despite
The Genetic Basis of Telomere Length
October 13, 2021
A new study in Nature Genetics has further illuminated the genetic regulation of telomere length and what implications it may have for various diseases and longevity. Telomeres and aging in humans At one time the hottest topic in aging, telomeres are the protective caps at the
Escaping Stem Cells Exacerbate Age-Related Hair Loss
October 12, 2021
Scientists showed that hair loss happens partially as a result of stem cells escaping from hair follicles. They also shot a stunning time-lapse video of the process. The stem cell cycle Stem cells reside in “stem cell compartments” in various tissues. By differentiating into multiple types
The Link Between Brain Age and Blood Pressure
October 11, 2021
Researchers publishing in Frontiers in Aging Neuroscience have discovered that blood pressure is directly linked to brain aging. The BrainAGE clock For this analysis, the researchers chose BrainAGE, a well-known, machine learning-based biomarker that uses MRI imagery in order to determine age [1]. The researchers of
How a Protein Is Linked to Kidney Fibrosis With Age
October 7, 2021
Publishing in Aging, a team of researchers has reported that periostin, a protein that aids in development during the embryonic stage, is linked to kidney problems related to lipid metabolism in adults. Why does this protein exist? The researchers cite prior studies showing that periostin is
Matching an Epigenetic Clock to Physical Function
October 6, 2021
A new, three-year study published in The Journals of Gerontology: Series A examined the relationship between epigenetic clocks and physical performance in older women. Epigenetic clocks and biological age Epigenetic clocks attempt to estimate age based on measurable DNA modifications. However, not every individual ages at
Engineering Anti-Inflammatory Cells to Fight Arthritis
October 4, 2021
Publishing in Science Advances, a team of researchers has described how a scaffold containing genetically engineered induced pluripotent stem cells (iPSCs) can reduce symptoms in a mouse model of rheumatoid arthritis. The advantage over current drugs Rheumatoid arthritis (RA) is currently treated through drugs that often
Some Mutations Increase Cancer Risk by Making Cells Older
October 1, 2021
Cells from the breasts of women with mutations that increase their risk of breast cancer show signs of accelerated aging, according to new research [1]. Accelerated aging may make these cells worse at suppressing cancer development, offering both an explanation for the effect of these mutations
Study Suggests No Theoretical Limit on Human Lifespan
September 30, 2021
According to new research, it may be possible for humans to live 130 years or perhaps longer, but the chances of reaching that age are slim. New findings suggest that mortality risk plateaus past 110 For many years now, just how long a human being can
The Effects of Caloric Restriction on Stem Cells
September 29, 2021
A review published in The Malaysian Journal of Medical Sciences has outlined what effects caloric restriction (CR) has on the development and differentiation of stem cells. Stem cells and their exhaustion The reviewers began by discussing stem cell exhaustion, a hallmark of aging and a common
Activity and Diet Shown to Slow Aging (Again)
September 28, 2021
Scientists have used DNA methylation markers to measure the anti-aging effects of healthy diet and physical activity, reaching interesting, if at times contradictory, results [1]. Move, eat healthy, check your biological age Physical activity (PA) and healthy diet are two powerful interventions that have time and
Our Brains’ Metabolism Changes as We Age
September 24, 2021
A study conducted in Sweden and published in Scientific Reports has outlined the relationship between aging and the metabolites present in cerebrospinal fluid (CSF), which cushions and supports the brain and spine. A detailed, metabolic analysis The researchers extracted CSF from 41 people aged 20 to
Getting Proteins Right to Live Longer
September 23, 2021
Changing a single amino acid in a single protein boosts the fidelity of protein synthesis, and that is enough to increase lifespan in a variety of organisms, according to new research [1]. Proofreading proteins The loss of proteostasis is one of the hallmarks of aging. However,