Category: Biology of Aging
Parasitic Worm Infestation for Longevity
February 4, 2021
A review conducted by researchers at the Institute for Healthy Ageing at University College London in the UK has determined that infestation of the gut microbiome by helminths, a category
Neurons from Stem Cells Alleviate Parkinson’s Disease in Rats
February 2, 2021
In a new study, a group of researchers report on their success in priming stem cells to differentiate into dopaminergic neurons in rat brains. Loss of these neurons is a
Major Depressive Disorder Linked to Brain Aging
January 29, 2021
Recent data published in Neuropsychopharmacology has looked at changes in brain connectivity across lifespan and in patients with major depressive disorder. Biological and chronological age Your chronological age is simply
A New Resource for Developing Interventions to Treat Aging
January 28, 2021
Researchers at the Buck Institute for Research on Aging have published the results of a longitudinal and functional study of 700 aging mice [1]. The study took several years to
Rapamycin is Not a Caloric Restriction Mimetic
January 27, 2021
Although rapamycin reliably extends lifespan in a range of organisms, new research shows that it does not achieve this via the same pathways as caloric restriction [1]. Understanding how the
Cellvie Raises $5 Million for Mitochondrial Therapeutics
January 26, 2021
The mitochondria are an important target in aging, as their age-related dysfunction is thought to be a reason we age. These tiny power stations living in our cells do a
Age-related Decline in Cellular Stress Response Alleviated
January 26, 2021
Scientists have successfully reversed the decline in cellular stress response in drosophila flies [1]. Our cells rely on epigenetic regulation to do their various jobs: while a muscle cell has
Glucosamine May Be a Caloric Restriction Mimetic
January 25, 2021
Glucosamine is a polysaccharide that naturally occurs in cartilaginous joint tissues and is involved in protein and lipid synthesis. Glucosamine is also present in other tissues, such as skin, nails,
Senolytics Alleviate Age‐Related Cognitive Decline
January 22, 2021
A new study by a team of researchers, including Dr. Kirkland of Mayo Clinic, shows the effect of whole-body senolytic treatment on the health and function of the brain. This
Partial Reprogramming Rejuvenates Human Cells by 30 Years
January 21, 2021
Researchers from the Reik lab at the Babraham Institute have used the four Yamanaka reprogramming factors (OSKM) in order to epigenetically rejuvenate cells by 30 years, according to one epigenetic
Investigating the Link Between COVID-19 and Telomeres
January 20, 2021
New research published in Aging has analyzed the telomeres of patients hospitalized due to COVID-19. As the COVID-19 pandemic has spread rapidly across the globe, many researchers have pivoted their
AI Identifies Senescent Cells and Tests New Drugs
January 19, 2021
A group of scientists has created a neural network that identifies senescent cells by their morphology and can be used for senolytic drug screening [1]. Image recognition is a showcase
Alpha-Ketoglutarate Delays Age‐Related Fertility Decline
January 18, 2021
Alpha-ketoglutarate (AKG) is a popular dietary and sports supplement frequently used in the bodybuilding world, but interest in this molecule has more recently reached the aging research field for its
Looking Forward to a Productive 2021 in Aging Research
January 15, 2021
The world of rejuvenation biotechnology is a rapidly changing and ever developing place. As with any disruptive technology, the challenges are significant and include not only the technical aspects of
A Genetic Pathway for Preventing Hearing Loss
January 14, 2021
Activation of a genetic pathway controlled by the NRF2 gene reduces age-related hearing loss, according to a new study [1]. In the long run, drugs or treatments that target this
Parasitic Worm Infestation for Longevity
February 4, 2021
A review conducted by researchers at the Institute for Healthy Ageing at University College London in the UK has determined that infestation of the gut microbiome by helminths, a category of parasitic worms, may be a potential method of curbing the age-related inflammation known as inflammaging,
Neurons from Stem Cells Alleviate Parkinson’s Disease in Rats
February 2, 2021
In a new study, a group of researchers report on their success in priming stem cells to differentiate into dopaminergic neurons in rat brains. Loss of these neurons is a major cause of Parkinson’s disease [1]. Less neurons, more Parkinson’s Neuronal degeneration is the culprit behind
Major Depressive Disorder Linked to Brain Aging
January 29, 2021
Recent data published in Neuropsychopharmacology has looked at changes in brain connectivity across lifespan and in patients with major depressive disorder. Biological and chronological age Your chronological age is simply the amount of time that has passed since you were born, but your biological age represents
A New Resource for Developing Interventions to Treat Aging
January 28, 2021
Researchers at the Buck Institute for Research on Aging have published the results of a longitudinal and functional study of 700 aging mice [1]. The study took several years to complete, with five of the labs at the Buck collaborating. As part of this detailed study,
Rapamycin is Not a Caloric Restriction Mimetic
January 27, 2021
Although rapamycin reliably extends lifespan in a range of organisms, new research shows that it does not achieve this via the same pathways as caloric restriction [1]. Understanding how the two processes differ and interact could help researchers eventually piece together the longevity puzzle. Caloric or
Cellvie Raises $5 Million for Mitochondrial Therapeutics
January 26, 2021
The mitochondria are an important target in aging, as their age-related dysfunction is thought to be a reason we age. These tiny power stations living in our cells do a wonderful job producing energy and keeping us alive, but, as we age, they become increasingly dysfunctional
Age-related Decline in Cellular Stress Response Alleviated
January 26, 2021
Scientists have successfully reversed the decline in cellular stress response in drosophila flies [1]. Our cells rely on epigenetic regulation to do their various jobs: while a muscle cell has the same genome as a liver cell, the difference in gene expression is what sets them
Glucosamine May Be a Caloric Restriction Mimetic
January 25, 2021
Glucosamine is a polysaccharide that naturally occurs in cartilaginous joint tissues and is involved in protein and lipid synthesis. Glucosamine is also present in other tissues, such as skin, nails, bones, and ligaments. Synovial fluid contains glucosamine and occupies the space between joints, helping to reduce
Senolytics Alleviate Age‐Related Cognitive Decline
January 22, 2021
A new study by a team of researchers, including Dr. Kirkland of Mayo Clinic, shows the effect of whole-body senolytic treatment on the health and function of the brain. This follows up on previous Mayo Clinic research led by Dr. James Kirkland. That experiment treated mice
Partial Reprogramming Rejuvenates Human Cells by 30 Years
January 21, 2021
Researchers from the Reik lab at the Babraham Institute have used the four Yamanaka reprogramming factors (OSKM) in order to epigenetically rejuvenate cells by 30 years, according to one epigenetic clock. Reprogramming just beyond the threshold Previous experiments have shown that while exposing cells to the
Investigating the Link Between COVID-19 and Telomeres
January 20, 2021
New research published in Aging has analyzed the telomeres of patients hospitalized due to COVID-19. As the COVID-19 pandemic has spread rapidly across the globe, many researchers have pivoted their existing research to help characterize and fight the disease. Longevity researchers have been particularly interested in
AI Identifies Senescent Cells and Tests New Drugs
January 19, 2021
A group of scientists has created a neural network that identifies senescent cells by their morphology and can be used for senolytic drug screening [1]. Image recognition is a showcase triumph of artificial intelligence. While this problem was considered extremely hard to crack in previous decades,
Alpha-Ketoglutarate Delays Age‐Related Fertility Decline
January 18, 2021
Alpha-ketoglutarate (AKG) is a popular dietary and sports supplement frequently used in the bodybuilding world, but interest in this molecule has more recently reached the aging research field for its potential to slow down aging. AKG is a naturally occurring endogenous intermediary metabolite, which means that
Looking Forward to a Productive 2021 in Aging Research
January 15, 2021
The world of rejuvenation biotechnology is a rapidly changing and ever developing place. As with any disruptive technology, the challenges are significant and include not only the technical aspects of developing these technologies but also the hurdles of societal acceptance of the desirability of longer, healthier
A Genetic Pathway for Preventing Hearing Loss
January 14, 2021
Activation of a genetic pathway controlled by the NRF2 gene reduces age-related hearing loss, according to a new study [1]. In the long run, drugs or treatments that target this pathway could help us keep our hearing sharp as we get older. It’s getting harder and