Category: Biology of Aging
Resistance Training in Middle Age Doubles Muscle NAD+ Levels
May 13, 2020
A new study suggests that we can actively fight back against age-related decline with resistance training to restore our levels of NAD+, a critical molecule used by the mitochondria in
A Senolytic Prodrug For Multiple Cell Types
May 12, 2020
A group of scientists from China has successfully created an effective senolytic prodrug that targets the enzyme β-galactosidase [1]. This prodrug, called SSK1, has demonstrated impressive results across various cell
Blood Factors Reverse Epigenetic Age by Half in Rats
May 11, 2020
Researchers have demonstrated that epigenetic age can be halved in rats by using signals commonly found in the blood. Epigenetic changes One of the proposed reasons we age are the
The Challenge of Including Aging in the ICD
May 8, 2020
Few things in aging research are ever straightforward, and today’s topic is no exception, as two researchers enjoy some back and forth regarding whether and how the World Health Organization
Modulating Macrophages to Prevent Disc Degeneration
May 4, 2020
A paper published in Aging has shown that it is possible to treat spinal disc degeneration through altering the epigenetics of macrophages. Macrophages and inflammaging Macrophages are the clean-up crew
Senolytics Could Cause a Sea Change in How We Treat Aging
April 30, 2020
Today, we want to highlight a new review that takes a look at senescent cell removal therapies and their potential to treat and reverse age-related diseases by reversing one of
NMN Restores Brain Function In Old Mice
April 28, 2020
A group of researchers has demonstrated that treatment with NMN, a precursor of NAD+, restores neurovascular coupling (NVC) in aged mice [1]. Since NVC deficiency seems to be a major
Restoring Telomerase Activity in Telomere Biology Diseases
April 27, 2020
Researchers have demonstrated that it is possible to restore telomerase activity in stem cells affected by telomere biology diseases, which prevent them from producing telomerase and repairing their telomeres. Telomeres
Refining Senolytic Drugs to Be Less Toxic and More Effective
April 24, 2020
Researchers have developed a way to modify an existing cancer drug with toxic side effects into something that is less toxic to blood platelets and more effective at removing harmful
Fibroblasts Reprogrammed Into Photoreceptors Restore Vision
April 21, 2020
A group of researchers has succeeded in directly reprogramming fibroblast cells into photoreceptors and transplanting them into mice, which resulted in partial restoration of vision [1]. This achievement can potentially
Inflammaging Links Alzheimer’s and Changes to the Microbiome
April 20, 2020
A new review sheds light on the connection between chronic age-related inflammation, modern lifestyles, and the development of Alzheimer’s disease. Inflammaging is the link between the microbiome, aging, and Alzheimer’s
Metformin Reverses Myotonic Dystrophy Symptoms in Cells
April 16, 2020
A new study published in Aging shows that metformin, a drug that has been studied for its effects on longevity, restores mitochondrial function and repairs metabolic defects in cells from
The Top Risk Factor For COVID Is Your Age
April 13, 2020
There are many lessons to be learned from the current COVID-19 pandemic, particularly ones about how our society, healthcare system, and socioeconomic system can be better positioned and equipped to
Intermittent Fasting Has Multiple Health Benefits
April 8, 2020
Intermittent fasting is a common topic in the longevity community, and a new study suggests that there could be some benefits from adopting this lifestyle. Intermittent fasting has health benefits
Treating Asthma by Removing Senescent Cells
April 7, 2020
Could senolytic therapies designed to remove senescent cells, which accumulate with age, potentially be used to treat asthma? The researchers of a recent review certainly believe this could be the
Resistance Training in Middle Age Doubles Muscle NAD+ Levels
May 13, 2020
A new study suggests that we can actively fight back against age-related decline with resistance training to restore our levels of NAD+, a critical molecule used by the mitochondria in our cells to produce energy. NAD+ and mitochondria The mitochondria are the powerhouses of the cell,
A Senolytic Prodrug For Multiple Cell Types
May 12, 2020
A group of scientists from China has successfully created an effective senolytic prodrug that targets the enzyme β-galactosidase [1]. This prodrug, called SSK1, has demonstrated impressive results across various cell types and advantages over some existing senolytics. Cellular senescence is a phenomenon in which cells stop
Blood Factors Reverse Epigenetic Age by Half in Rats
May 11, 2020
Researchers have demonstrated that epigenetic age can be halved in rats by using signals commonly found in the blood. Epigenetic changes One of the proposed reasons we age are the changes to gene expression that our cells experience as we get older; these are commonly called
The Challenge of Including Aging in the ICD
May 8, 2020
Few things in aging research are ever straightforward, and today’s topic is no exception, as two researchers enjoy some back and forth regarding whether and how the World Health Organization (WHO) should recognize the aging processes as a disease. Proposing a new framework to facilitate development
Modulating Macrophages to Prevent Disc Degeneration
May 4, 2020
A paper published in Aging has shown that it is possible to treat spinal disc degeneration through altering the epigenetics of macrophages. Macrophages and inflammaging Macrophages are the clean-up crew of the immune system, engulfing and destroying harmful germs, but their polarization is a double-edged sword.
Senolytics Could Cause a Sea Change in How We Treat Aging
April 30, 2020
Today, we want to highlight a new review that takes a look at senescent cell removal therapies and their potential to treat and reverse age-related diseases by reversing one of the aging processes. The current approach of medicine to treating age-related disease is broken The current
NMN Restores Brain Function In Old Mice
April 28, 2020
A group of researchers has demonstrated that treatment with NMN, a precursor of NAD+, restores neurovascular coupling (NVC) in aged mice [1]. Since NVC deficiency seems to be a major factor in the age-related decline of cognitive and motor functions, this discovery presents exciting new possibilities
Restoring Telomerase Activity in Telomere Biology Diseases
April 27, 2020
Researchers have demonstrated that it is possible to restore telomerase activity in stem cells affected by telomere biology diseases, which prevent them from producing telomerase and repairing their telomeres. Telomeres and telomerase Each chromosome that stores our genetic information has a protective cap at each end
Refining Senolytic Drugs to Be Less Toxic and More Effective
April 24, 2020
Researchers have developed a way to modify an existing cancer drug with toxic side effects into something that is less toxic to blood platelets and more effective at removing harmful and inflammatory senescent cells, one of the reasons we age, from mice. What are senescent cells?
Fibroblasts Reprogrammed Into Photoreceptors Restore Vision
April 21, 2020
A group of researchers has succeeded in directly reprogramming fibroblast cells into photoreceptors and transplanting them into mice, which resulted in partial restoration of vision [1]. This achievement can potentially lead to the development of cheap and effective treatments for retinopathies such as age-related macular degeneration
Inflammaging Links Alzheimer’s and Changes to the Microbiome
April 20, 2020
A new review sheds light on the connection between chronic age-related inflammation, modern lifestyles, and the development of Alzheimer’s disease. Inflammaging is the link between the microbiome, aging, and Alzheimer’s disease Aging is accompanied by a chronic, smoldering background of inflammation known as inflammaging. This backdrop
Metformin Reverses Myotonic Dystrophy Symptoms in Cells
April 16, 2020
A new study published in Aging shows that metformin, a drug that has been studied for its effects on longevity, restores mitochondrial function and repairs metabolic defects in cells from people with myotonic dystrophy, a condition that shares many of the same characteristics as aging. A
The Top Risk Factor For COVID Is Your Age
April 13, 2020
There are many lessons to be learned from the current COVID-19 pandemic, particularly ones about how our society, healthcare system, and socioeconomic system can be better positioned and equipped to cope with future pandemics and other catastrophic events. One important takeaway, however, is already self-evident: age
Intermittent Fasting Has Multiple Health Benefits
April 8, 2020
Intermittent fasting is a common topic in the longevity community, and a new study suggests that there could be some benefits from adopting this lifestyle. Intermittent fasting has health benefits A new study published in the Journal of Proteomics builds on previous studies and suggests that
Treating Asthma by Removing Senescent Cells
April 7, 2020
Could senolytic therapies designed to remove senescent cells, which accumulate with age, potentially be used to treat asthma? The researchers of a recent review certainly believe this could be the case, and there is plenty of reason to think they could be right. Senescent cells and