Category: Biology of Aging
Glucose and the Gut Microbiome
August 9, 2018
Somewhat serendipitously, Salk Institute researchers discovered that depleting the microbiomes of mice causes the animals to have lower levels of blood glucose as well as improved insulin sensitivity [1]. Abstract
Hair Loss Related to Western Diet Reversed in Mice
August 1, 2018
Scientists at the Johns Hopkins University reversed hair whitening and loss associated with a high-fat, high-cholesterol diet by using an experimental compound in a mouse model [1]. The compound The
Too healthy for your own good?
July 3, 2018
Recently, Reason of Fight Aging! pointed out psychological research revealing a certain conservatism in terms of what people consider to be the “ideal” levels of happiness, intelligence, longevity, and even
Other Solutions to Senescent Cells than Senolytics
July 2, 2018
Senolytics have been in the news a great deal ever since van Deursen and his team conducted a landmark 2011 study showing that removing senescent cells could delay age-related ill
The First Rejuvenation Therapy Reaches Human Trials
June 29, 2018
Today we are pleased to announce that UNITY Biotechnology is going into human clinical trials with the first true rejuvenation therapy that directly targets one of the processes of aging:
Antioxidant inhibitor might be a regulator of aging
June 25, 2018
According to scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, or DKFZ), the enzyme TXNIP, which inhibits the enzyme TRX-1, might be a regulator of aging and might be
Using Nanoscale Robots to Fight Aging and Disease
June 21, 2018
At least in the developed world, cancer, heart diseases, and neurodegenerative diseases are among the greatest causes of mortality. One emerging and very promising way to prevent or cure these
Aggregated α-synuclein leads to cell death in Parkinson’s
June 20, 2018
An open-access paper published in Nature Communications sheds light on how an accumulation of α-synuclein protein in brain cells contributes to causing Parkinson’s disease. In particular, the researchers discovered how
Senolytics for Age-Related Muscle Loss and Frailty
June 16, 2018
Today, we want to draw your attention to an open-access review that focuses on the role of senescent cells in sarcopenia, the age-related loss of muscle mass and strength that
NAD+ Precursor Has Therapeutic Potential Against Parkinsons Disease
June 7, 2018
Today, we will be taking a look at a new study showing that an NAD+ precursor was able to improve mitochondrial function in cells and flies with a model of
Using a Natural Antibody to Combat Atherosclerosis
June 7, 2018
Researchers at the University of California San Diego School of Medicine have shown that they can block inflammation in mice, thereby protecting them from liver disease and hardening of the
Mitochondrial dysfunction in aged brain cells
June 5, 2018
Thanks to a new technique, researchers from the Salk Institute’s Gage laboratory have shown that impaired energy production might be a reason why human brains are susceptible to age-related diseases
A New Way to Control High Blood Pressure
June 4, 2018
Researchers at the National University of Singapore (NUS) have potentially found a new way to combat hypertension by discovering how blood pressure is controlled. What is hypertension? High blood pressure,
Increased Autophagy Promotes Healthy Longevity in Mice
June 1, 2018
A new study suggests that autophagy, the recycling, and disposal system that cells use to remove unwanted garbage, can extend the healthy lifespan of mammals. The study, led by Drs.
A Health and Longevity Strategy
May 31, 2018
Who wants to lose weight, feel great, and live a long and healthy life, and what does it take to achieve these goals? Diet and exercise are equally important in
Glucose and the Gut Microbiome
August 9, 2018
Somewhat serendipitously, Salk Institute researchers discovered that depleting the microbiomes of mice causes the animals to have lower levels of blood glucose as well as improved insulin sensitivity [1]. Abstract Antibiotic-induced microbiome depletion (AIMD) has been used frequently to study the role of the gut microbiome
Hair Loss Related to Western Diet Reversed in Mice
August 1, 2018
Scientists at the Johns Hopkins University reversed hair whitening and loss associated with a high-fat, high-cholesterol diet by using an experimental compound in a mouse model [1]. The compound The experimental compound used by the researchers, called D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D–PDMP) acts by blocking the production of glucosphingolipids
Too healthy for your own good?
July 3, 2018
Recently, Reason of Fight Aging! pointed out psychological research revealing a certain conservatism in terms of what people consider to be the “ideal” levels of happiness, intelligence, longevity, and even health. It probably doesn’t come as a surprise that significant numbers of people in the studies
Other Solutions to Senescent Cells than Senolytics
July 2, 2018
Senolytics have been in the news a great deal ever since van Deursen and his team conducted a landmark 2011 study showing that removing senescent cells could delay age-related ill health in mice [1]. Since then, interest in what was once a niche topic has continued
The First Rejuvenation Therapy Reaches Human Trials
June 29, 2018
Today we are pleased to announce that UNITY Biotechnology is going into human clinical trials with the first true rejuvenation therapy that directly targets one of the processes of aging: senescent cells. The quiet revolution In our collective imagination, revolutions start with a bang; however, more
Antioxidant inhibitor might be a regulator of aging
June 25, 2018
According to scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, or DKFZ), the enzyme TXNIP, which inhibits the enzyme TRX-1, might be a regulator of aging and might be a viable candidate for future interventions against age-related diseases [1]. Study summary The “free radical theory
Using Nanoscale Robots to Fight Aging and Disease
June 21, 2018
At least in the developed world, cancer, heart diseases, and neurodegenerative diseases are among the greatest causes of mortality. One emerging and very promising way to prevent or cure these diseases is through bio-nanotechnology. Nanotechnology is the design, synthesis and application of materials or devices that
Aggregated α-synuclein leads to cell death in Parkinson’s
June 20, 2018
An open-access paper published in Nature Communications sheds light on how an accumulation of α-synuclein protein in brain cells contributes to causing Parkinson’s disease. In particular, the researchers discovered how clumps of the protein damage important proteins on mitochondrial surfaces, leading to impaired energy production, swelling
Senolytics for Age-Related Muscle Loss and Frailty
June 16, 2018
Today, we want to draw your attention to an open-access review that focuses on the role of senescent cells in sarcopenia, the age-related loss of muscle mass and strength that leads to frailty. Aging is the prime risk factor for the broad-based development of diseases. Frailty
NAD+ Precursor Has Therapeutic Potential Against Parkinsons Disease
June 7, 2018
Today, we will be taking a look at a new study showing that an NAD+ precursor was able to improve mitochondrial function in cells and flies with a model of Parkinson’s disease. While mitochondrial dysfunction is emerging as key in Parkinson’s disease (PD), a central question
Using a Natural Antibody to Combat Atherosclerosis
June 7, 2018
Researchers at the University of California San Diego School of Medicine have shown that they can block inflammation in mice, thereby protecting them from liver disease and hardening of the arteries while increasing their healthy lifespan. The study, published in the journal Nature, shows that inflammation
Mitochondrial dysfunction in aged brain cells
June 5, 2018
Thanks to a new technique, researchers from the Salk Institute’s Gage laboratory have shown that impaired energy production might be a reason why human brains are susceptible to age-related diseases in the first place [1]. In particular, Salk scientists observed that induced neurons (iNs) obtained from
A New Way to Control High Blood Pressure
June 4, 2018
Researchers at the National University of Singapore (NUS) have potentially found a new way to combat hypertension by discovering how blood pressure is controlled. What is hypertension? High blood pressure, or hypertension, rarely has noticeable symptoms. However, if it is left untreated, your risk of serious
Increased Autophagy Promotes Healthy Longevity in Mice
June 1, 2018
A new study suggests that autophagy, the recycling, and disposal system that cells use to remove unwanted garbage, can extend the healthy lifespan of mammals. The study, led by Drs. Salwa Sebti and Alvaro Fernández from the Center for Autophagy Research, has discovered that mice with
A Health and Longevity Strategy
May 31, 2018
Who wants to lose weight, feel great, and live a long and healthy life, and what does it take to achieve these goals? Diet and exercise are equally important in long-term health, but let’s look at what recent science is telling us about the healthiest diets.