Category: Research
How Donated Stem Cells Become Functional Cells
June 8, 2023
Scientists have verified the effectiveness of stem cell transplants, researched a core reason behind it, and published their findings in Aging Cell. The niche controls what stem cells do Back
Castration Influences Growth and Median Lifespan in Mice
June 7, 2023
Research published in Aging Cell has discovered that castrated male mice show similarities to females in growth and lifespan [1]. It is widely known that women outlive men on average,
Michael Lustgarten Fights Back Against Microbes
June 6, 2023
Dr. Michael Lustgarten delivers a clear and enlightening exploration of the intricate relationship between microbial burden and aging in Microbial Burden: A Major Cause of Aging and Age-Related Disease and
Giving Old Stem Cells Lasting Youthful Powers
June 5, 2023
Researchers publishing in Cell Proliferation have described factors that appear to give old muscle stem cells the ability to effectively proliferate and differentiate for a very long time. When renewal
Benefits of Dasatinib and Quercetin Treatment in Monkeys
June 2, 2023
In one of the first studies of its kind, the popular senolytic combination, administered systematically for six months, produced several health benefits in these animals. Some effects were augmented by
Linking Bile Duct Blockage and Cellular Senescence
June 1, 2023
Research published in Aging has shed new light on the relationship between certain liver diseases and cellular senescence. Clogged bile ducts and senescence There are multiple documented causes of cellular
Vitalik Buterin Exclusive Interview: Longevity, AI and More
May 30, 2023
Vitalik Buterin holding Zuzu, the puppy rescued by people of Zuzalu. Photo: Michelle Lai Don’t try finding Zuzalu on a map; it doesn’t exist anymore. It was a “pop-up city”
Centenarians Have Slightly Different Gut Ecologies
May 29, 2023
Researchers publishing in Nature Microbiology have determined that the viruses populating the intestines of centenarians are slightly different from those of the merely old. Viruses for bacteria, not people We
Hypoxia Extends Median Lifespan in Fast-Aging Mice by 50%
May 26, 2023
Scientists have found that continuous oxygen restriction drastically extends the lifespan of progeroid mice, but the effect’s mechanism remains a mystery [1]. Can less oxygen be better? Hypoxia is a
Discovering Why Adrenal Cancer Is More Dangerous for Women
May 25, 2023
A paper published today in Nature Aging has explained a relationship between cellular senescence, cancer of the adrenal glands, and sex differences. A closer look at age-related cancer Over 90%
Using AI to Discover New Rapamycin-Like Molecules
May 24, 2023
In a recent paper published in International Journal of Medical Sciences, researchers have described how they used artificial intelligence and machine learning tools to find mTOR-inhibiting molecules [1]. mTOR is
How Your Funding Has Helped Mitochondrial Research
May 24, 2023
Financed by lifespan.io’s crowdfunding efforts, SENS Research Foundation has engaged in fruitful research into ways of dealing with mitochondrial dysfunction, the gradual loss of function of our cells’ power plants.
A New Tool for Editing Mitochondrial DNA
May 22, 2023
Researchers publishing in Nature Biotechnology have developed a novel method of editing mitochondrial DNA, which cannot be accomplished with nuclear DNA tools. Where CRISPR doesn’t work While CRISPR is the
Rare Gene Variant Appears to Protect Against Alzheimer’s
May 19, 2023
Scientists studying people with autosomal dominant Alzheimer’s disease have found a genetic variant that is associated with decades of stalled onset [1]. The predictable Alzheimer’s Scientists still do not know
A Senolytic Drug May Already Be in the Clinic
May 18, 2023
Researchers publishing in Aging have investigated zoledronic acid, a drug already used to protect bones and fight osteoporosis, for its activity against cellular senescence. An approved drug with established effects
How Donated Stem Cells Become Functional Cells
June 8, 2023
Scientists have verified the effectiveness of stem cell transplants, researched a core reason behind it, and published their findings in Aging Cell. The niche controls what stem cells do Back in 1978, Raymond Schofield proposed that hematopoietic stem cells (HSCs), which make blood cells, are governed
Castration Influences Growth and Median Lifespan in Mice
June 7, 2023
Research published in Aging Cell has discovered that castrated male mice show similarities to females in growth and lifespan [1]. It is widely known that women outlive men on average, but the biological reasons are still not fully understood. As it is challenging to experimentally test
Michael Lustgarten Fights Back Against Microbes
June 6, 2023
Dr. Michael Lustgarten delivers a clear and enlightening exploration of the intricate relationship between microbial burden and aging in Microbial Burden: A Major Cause of Aging and Age-Related Disease and What We Can Do to Fight Back! Through meticulous research and compelling analysis, the author sheds
Giving Old Stem Cells Lasting Youthful Powers
June 5, 2023
Researchers publishing in Cell Proliferation have described factors that appear to give old muscle stem cells the ability to effectively proliferate and differentiate for a very long time. When renewal runs out Many of the problems that elderly people face in daily life, such as frailty,
Benefits of Dasatinib and Quercetin Treatment in Monkeys
June 2, 2023
In one of the first studies of its kind, the popular senolytic combination, administered systematically for six months, produced several health benefits in these animals. Some effects were augmented by caloric restriction [1]. Coup de grâce for cells The combination of the drug dasatinib and the
Linking Bile Duct Blockage and Cellular Senescence
June 1, 2023
Research published in Aging has shed new light on the relationship between certain liver diseases and cellular senescence. Clogged bile ducts and senescence There are multiple documented causes of cellular senescence, such as radiation and chemical insults, which are frequently performed in experiments to test senescence
Vitalik Buterin Exclusive Interview: Longevity, AI and More
May 30, 2023
Vitalik Buterin holding Zuzu, the puppy rescued by people of Zuzalu. Photo: Michelle Lai Don’t try finding Zuzalu on a map; it doesn’t exist anymore. It was a “pop-up city” conceived by the tech entrepreneur Vitalik Buterin, creator of Ethereum, and a group of like-minded people
Centenarians Have Slightly Different Gut Ecologies
May 29, 2023
Researchers publishing in Nature Microbiology have determined that the viruses populating the intestines of centenarians are slightly different from those of the merely old. Viruses for bacteria, not people We have written previously about a study showing that centenarians have youthful bacterial gut compositions (enterotypes) similar
Hypoxia Extends Median Lifespan in Fast-Aging Mice by 50%
May 26, 2023
Scientists have found that continuous oxygen restriction drastically extends the lifespan of progeroid mice, but the effect’s mechanism remains a mystery [1]. Can less oxygen be better? Hypoxia is a condition in which an organism or an organ in the body does not receive enough oxygen.
Discovering Why Adrenal Cancer Is More Dangerous for Women
May 25, 2023
A paper published today in Nature Aging has explained a relationship between cellular senescence, cancer of the adrenal glands, and sex differences. A closer look at age-related cancer Over 90% of cancer diagnoses are made in people over a half century old [1]. This is not
Using AI to Discover New Rapamycin-Like Molecules
May 24, 2023
In a recent paper published in International Journal of Medical Sciences, researchers have described how they used artificial intelligence and machine learning tools to find mTOR-inhibiting molecules [1]. mTOR is a common target for lifespan extension interventions The mechanistic target of rapamycin (mTOR) is a well-known
How Your Funding Has Helped Mitochondrial Research
May 24, 2023
Financed by lifespan.io’s crowdfunding efforts, SENS Research Foundation has engaged in fruitful research into ways of dealing with mitochondrial dysfunction, the gradual loss of function of our cells’ power plants. Here, the organization reports its successes in handling this aspect of aging. The cellular machinery and
A New Tool for Editing Mitochondrial DNA
May 22, 2023
Researchers publishing in Nature Biotechnology have developed a novel method of editing mitochondrial DNA, which cannot be accomplished with nuclear DNA tools. Where CRISPR doesn’t work While CRISPR is the established, go-to method for genetic modification in the nucleus, it doesn’t work in the mitochondria. CRISPR
Rare Gene Variant Appears to Protect Against Alzheimer’s
May 19, 2023
Scientists studying people with autosomal dominant Alzheimer’s disease have found a genetic variant that is associated with decades of stalled onset [1]. The predictable Alzheimer’s Scientists still do not know what causes most cases of Alzheimer’s, although certain genetic variants (most notably APOE4) have been shown
A Senolytic Drug May Already Be in the Clinic
May 18, 2023
Researchers publishing in Aging have investigated zoledronic acid, a drug already used to protect bones and fight osteoporosis, for its activity against cellular senescence. An approved drug with established effects Zoledronate has already been approved by the FDA for clinical use, as it has been prescribed