Category: Research
Retroviruses Contribute to the Spread of Cellular Senescence
February 7, 2023
Scientists have found that the remnants of the ancient retrovirus family HERVK, which reside in our genome, are transcribed more frequently in aged cells. This is caused by cellular senescence
Diagnosing Alzheimer’s in the Near Infrared
February 6, 2023
In Nature Biomedical Engineering, a team of researchers has published an innovative method of making tau tangles and amyloid beta visible in the near infrared, allowing doctors and researchers to
Is Increasing Human Lifespan Unnatural?
February 5, 2023
Whenever the topic of any possible increased healthy longevity through science is discussed, a common objection to developing the technology is that it is unnatural. This argument usually arises during
Senolytic Improves Metabolism in Mice
February 3, 2023
Scientists have shown that a popular senolytic combination of dasatinib and quercetin improves glucose tolerance and fasting blood glucose levels in aged mice [1]. The question of metabolism Cellular senescence
Photosensitive Drug Clears Senescent Cells
February 2, 2023
Research published in Nature Aging has shown that a photosensitive senolytic drug can be used to selectively remove senescent cells, slowing functional organ aging in mice. A problem of delivery
Ultrasound Rejuvenates Senescent Cells Through Autophagy
February 1, 2023
In a preprint paper, the researchers have shown that low-frequency ultrasound treatment decreases senescence and improves the physical performance of aged mice [1]. Mechanical approach Cellular senescence, the inability of
VitaDAO Closes $4.1 Million Fundraising Round
January 31, 2023
VitaDAO, a decentralized organization funding early-stage longevity research and biotech start-ups, has announced the successful closing of a $4.1 million funding round dedicated to financing future longevity projects and furthering
Longevity-Associated Allele Protects Heart Function in Mice
January 31, 2023
Scientists have shown that a longevity-associated variant of the BPIFB4 gene protects cardiovascular health, including when introduced by viral vectors [1]. All you need is LAV Among age-related pathologies, cardiovascular
Gene Therapy for Heart Regeneration in Living Animals
January 30, 2023
Research published in Cell Stem Cell has described how previously unmodified animals have been given regenerative abilities akin to those of zebrafish, restoring their heart muscle after injury. A TREE
New Way to Help Aging Cells Produce Collagen
January 27, 2023
Scientists have demonstrated that extracellular vesicles loaded with mRNA coding for collagen production can be easily produced and delivered into aging fibroblasts in vitro and in vivo, boosting collagen levels
Brain Aging on a Small, Physical Level
January 26, 2023
A new publication in Nature Aging has explained a great deal about aging of the neurovascular system, showing where and how the brain’s blood supply changes with aging in a
Caloric Restriction Does Not Extend Lifespan in Every Model
January 25, 2023
In a preprint paper, researchers have evaluated the effect of caloric restriction on two long-lived planarian species in various environments that mimic the stochasticity of the real world [1]. Does
Partial Reprogramming Extends Lifespan in Old Mice
January 25, 2023
The journal club returns on Tuesday 31st January at 12:00 Eastern on our Facebook page with host Dr. Oliver Medvedik. We are looking at a preprint this time where partial
Allogeneic CAR-T Cells Complete Phase 1 Trial
January 23, 2023
The results of a Phase 1 clinical trial of allogeneic CAR T cell therapy against multiple myeloma have been published today in Nature Medicine, and they appear to be promising.
Senescent Cells Leave Fragments Attached to Other Cells
January 20, 2023
In a preprint paper, scientists have reported that senescent cells transiently adhere to neighboring cells, and, upon departure, leave in place large membrane-enclosed fragments of themselves [1]. Mysterious fragments Cellular
Retroviruses Contribute to the Spread of Cellular Senescence
February 7, 2023
Scientists have found that the remnants of the ancient retrovirus family HERVK, which reside in our genome, are transcribed more frequently in aged cells. This is caused by cellular senescence and accelerates it, including in the neighboring cells, when those are infected by retroviral particles [1].
Diagnosing Alzheimer’s in the Near Infrared
February 6, 2023
In Nature Biomedical Engineering, a team of researchers has published an innovative method of making tau tangles and amyloid beta visible in the near infrared, allowing doctors and researchers to see through bone with relatively simple equipment. Current methods are difficult There are three main approaches
Is Increasing Human Lifespan Unnatural?
February 5, 2023
Whenever the topic of any possible increased healthy longevity through science is discussed, a common objection to developing the technology is that it is unnatural. This argument usually arises during discussions of therapies that directly address the various processes of aging, and it is important to understand their basis
Senolytic Improves Metabolism in Mice
February 3, 2023
Scientists have shown that a popular senolytic combination of dasatinib and quercetin improves glucose tolerance and fasting blood glucose levels in aged mice [1]. The question of metabolism Cellular senescence is one of the hallmarks of aging, and senolytics, drugs that clear away senescent cells, have
Photosensitive Drug Clears Senescent Cells
February 2, 2023
Research published in Nature Aging has shown that a photosensitive senolytic drug can be used to selectively remove senescent cells, slowing functional organ aging in mice. A problem of delivery The researchers name three problems with senolytic drugs: specificity to senescent cells (accuracy), controllability of administration
Ultrasound Rejuvenates Senescent Cells Through Autophagy
February 1, 2023
In a preprint paper, the researchers have shown that low-frequency ultrasound treatment decreases senescence and improves the physical performance of aged mice [1]. Mechanical approach Cellular senescence, the inability of aged cells to divide while still being metabolically active, is one of the hallmarks of aging.
VitaDAO Closes $4.1 Million Fundraising Round
January 31, 2023
VitaDAO, a decentralized organization funding early-stage longevity research and biotech start-ups, has announced the successful closing of a $4.1 million funding round dedicated to financing future longevity projects and furthering its commercialization and licensing strategy for IP-NFT assets. Key contributors to the fundraising round include Shine
Longevity-Associated Allele Protects Heart Function in Mice
January 31, 2023
Scientists have shown that a longevity-associated variant of the BPIFB4 gene protects cardiovascular health, including when introduced by viral vectors [1]. All you need is LAV Among age-related pathologies, cardiovascular disease is the most prolific killer, claiming about 700,000 victims every year in the US alone
Gene Therapy for Heart Regeneration in Living Animals
January 30, 2023
Research published in Cell Stem Cell has described how previously unmodified animals have been given regenerative abilities akin to those of zebrafish, restoring their heart muscle after injury. A TREE of life This study is introduced with a discussion of gene therapy as a field, noting
New Way to Help Aging Cells Produce Collagen
January 27, 2023
Scientists have demonstrated that extracellular vesicles loaded with mRNA coding for collagen production can be easily produced and delivered into aging fibroblasts in vitro and in vivo, boosting collagen levels and eliminating signs of skin aging in mice [1]. Superior delivery method Finding a good way
Brain Aging on a Small, Physical Level
January 26, 2023
A new publication in Nature Aging has explained a great deal about aging of the neurovascular system, showing where and how the brain’s blood supply changes with aging in a mouse model. A branching network of blood vessels In the neurovascular system, arteries lead to arterioles,
Caloric Restriction Does Not Extend Lifespan in Every Model
January 25, 2023
In a preprint paper, researchers have evaluated the effect of caloric restriction on two long-lived planarian species in various environments that mimic the stochasticity of the real world [1]. Does the theory hold? According to a theory that is largely based on plentiful data from model
Partial Reprogramming Extends Lifespan in Old Mice
January 25, 2023
The journal club returns on Tuesday 31st January at 12:00 Eastern on our Facebook page with host Dr. Oliver Medvedik. We are looking at a preprint this time where partial reprogramming factors were used to reverse some aspects of aging in old mice. The paper is
Allogeneic CAR-T Cells Complete Phase 1 Trial
January 23, 2023
The results of a Phase 1 clinical trial of allogeneic CAR T cell therapy against multiple myeloma have been published today in Nature Medicine, and they appear to be promising. B cells, engineered T cells, and lymphodepletion Multiple myeloma is a cancer of the plasma B
Senescent Cells Leave Fragments Attached to Other Cells
January 20, 2023
In a preprint paper, scientists have reported that senescent cells transiently adhere to neighboring cells, and, upon departure, leave in place large membrane-enclosed fragments of themselves [1]. Mysterious fragments Cellular senescence is central to aging, but there are still a lot of unknowns around this complex