Category: Research
NMN Boosts Effectiveness of Immunotherapy in Mice
May 10, 2022
In a pre-print paper, scientists have shown that treatment with NMN increases the survival and anti-cancer efficacy of CAR-T cells [1]. The problem with immunotherapy T cells are a central
The Gut Microbiome Affects the Brain, Eyes, and Gut in Mice
May 9, 2022
Publishing in Microbiome, a team of researchers has ascertained multiple physical effects of aging gut flora in mice. Antibiotics and fecal transfers The researchers used three groups of mice: young
Cannabidiol Increases Lifespan and Healthspan in Worms
May 6, 2022
Scientists have shown that an active ingredient of cannabis significantly upregulates autophagy, extending both lifespan and healthspan in C. elegans nematode worms. Two of the most well-known components of marijuana
Why The Skin of Naked Mole Rats Ages Slowly
May 5, 2022
A study published in Aging has shown that the skin of the naked mole rat retains nearly all of its physical and biochemical properties as these animals chronologically age, providing
Longevity in Centenarians Linked to Lower Ribosomal Activity
May 3, 2022
Scientists have discovered a possible mechanism that protects extremely long-lived people from aging [1]. Protected persons A few days ago, news came of the death of the oldest person in
Senescent Cells Slow Bone Healing
May 2, 2022
A study published in the Journal of Clinical Investigation has reported that senescent cells are largely responsible for slow bone healing in aged animals and that senolytics, which remove these
Cellular Reprogramming Boosts Liver Regeneration in Mice
April 29, 2022
Scientists have shown that partial cellular reprogramming can significantly increase the already impressive regenerative capacity of the liver and protect this crucial organ from a potentially lethal injury [1]. Why
Synergy Between Stem Cell Rejuvenation and Senolytics
April 28, 2022
In a preprint published in bioRxiv, a team of Singaporean researchers, including Jan Gruber, has found that a combination of stem cell rejuvenation and senescent cell removal is synergistically more
An Epigenetic Clock for Brain Age and Alzheimer’s Disease
April 27, 2022
The risk of Alzheimer’s disease goes up with age, and the number of people living with Alzheimer’s is growing. While it is known to be associated with the loss of
Early Life Rapamycin Treatment Effective in Flies and Mice
April 26, 2022
In a preprint paper, scientists have shown that treating drosophila flies and mice with rapamycin for a relatively brief period in early life mostly recapitulates the effects of a lifelong
A Genetic Analysis of Chronic Inflammation
April 25, 2022
Nature Communications has recently published a paper discussing the genetic sources of C-reactive protein, a well-known biomarker of chronic inflammation. An extremely broad study with a wide variety of genes
Plastic Nanoparticles in Cellular Senescence and Dysfunction
April 22, 2022
Scientists have found that exposure to plastic nanoparticles drives cellular senescence and dysfunction in endothelial cells taken from a pig’s coronary artery [1]. A widespread pollutant Plastic has changed the
Combining Caloric Restriction and Rapamycin
April 21, 2022
A new study published in Nature Communications has found that rapamycin, which is often considered to be a calorie restriction mimetic, has different and additive effects to caloric restriction in
Toll-like Receptor Deletion Improves Memory in Aged Mice
April 19, 2022
In a new study, genetic deletion of the TLR4 receptor ameliorated aspects of age-related cognitive decline in naturally aging mice, probably due to decreased inflammation [1]. Taking a toll as
Small Molecule Protects Against Oxidative Aging in Egg Cells
April 18, 2022
A group of researchers has documented in Aging that Epitalon, a synthetic peptide made of four amino acids, slows the aging of egg cells (oocytes) after ovulation. Aging makes fertilization
NMN Boosts Effectiveness of Immunotherapy in Mice
May 10, 2022
In a pre-print paper, scientists have shown that treatment with NMN increases the survival and anti-cancer efficacy of CAR-T cells [1]. The problem with immunotherapy T cells are a central element of the adaptive immune system, and some of them can be cytotoxic: they have the
The Gut Microbiome Affects the Brain, Eyes, and Gut in Mice
May 9, 2022
Publishing in Microbiome, a team of researchers has ascertained multiple physical effects of aging gut flora in mice. Antibiotics and fecal transfers The researchers used three groups of mice: young (3 months), old (18 months), and aged (24 months). Young and old groups were divided into
Cannabidiol Increases Lifespan and Healthspan in Worms
May 6, 2022
Scientists have shown that an active ingredient of cannabis significantly upregulates autophagy, extending both lifespan and healthspan in C. elegans nematode worms. Two of the most well-known components of marijuana are tetrahydrocannabinol (THC) and cannabidiol (CBD). They have the same atomic composition, but differ in structure
Why The Skin of Naked Mole Rats Ages Slowly
May 5, 2022
A study published in Aging has shown that the skin of the naked mole rat retains nearly all of its physical and biochemical properties as these animals chronologically age, providing new insight into how and why these animals live so long. Wrinkly, but not like humans
Longevity in Centenarians Linked to Lower Ribosomal Activity
May 3, 2022
Scientists have discovered a possible mechanism that protects extremely long-lived people from aging [1]. Protected persons A few days ago, news came of the death of the oldest person in the world (and the oldest ever to have her age indisputably confirmed), 119-year-old Kane Tanaka from
Senescent Cells Slow Bone Healing
May 2, 2022
A study published in the Journal of Clinical Investigation has reported that senescent cells are largely responsible for slow bone healing in aged animals and that senolytics, which remove these harmful cells, can speed bone regeneration. A brief outline of bone healing The researchers begin their
Cellular Reprogramming Boosts Liver Regeneration in Mice
April 29, 2022
Scientists have shown that partial cellular reprogramming can significantly increase the already impressive regenerative capacity of the liver and protect this crucial organ from a potentially lethal injury [1]. Why can’t we regrow limbs? Cellular reprogramming induces de-differentiation of somatic cells back into pluripotent stem cells:
Synergy Between Stem Cell Rejuvenation and Senolytics
April 28, 2022
In a preprint published in bioRxiv, a team of Singaporean researchers, including Jan Gruber, has found that a combination of stem cell rejuvenation and senescent cell removal is synergistically more effective than either alone. Different but related aspects of aging The researchers begin this paper by
An Epigenetic Clock for Brain Age and Alzheimer’s Disease
April 27, 2022
The risk of Alzheimer’s disease goes up with age, and the number of people living with Alzheimer’s is growing. While it is known to be associated with the loss of proteostasis, it has also been found to be associated with epigenetic alterations. An advanced online preprint
Early Life Rapamycin Treatment Effective in Flies and Mice
April 26, 2022
In a preprint paper, scientists have shown that treating drosophila flies and mice with rapamycin for a relatively brief period in early life mostly recapitulates the effects of a lifelong treatment, including lifespan extension in flies [1]. Rapamycin is considered one of the most promising geroprotective
A Genetic Analysis of Chronic Inflammation
April 25, 2022
Nature Communications has recently published a paper discussing the genetic sources of C-reactive protein, a well-known biomarker of chronic inflammation. An extremely broad study with a wide variety of genes Pulling genomic data from 427,367 participants in the UK Biobank and 148,164 people from the Cohorts
Plastic Nanoparticles in Cellular Senescence and Dysfunction
April 22, 2022
Scientists have found that exposure to plastic nanoparticles drives cellular senescence and dysfunction in endothelial cells taken from a pig’s coronary artery [1]. A widespread pollutant Plastic has changed the face of civilization, but the convenience of plastic comes at a price – mostly in terms
Combining Caloric Restriction and Rapamycin
April 21, 2022
A new study published in Nature Communications has found that rapamycin, which is often considered to be a calorie restriction mimetic, has different and additive effects to caloric restriction in muscle tissue. The role of mTORC1 Mammalian target of rapamycin complex 1 (mTORC1) is a well-known
Toll-like Receptor Deletion Improves Memory in Aged Mice
April 19, 2022
In a new study, genetic deletion of the TLR4 receptor ameliorated aspects of age-related cognitive decline in naturally aging mice, probably due to decreased inflammation [1]. Taking a toll as we age Toll-like receptor 4 (TLR4) is a member of an ancient, highly evolutionary conserved family
Small Molecule Protects Against Oxidative Aging in Egg Cells
April 18, 2022
A group of researchers has documented in Aging that Epitalon, a synthetic peptide made of four amino acids, slows the aging of egg cells (oocytes) after ovulation. Aging makes fertilization difficult Oocyte aging is well-known to lead to fertilization deficiencies and a host of other problems