Category: Research
The Genetic Basis of Telomere Length
October 13, 2021
A new study in Nature Genetics has further illuminated the genetic regulation of telomere length and what implications it may have for various diseases and longevity. Telomeres and aging in
Escaping Stem Cells Exacerbate Age-Related Hair Loss
October 12, 2021
Scientists showed that hair loss happens partially as a result of stem cells escaping from hair follicles. They also shot a stunning time-lapse video of the process. The stem cell
The Link Between Brain Age and Blood Pressure
October 11, 2021
Researchers publishing in Frontiers in Aging Neuroscience have discovered that blood pressure is directly linked to brain aging. The BrainAGE clock For this analysis, the researchers chose BrainAGE, a well-known,
How a Protein Is Linked to Kidney Fibrosis With Age
October 7, 2021
Publishing in Aging, a team of researchers has reported that periostin, a protein that aids in development during the embryonic stage, is linked to kidney problems related to lipid metabolism
Matching an Epigenetic Clock to Physical Function
October 6, 2021
A new, three-year study published in The Journals of Gerontology: Series A examined the relationship between epigenetic clocks and physical performance in older women. Epigenetic clocks and biological age Epigenetic
Engineering Anti-Inflammatory Cells to Fight Arthritis
October 4, 2021
Publishing in Science Advances, a team of researchers has described how a scaffold containing genetically engineered induced pluripotent stem cells (iPSCs) can reduce symptoms in a mouse model of rheumatoid
Some Mutations Increase Cancer Risk by Making Cells Older
October 1, 2021
Cells from the breasts of women with mutations that increase their risk of breast cancer show signs of accelerated aging, according to new research [1]. Accelerated aging may make these
Study Suggests No Theoretical Limit on Human Lifespan
September 30, 2021
According to new research, it may be possible for humans to live 130 years or perhaps longer, but the chances of reaching that age are slim. New findings suggest that
The Effects of Caloric Restriction on Stem Cells
September 29, 2021
A review published in The Malaysian Journal of Medical Sciences has outlined what effects caloric restriction (CR) has on the development and differentiation of stem cells. Stem cells and their
Activity and Diet Shown to Slow Aging (Again)
September 28, 2021
Scientists have used DNA methylation markers to measure the anti-aging effects of healthy diet and physical activity, reaching interesting, if at times contradictory, results [1]. Move, eat healthy, check your
Our Brains’ Metabolism Changes as We Age
September 24, 2021
A study conducted in Sweden and published in Scientific Reports has outlined the relationship between aging and the metabolites present in cerebrospinal fluid (CSF), which cushions and supports the brain
Getting Proteins Right to Live Longer
September 23, 2021
Changing a single amino acid in a single protein boosts the fidelity of protein synthesis, and that is enough to increase lifespan in a variety of organisms, according to new
Dr. Morgan Levine on Building a Better Epigenetic Clock
September 22, 2021
In her lab at Yale, Dr. Morgan Levine tackles some of the most exciting and difficult problems in geroscience. She specializes in bioinformatics and is working on creating and finessing
Senolytics Alleviate Spinal Disc Degeneration in Mice
September 21, 2021
A group of researchers has found that early long-term treatment of mice with the popular senolytic duo dasatinib and quercetin alleviates symptoms of intervertebral disc degeneration, a major age-related cause
Epigenomic Rejuvenation for Restoring Bone Stem Cells
September 17, 2021
Researchers have shown that age-related loss of bone maintenance is caused by changes in gene expression [1]. Perhaps most importantly, those changes can also be reversed and the bone marrow
The Genetic Basis of Telomere Length
October 13, 2021
A new study in Nature Genetics has further illuminated the genetic regulation of telomere length and what implications it may have for various diseases and longevity. Telomeres and aging in humans At one time the hottest topic in aging, telomeres are the protective caps at the
Escaping Stem Cells Exacerbate Age-Related Hair Loss
October 12, 2021
Scientists showed that hair loss happens partially as a result of stem cells escaping from hair follicles. They also shot a stunning time-lapse video of the process. The stem cell cycle Stem cells reside in “stem cell compartments” in various tissues. By differentiating into multiple types
The Link Between Brain Age and Blood Pressure
October 11, 2021
Researchers publishing in Frontiers in Aging Neuroscience have discovered that blood pressure is directly linked to brain aging. The BrainAGE clock For this analysis, the researchers chose BrainAGE, a well-known, machine learning-based biomarker that uses MRI imagery in order to determine age [1]. The researchers of
How a Protein Is Linked to Kidney Fibrosis With Age
October 7, 2021
Publishing in Aging, a team of researchers has reported that periostin, a protein that aids in development during the embryonic stage, is linked to kidney problems related to lipid metabolism in adults. Why does this protein exist? The researchers cite prior studies showing that periostin is
Matching an Epigenetic Clock to Physical Function
October 6, 2021
A new, three-year study published in The Journals of Gerontology: Series A examined the relationship between epigenetic clocks and physical performance in older women. Epigenetic clocks and biological age Epigenetic clocks attempt to estimate age based on measurable DNA modifications. However, not every individual ages at
Engineering Anti-Inflammatory Cells to Fight Arthritis
October 4, 2021
Publishing in Science Advances, a team of researchers has described how a scaffold containing genetically engineered induced pluripotent stem cells (iPSCs) can reduce symptoms in a mouse model of rheumatoid arthritis. The advantage over current drugs Rheumatoid arthritis (RA) is currently treated through drugs that often
Some Mutations Increase Cancer Risk by Making Cells Older
October 1, 2021
Cells from the breasts of women with mutations that increase their risk of breast cancer show signs of accelerated aging, according to new research [1]. Accelerated aging may make these cells worse at suppressing cancer development, offering both an explanation for the effect of these mutations
Study Suggests No Theoretical Limit on Human Lifespan
September 30, 2021
According to new research, it may be possible for humans to live 130 years or perhaps longer, but the chances of reaching that age are slim. New findings suggest that mortality risk plateaus past 110 For many years now, just how long a human being can
The Effects of Caloric Restriction on Stem Cells
September 29, 2021
A review published in The Malaysian Journal of Medical Sciences has outlined what effects caloric restriction (CR) has on the development and differentiation of stem cells. Stem cells and their exhaustion The reviewers began by discussing stem cell exhaustion, a hallmark of aging and a common
Activity and Diet Shown to Slow Aging (Again)
September 28, 2021
Scientists have used DNA methylation markers to measure the anti-aging effects of healthy diet and physical activity, reaching interesting, if at times contradictory, results [1]. Move, eat healthy, check your biological age Physical activity (PA) and healthy diet are two powerful interventions that have time and
Our Brains’ Metabolism Changes as We Age
September 24, 2021
A study conducted in Sweden and published in Scientific Reports has outlined the relationship between aging and the metabolites present in cerebrospinal fluid (CSF), which cushions and supports the brain and spine. A detailed, metabolic analysis The researchers extracted CSF from 41 people aged 20 to
Getting Proteins Right to Live Longer
September 23, 2021
Changing a single amino acid in a single protein boosts the fidelity of protein synthesis, and that is enough to increase lifespan in a variety of organisms, according to new research [1]. Proofreading proteins The loss of proteostasis is one of the hallmarks of aging. However,
Dr. Morgan Levine on Building a Better Epigenetic Clock
September 22, 2021
In her lab at Yale, Dr. Morgan Levine tackles some of the most exciting and difficult problems in geroscience. She specializes in bioinformatics and is working on creating and finessing clocks that measure biological age. We talked with Dr. Levine about her work, the impact that
Senolytics Alleviate Spinal Disc Degeneration in Mice
September 21, 2021
A group of researchers has found that early long-term treatment of mice with the popular senolytic duo dasatinib and quercetin alleviates symptoms of intervertebral disc degeneration, a major age-related cause of disability [1]. Age-related disease with early onset Conventional wisdom says that our spines just were
Epigenomic Rejuvenation for Restoring Bone Stem Cells
September 17, 2021
Researchers have shown that age-related loss of bone maintenance is caused by changes in gene expression [1]. Perhaps most importantly, those changes can also be reversed and the bone marrow stem cells rejuvenated. Bones become weaker as we age as stem cell function declines With advancing