Category: Research
Stem Cell Ovaries Now Functional in Mice
July 29, 2021
The entire ovarian niche of mice can now be generated in vitro from stem cells, as a study recently published in Science shows [1]. The researchers then carried out the
Anxious After Watching “Old”? Relax!
July 28, 2021
Rapid aging is horrifying, but in this retrospective, Elena Milova discusses why this movie scared her less than the rest of the audience. Script Spoiler alert! Several families go to
George Church on Gene Therapies and Longevity
July 28, 2021
Professor of Genetics at Harvard Medical School and one of the most prominent geroscientists, George Church works on gene therapies that can potentially reverse age-related diseases. We had the opportunity
Memory Restored in Aged Mice by Modifying the Brain’s ECM
July 28, 2021
Molecular Psychiatry has recently published a report from the University of Cambridge detailing how the brain’s extracellular matrix (ECM) changes with age, negatively impacting memory, and how modifying the components
Defeating Aging With Aubrey de Grey and Michael Rae
July 27, 2021
We recently caught up with Dr. Aubrey de Grey and Michael Rae from SENS Research Foundation (SRF) about the landscape in the field. We asked them two simple questions, and
A Model Using Four Fatty Acids Predicts Mortality
July 26, 2021
A study published in the American Journal of Clinical Nutrition has shown that a model built on the concentration of four fatty acids predicts mortality in older people at least
Teasing Apart the Effects of Aging and COVID-19
July 22, 2021
Researchers have used a big data approach to disentangle cellular and physiological changes that are specific to COVID-19 from those caused by aging [1]. Identifying these improves our understanding of
Senescent Cells, p65, and a Possible Treatment for Cancer
July 21, 2021
A report in the Journal of Cell Science has outlined different stages of cellular senescence alongside a mechanism that reverses it, along with a potential new treatment for glioblastoma. Old
Enriched Environments Youthen the Brains of Mice
July 20, 2021
A study published in Nature Communications has shown that an environment rich in stimuli changes the epigenetics of the mouse hippocampus, making the brains of aged mice more like those
HDAC Inhibitors Linked to Cellular Senescence
July 19, 2021
A study published in Aging has shown that inhibiting histone deacetylases (HDACs), an approach used for treating cancer and other diseases, can lead to cellular senescence. What is a histone,
Loss of Peptide Not Amyloid Plaques a New Alzheimer’s Target
July 16, 2021
A recent study, led by the University of Cincinnati in collaboration with the Karolinska Institute in Sweden, challenges the popular amyloid hypothesis that has dominated Alzheimer’s research for decades. Amyloid
Engineering Cells to Avoid Immune Detection in Transplants
July 15, 2021
Gene editing can make stem cells invisible to the immune system, making it possible to carry out cell therapy transplants without suppressing the patients’ immune response [1]. Help me help
The Enormous Economic Benefits of Targeting Aging
July 14, 2021
Using Peter Pan, Wolverine, and a powerful economic model, a trio of prominent scientists argues that slowing aging can bring gargantuan economic benefits – an order of magnitude bigger than
NMN Enhances Aerobic Capacity in Amateur Runners
July 14, 2021
A clinical trial of endurance runners recently published in the Journal of the International Society of Sports Nutrition found nicotinamide mononucleotide (NMN) to increase several measures of aerobic capacity. Could
Telomere Loss And The Development Of Fibrosis
July 13, 2021
A new study published in Aging has shown a link between a reduction in telomerase reverse transcriptase (TERT), the gene that allows for telomere maintenance, and the development of myofibroblasts,
Stem Cell Ovaries Now Functional in Mice
July 29, 2021
The entire ovarian niche of mice can now be generated in vitro from stem cells, as a study recently published in Science shows [1]. The researchers then carried out the remarkable feat of fertilizing the generated oocytes and growing healthy, fertile offspring from them. This advance
Anxious After Watching “Old”? Relax!
July 28, 2021
Rapid aging is horrifying, but in this retrospective, Elena Milova discusses why this movie scared her less than the rest of the audience. Script Spoiler alert! Several families go to a hotel in the tropics for a vacation. As any ordinary family, it has its problems
George Church on Gene Therapies and Longevity
July 28, 2021
Professor of Genetics at Harvard Medical School and one of the most prominent geroscientists, George Church works on gene therapies that can potentially reverse age-related diseases. We had the opportunity to interview this prolific researcher and entrepreneur, who is involved in dozens of startups, on topics
Memory Restored in Aged Mice by Modifying the Brain’s ECM
July 28, 2021
Molecular Psychiatry has recently published a report from the University of Cambridge detailing how the brain’s extracellular matrix (ECM) changes with age, negatively impacting memory, and how modifying the components of the brain ECM can revitalize memory in mice [1]. What is neuroplasticity? Neuroplasticity is the
Defeating Aging With Aubrey de Grey and Michael Rae
July 27, 2021
We recently caught up with Dr. Aubrey de Grey and Michael Rae from SENS Research Foundation (SRF) about the landscape in the field. We asked them two simple questions, and they joined forces to give us their combined insights. lifespan.io: First, do you think we can
A Model Using Four Fatty Acids Predicts Mortality
July 26, 2021
A study published in the American Journal of Clinical Nutrition has shown that a model built on the concentration of four fatty acids predicts mortality in older people at least as well as a model that uses smoking and diabetes. A long-term cohort study This study
Teasing Apart the Effects of Aging and COVID-19
July 22, 2021
Researchers have used a big data approach to disentangle cellular and physiological changes that are specific to COVID-19 from those caused by aging [1]. Identifying these improves our understanding of the disease and may help explain why COVID-19 has a more severe effect on older people.
Senescent Cells, p65, and a Possible Treatment for Cancer
July 21, 2021
A report in the Journal of Cell Science has outlined different stages of cellular senescence alongside a mechanism that reverses it, along with a potential new treatment for glioblastoma. Old paradigms in cellular senescence Cellular senescence contributes to aging and age-related diseases, likely primarily through the
Enriched Environments Youthen the Brains of Mice
July 20, 2021
A study published in Nature Communications has shown that an environment rich in stimuli changes the epigenetics of the mouse hippocampus, making the brains of aged mice more like those of young mice [1]. What is an enriched environment? For mice, enriched environments (ENRs) are “large
HDAC Inhibitors Linked to Cellular Senescence
July 19, 2021
A study published in Aging has shown that inhibiting histone deacetylases (HDACs), an approach used for treating cancer and other diseases, can lead to cellular senescence. What is a histone, anyway? In biology, a histone is a protein that binds to DNA in order to control
Loss of Peptide Not Amyloid Plaques a New Alzheimer’s Target
July 16, 2021
A recent study, led by the University of Cincinnati in collaboration with the Karolinska Institute in Sweden, challenges the popular amyloid hypothesis that has dominated Alzheimer’s research for decades. Amyloid accumulation may be the consequence, not the cause Over 100 years ago, Alois Alzheimer originally identified
Engineering Cells to Avoid Immune Detection in Transplants
July 15, 2021
Gene editing can make stem cells invisible to the immune system, making it possible to carry out cell therapy transplants without suppressing the patients’ immune response [1]. Help me help you Cellular therapies involve transplanting cells into a patient to replace the activity of malfunctioning or
The Enormous Economic Benefits of Targeting Aging
July 14, 2021
Using Peter Pan, Wolverine, and a powerful economic model, a trio of prominent scientists argues that slowing aging can bring gargantuan economic benefits – an order of magnitude bigger than previously thought [1]. The marriage of economics and geroscience The paper, published in Nature Aging, looks
NMN Enhances Aerobic Capacity in Amateur Runners
July 14, 2021
A clinical trial of endurance runners recently published in the Journal of the International Society of Sports Nutrition found nicotinamide mononucleotide (NMN) to increase several measures of aerobic capacity. Could NMN and exercise be synergistic? NMN is a NAD+ precursor well known to longevity researchers for
Telomere Loss And The Development Of Fibrosis
July 13, 2021
A new study published in Aging has shown a link between a reduction in telomerase reverse transcriptase (TERT), the gene that allows for telomere maintenance, and the development of myofibroblasts, cells that are a part of organ fibrosis. It also documents the link between telomere attrition