Category: Research
A Single Molecule Can Regenerate the Gut Lining
July 27, 2020
New research from Monash University has shown that a single key molecule responsible for cell adhesion and a variety of other bodily functions is also critical in repairing the gut
A DNA Methylation Clock to Measure Skin Age
July 24, 2020
A team of researchers have developed a tissue-specific clock that can measure the biological age of skin. There is plenty of new evidence that different organs and tissues in our
Why NAD+ Declines During Aging – Part 1
July 23, 2020
There has been considerable debate around the age-related decline of NAD+, particularly regarding whether or not it occurs in humans as it does in other species, such as mice. Today,
Hyperbaric Oxygen Therapy May Reduce Cognitive Decline
July 21, 2020
A group of Israeli scientists led by Prof. Shai Efrati investigated the effects of hyperbaric oxygen therapy (HBOT) on age-related cognitive decline in healthy older adults, and the results were
Genomic Instability May Directly Lead to Diseases of Aging
July 16, 2020
A new perspective published in Cell explains a direct link between genomic instability and age-related diseases [1]. Somatic mutations Mutation is normally explained as the driving force behind evolution, as
The First Precision Gene Editing Tool for Mitochondrial DNA
July 14, 2020
Researchers have developed what can be described as the first precision gene editing tool for mitochondrial DNA (mtDNA). This new tool is different from the well-known CRISPR/Cas9 method of gene
A Blood Factor Boosts Neurogenesis and Cognition
July 13, 2020
By now, the race to discover regenerative factors present in blood has been underway for a number of years, with numerous researchers seeking a “secret sauce” in blood that has
Trimethylamine May be Involved in Vascular Aging
July 10, 2020
Researchers suggest that trimethylamine, a metabolic byproduct that is created when bacteria in the gut break down foods such as red meat, may be a key player in vascular aging.
Selectivity of the Blood-Brain Barrier Changes with Age
July 9, 2020
The mechanisms at work in the blood-brain barrier change with age, affecting the selectivity of this vital interface. The blood-brain barrier The blood-brain barrier is a layer of cells in
Frailty and Age-Related Immune Decline Reversed in Mice
July 8, 2020
Frailty and the decline of the immune system are two typical features of aging, but new research shows that both can be halted and even somewhat reversed using a novel
Repetitions in Our DNA React to Anti-Aging Interventions
July 7, 2020
A group of scientists from Colorado State University has discovered that repetitive elements (REs) in our DNA increase with aging and react to known longevity-promoting interventions [1]. Are REs genomic
Parkinson’s Disease Symptoms Reversed in Mice
July 3, 2020
Researchers have found that blocking the activity of a single gene causes other cell types to become dopamine-producing neurons, a type of neuron that Parkinson’s disease destroys. What is Parkinson’s
Two Proteins Allow LDL Cholesterol into Our Cells
July 2, 2020
Researchers have found out how LDL cholesterol is able to enter our cells with the help of two proteins that form a doorway into the cell. The findings have ramifications
Pilot Study Results Suggest Epigenetic Age Reversal
June 30, 2020
Today, we want to highlight a press release from Ponce de Leon Health that talks about the results of a pilot consumer trial that the company has recently concluded. The
New Evidence of Common Genetic Causes in Age-Related Diseases
June 30, 2020
By using a large UK health databank and advanced methods of statistical analysis, scientists have discovered genetic ties between various age-related diseases and proposed several candidate drugs for upstream intervention.
A Single Molecule Can Regenerate the Gut Lining
July 27, 2020
New research from Monash University has shown that a single key molecule responsible for cell adhesion and a variety of other bodily functions is also critical in repairing the gut lining and that increasing the presence of this molecule accelerates its repair and regeneration. Supercharging stem
A DNA Methylation Clock to Measure Skin Age
July 24, 2020
A team of researchers have developed a tissue-specific clock that can measure the biological age of skin. There is plenty of new evidence that different organs and tissues in our body age at different rates. In particular, the epigenetic state, the pattern of gene expression, of
Why NAD+ Declines During Aging – Part 1
July 23, 2020
There has been considerable debate around the age-related decline of NAD+, particularly regarding whether or not it occurs in humans as it does in other species, such as mice. Today, as part of a two-part special, we are going to be taking a look at some
Hyperbaric Oxygen Therapy May Reduce Cognitive Decline
July 21, 2020
A group of Israeli scientists led by Prof. Shai Efrati investigated the effects of hyperbaric oxygen therapy (HBOT) on age-related cognitive decline in healthy older adults, and the results were promising. The brain is the most metabolically active organ in the body, but it has only
Genomic Instability May Directly Lead to Diseases of Aging
July 16, 2020
A new perspective published in Cell explains a direct link between genomic instability and age-related diseases [1]. Somatic mutations Mutation is normally explained as the driving force behind evolution, as changes in the germ lines of organisms result in beneficial and harmful mutations to organisms. The
The First Precision Gene Editing Tool for Mitochondrial DNA
July 14, 2020
Researchers have developed what can be described as the first precision gene editing tool for mitochondrial DNA (mtDNA). This new tool is different from the well-known CRISPR/Cas9 method of gene editing and should make the study of mitochondrial biology and mitochondrial diseases easier. This new discovery
A Blood Factor Boosts Neurogenesis and Cognition
July 13, 2020
By now, the race to discover regenerative factors present in blood has been underway for a number of years, with numerous researchers seeking a “secret sauce” in blood that has the potential to rejuvenate aged tissues and organs. A fork in the road It is clear
Trimethylamine May be Involved in Vascular Aging
July 10, 2020
Researchers suggest that trimethylamine, a metabolic byproduct that is created when bacteria in the gut break down foods such as red meat, may be a key player in vascular aging. Trimethylamine and vascular aging Some researchers believe that trimethylamine damages our arteries, according to a new
Selectivity of the Blood-Brain Barrier Changes with Age
July 9, 2020
The mechanisms at work in the blood-brain barrier change with age, affecting the selectivity of this vital interface. The blood-brain barrier The blood-brain barrier is a layer of cells in the blood vessels of the brain that prevents molecules in the blood from crossing into the
Frailty and Age-Related Immune Decline Reversed in Mice
July 8, 2020
Frailty and the decline of the immune system are two typical features of aging, but new research shows that both can be halted and even somewhat reversed using a novel cell-based therapy. Frailty and immunosenescence Frailty is something that frequently affects older people, and it ultimately
Repetitions in Our DNA React to Anti-Aging Interventions
July 7, 2020
A group of scientists from Colorado State University has discovered that repetitive elements (REs) in our DNA increase with aging and react to known longevity-promoting interventions [1]. Are REs genomic parasites? At the dawn of genomic research scientists were stunned to learn that as much as
Parkinson’s Disease Symptoms Reversed in Mice
July 3, 2020
Researchers have found that blocking the activity of a single gene causes other cell types to become dopamine-producing neurons, a type of neuron that Parkinson’s disease destroys. What is Parkinson’s disease? Parkinson’s disease is a progressive, age-related, neurodegenerative disease that mainly affects the motor system and
Two Proteins Allow LDL Cholesterol into Our Cells
July 2, 2020
Researchers have found out how LDL cholesterol is able to enter our cells with the help of two proteins that form a doorway into the cell. The findings have ramifications for treating heart disease, which is currently the world’s greatest killer. Revealing how LDL gets into
Pilot Study Results Suggest Epigenetic Age Reversal
June 30, 2020
Today, we want to highlight a press release from Ponce de Leon Health that talks about the results of a pilot consumer trial that the company has recently concluded. The company claims that it has been successful in reducing the epigenetic age of participants by an
New Evidence of Common Genetic Causes in Age-Related Diseases
June 30, 2020
By using a large UK health databank and advanced methods of statistical analysis, scientists have discovered genetic ties between various age-related diseases and proposed several candidate drugs for upstream intervention. Building age-of-onset profiles of diseases The very fact that multitudes of age-related diseases (ARDs) exist alludes