Category: Research
The Gut Microbiome’s Influence on Skeletal Muscle Mass
December 2, 2019
Researcher Dr. Michael Lustgarten has recently published a compact and very readable review that focuses on the role of the gut microbiome and its influence on skeletal muscle mass. The
Positive Results of a Human Trial for Skin Aging
November 27, 2019
The results of a small human clinical trial focused on skin aging have been published, and they are positive. A topical application of rapamycin, an FDA-approved drug that is used
Irresponsible Marketing Surrounds Telomerase Trials
November 26, 2019
Recently, Libella Gene Therapeutics has announced that it will be running a patient-paid trial in Colombia with an eye-watering $1 million USD price tag on enrollment. Patient-paid trial likely to
Gut Microbes Promote Neurogenesis and Longevity Hormone
November 21, 2019
The relationship between health and the microorganisms living in the gut has increasingly reached the spotlight in the last few years, and a new study led by researchers at Nanyang
Disappointing Results for ResTORbio Human Trial
November 18, 2019
ResTORbio announced on Friday 15th that its current phase 3 drug trial for respiratory tract infections did not achieve its primary goal. The drug showed promise in earlier phases of
Excluding Oct4 from OSKM Yields Positive Results
November 8, 2019
A recent open-access study published in Cell Stem Cell has shown that excluding Oct4 from the OSKM cocktail reduces epigenetic aberrations and off-target gene activation. Induced pluripotency and Yamanaka factors
Combination Gene Therapy Treats Many Age-Related Diseases
November 7, 2019
A team of researchers, including renowned geneticist Professor George Church, has published a new paper demonstrating the mitigation of multiple age-related diseases using a multi-target gene therapy. Treating multiple age-related
Tweaking Gut Bacteria to Reduce Cognitive Decline
November 6, 2019
A new paper explores adjusting the types of bacteria in the gut as a potential way to improve health in older people. The microbiome The gut microbiome is a fascinating
Dr. Greg Fahy Appears on The Damage Report
November 5, 2019
Dr. Greg Fahy, Chief Scientific Officer of Intervene Immune, has recently appeared on The Damage Report, a news and current events show that is part of The Young Turks (TYT)
A New Healthcare Framework for Aging Populations
November 4, 2019
A new publication by an international team of scientists has proposed a new healthcare framework to help older people stay healthier for longer by improving the development of therapies that
DNA Damage Leads to Epigenetic Alterations
October 11, 2019
A team of researchers, including Dr. David Sinclair, has recently made a new study available as a preprint prior to peer review and publication in the journal Cell. DNA damage
GenSight Biologics Releases Further Trial Data
October 9, 2019
GenSight Biologics has recently released data showing the effectiveness of GS010, the company’s gene therapy for Leber Hereditary Optic Neuropathy (LHON), a mitochondrial disease that can lead to blindness. Like
The Heterogeneity of Senescent Cells
September 18, 2019
Cellular senescence, discovered in 1961 by Leonard Hayflick and Paul Moorhead, is a state in which cells no longer perform their functions, instead emitting harmful chemicals that turn other cells
Study Results Suggest Human Aging Can Be Reversed
September 6, 2019
A small clinical trial, which was conducted by a team of researchers led by Dr. Greg Fahy, has shown for the first time in humans that reversing biological age may
Telomerase Expression Reduces Senescence and Cancer Risk
September 4, 2019
A joint study by researchers at the National Institutes of Health (NIH) and the University of Maryland (UMD) has revealed a previously undocumented protective function of the telomerase enzyme. Telomerase
The Gut Microbiome’s Influence on Skeletal Muscle Mass
December 2, 2019
Researcher Dr. Michael Lustgarten has recently published a compact and very readable review that focuses on the role of the gut microbiome and its influence on skeletal muscle mass. The gut microbiome The microbiome describes a varied community of bacteria, archaea, eukarya, and viruses that inhabit
Positive Results of a Human Trial for Skin Aging
November 27, 2019
The results of a small human clinical trial focused on skin aging have been published, and they are positive. A topical application of rapamycin, an FDA-approved drug that is used to combat organ rejection during donor transplants and targets the mechanistic target of rapamycin (mTOR) pathway,
Irresponsible Marketing Surrounds Telomerase Trials
November 26, 2019
Recently, Libella Gene Therapeutics has announced that it will be running a patient-paid trial in Colombia with an eye-watering $1 million USD price tag on enrollment. Patient-paid trial likely to cause backlash The topic of patient-paid trials often stirs up considerable debate among the research community,
Gut Microbes Promote Neurogenesis and Longevity Hormone
November 21, 2019
The relationship between health and the microorganisms living in the gut has increasingly reached the spotlight in the last few years, and a new study led by researchers at Nanyang Technological University, Singapore (NTU Singapore) sheds more light on the gut microbiome and how it can
Disappointing Results for ResTORbio Human Trial
November 18, 2019
ResTORbio announced on Friday 15th that its current phase 3 drug trial for respiratory tract infections did not achieve its primary goal. The drug showed promise in earlier phases of testing, but sadly failed to reduce the incidence of respiratory tract infections in patients aged 65
Excluding Oct4 from OSKM Yields Positive Results
November 8, 2019
A recent open-access study published in Cell Stem Cell has shown that excluding Oct4 from the OSKM cocktail reduces epigenetic aberrations and off-target gene activation. Induced pluripotency and Yamanaka factors Pluripotent stem cells are cells that can become other cell types in the body; during natural
Combination Gene Therapy Treats Many Age-Related Diseases
November 7, 2019
A team of researchers, including renowned geneticist Professor George Church, has published a new paper demonstrating the mitigation of multiple age-related diseases using a multi-target gene therapy. Treating multiple age-related diseases at once George Church is a very prominent figure in genetics and aging research, and
Tweaking Gut Bacteria to Reduce Cognitive Decline
November 6, 2019
A new paper explores adjusting the types of bacteria in the gut as a potential way to improve health in older people. The microbiome The gut microbiome is a fascinating and diverse ecosystem filled with a myriad of bacteria, archaea, protists, fungi, and viruses that interact
Dr. Greg Fahy Appears on The Damage Report
November 5, 2019
Dr. Greg Fahy, Chief Scientific Officer of Intervene Immune, has recently appeared on The Damage Report, a news and current events show that is part of The Young Turks (TYT) network. Hosts John Iadarola and Brooke Thomas talked with Dr. Fahy about the recent positive results
A New Healthcare Framework for Aging Populations
November 4, 2019
A new publication by an international team of scientists has proposed a new healthcare framework to help older people stay healthier for longer by improving the development of therapies that target age-related diseases. Society is aging, and we need to change healthcare for the better This
DNA Damage Leads to Epigenetic Alterations
October 11, 2019
A team of researchers, including Dr. David Sinclair, has recently made a new study available as a preprint prior to peer review and publication in the journal Cell. DNA damage and the double-strand break Two of the primary hallmarks of aging are genomic instability, which consists
GenSight Biologics Releases Further Trial Data
October 9, 2019
GenSight Biologics has recently released data showing the effectiveness of GS010, the company’s gene therapy for Leber Hereditary Optic Neuropathy (LHON), a mitochondrial disease that can lead to blindness. Like in previous studies, this therapy had a bilateral effect. Gene Therapy In LHON, the mitochondrial protein
The Heterogeneity of Senescent Cells
September 18, 2019
Cellular senescence, discovered in 1961 by Leonard Hayflick and Paul Moorhead, is a state in which cells no longer perform their functions, instead emitting harmful chemicals that turn other cells senescent. Senescence is primarily caused by telomere shortening and DNA damage, and senescent cells are known
Study Results Suggest Human Aging Can Be Reversed
September 6, 2019
A small clinical trial, which was conducted by a team of researchers led by Dr. Greg Fahy, has shown for the first time in humans that reversing biological age may be possible. The results of TRIIM are in The researchers spent a year running the Thymus
Telomerase Expression Reduces Senescence and Cancer Risk
September 4, 2019
A joint study by researchers at the National Institutes of Health (NIH) and the University of Maryland (UMD) has revealed a previously undocumented protective function of the telomerase enzyme. Telomerase is used by somatic cells too It was thought for a long time that telomerase is