Category: Research
Samumed Begins Phase 3 Trial for Knee Osteoarthritis
May 7, 2019
San Diego-based biotechnology company Samumed has recently announced that it will be moving to phase 3 clinical trials of its drug lorecivivint (SM04690) for the treatment of knee osteoarthritis. What
Bone Marrow Transplants Increase Healthy Lifespan in Mice
May 6, 2019
Stem cell transplants have been of great interest to aging researchers, and, in a new study, they have successfully increased mouse lifespan by using stem cell therapy. While this has
A New Database for Senescent Cells
May 3, 2019
Today, we want to spotlight a new publication that charts the senescence-associated secretory phenotype (SASP), which consists of the various secreted signals given out by senescent cells during aging. Senescent
Reversal of Two Advanced Glycation End Products Achieved
May 2, 2019
Today, we want to highlight a new study that shows, for the first time, that established AGEs can be reversed via therapeutic intervention. What are AGEs? Advanced glycation end products
Success at the Xprize Foundation
May 1, 2019
On April 29th and 30th, the XPRIZE Foundation hosted an event at its headquarters in Culver City, California that could have a profound effect on the evolving landscape of biorejuvenation
NMN Improves Cognitive Function in Aged Mice
April 30, 2019
Researchers have tested nicotinamide mononucleotide on aged mice to see if it can help reverse age-related cognitive decline by improving blood flow in the brain. The brain is a hungry
One Step Closer to Artifical Lymph Nodes
April 25, 2019
Scientists from Johns Hopkins Medicine have reported the successful creation of a special type of gel that mimics the lymph nodes in our bodies. This gel recruits and multiplies T
Reversing Cognitive Decline by Blocking a Single Protein
April 9, 2019
A team of Stanford researchers led by Professor Wyss-Coray set out to find out which genes were linked to age-related cognitive decline. Not only did the researchers find the culprit,
Senolytics Improve Recovery Following a Heart Attack
April 8, 2019
In a new study, researchers show that the presence of senescent cells is an important contributor to aging of the cardiovascular system, particularly the heart [1]. Senescent cells and senolytics
Undoing Aging in the Viewfinder
April 2, 2019
The day after I got back from the Undoing Aging 2019 scientific conference, which was jointly organized by the SENS Research Foundation and Forever Healthy Foundation, Moscow greeted me with
Chronic Inflammation Leads to Toxic NET Buildup
March 26, 2019
A new review discusses how neutrophils release toxic substances into the body under inflammatory conditions, detailing one of the ways in which chronic inflammation causes long-term damage. Casting a deadly
Clearing Senescent Cells Prevents T1 Diabetes in Mice
March 7, 2019
Scientists have shown that the removal of non-dividing senescent cells, which are normally associated with aging, also appears to prevent Type 1 diabetes in diabetic mouse strains. Clearing senescent beta
Samsara Is Developing Autophagy Boosting Therapies
March 6, 2019
Samsara Therapeutics has completed a seed financing round in collaboration with Apollo Ventures, a venture capital company and biotech incubator that supports longevity research and treatments for age-related diseases. Samsara
Epigenetic Alterations and Reprogramming Potential in Aging
March 5, 2019
The role of epigenetics, which determine how your genes are expressed, is being increasingly implicated in aging, as is the potential of therapies that revert epigenetics back to those of
Rejuvenating Aged Brains by Waking Up Dormant Stem Cells
March 4, 2019
Researchers from the University of Luxembourg and the German Cancer Research Center have rejuvenated stem cells in the brains of old mice. The rejuvenated stem cells appear to improve regeneration
Samumed Begins Phase 3 Trial for Knee Osteoarthritis
May 7, 2019
San Diego-based biotechnology company Samumed has recently announced that it will be moving to phase 3 clinical trials of its drug lorecivivint (SM04690) for the treatment of knee osteoarthritis. What is osteoarthritis? Osteoarthritis is the most common form of arthritis in the knee and a leading
Bone Marrow Transplants Increase Healthy Lifespan in Mice
May 6, 2019
Stem cell transplants have been of great interest to aging researchers, and, in a new study, they have successfully increased mouse lifespan by using stem cell therapy. While this has been previously achieved, this experiment was more refined than older studies and sheds new light on
A New Database for Senescent Cells
May 3, 2019
Today, we want to spotlight a new publication that charts the senescence-associated secretory phenotype (SASP), which consists of the various secreted signals given out by senescent cells during aging. Senescent cells and the SASP As we get older, an increasing number of our cells enter into
Reversal of Two Advanced Glycation End Products Achieved
May 2, 2019
Today, we want to highlight a new study that shows, for the first time, that established AGEs can be reversed via therapeutic intervention. What are AGEs? Advanced glycation end products (AGEs) are harmful compounds that are created when proteins or fats combine with sugars in the
Success at the Xprize Foundation
May 1, 2019
On April 29th and 30th, the XPRIZE Foundation hosted an event at its headquarters in Culver City, California that could have a profound effect on the evolving landscape of biorejuvenation research: the Future of Longevity Impact Roadmap Lab. For those unfamiliar, the XPRIZE Foundation is famous
NMN Improves Cognitive Function in Aged Mice
April 30, 2019
Researchers have tested nicotinamide mononucleotide on aged mice to see if it can help reverse age-related cognitive decline by improving blood flow in the brain. The brain is a hungry organ Healthy brain function relies on efficient cerebral blood flow (CBF) to wash away harmful waste
One Step Closer to Artifical Lymph Nodes
April 25, 2019
Scientists from Johns Hopkins Medicine have reported the successful creation of a special type of gel that mimics the lymph nodes in our bodies. This gel recruits and multiplies T cells just like actual lymph nodes do, so it could help in the fight against cancer
Reversing Cognitive Decline by Blocking a Single Protein
April 9, 2019
A team of Stanford researchers led by Professor Wyss-Coray set out to find out which genes were linked to age-related cognitive decline. Not only did the researchers find the culprit, they were able to reverse cognitive decline and rejuvenate aged mouse brains. Searching for the cause
Senolytics Improve Recovery Following a Heart Attack
April 8, 2019
In a new study, researchers show that the presence of senescent cells is an important contributor to aging of the cardiovascular system, particularly the heart [1]. Senescent cells and senolytics As your body ages, increasing amounts of your cells enter into a state of senescence. Senescent
Undoing Aging in the Viewfinder
April 2, 2019
The day after I got back from the Undoing Aging 2019 scientific conference, which was jointly organized by the SENS Research Foundation and Forever Healthy Foundation, Moscow greeted me with the first sunny days of the spring. Still tired and lacking sleep, but happy and inspired,
Chronic Inflammation Leads to Toxic NET Buildup
March 26, 2019
A new review discusses how neutrophils release toxic substances into the body under inflammatory conditions, detailing one of the ways in which chronic inflammation causes long-term damage. Casting a deadly NET As we age, we suffer from the ever-increasing chronic inflammation known as inflammaging. This persistent,
Clearing Senescent Cells Prevents T1 Diabetes in Mice
March 7, 2019
Scientists have shown that the removal of non-dividing senescent cells, which are normally associated with aging, also appears to prevent Type 1 diabetes in diabetic mouse strains. Clearing senescent beta cells prevents T1 diabetes Type 1 diabetes (T1D) is a chronic condition in which the pancreas
Samsara Is Developing Autophagy Boosting Therapies
March 6, 2019
Samsara Therapeutics has completed a seed financing round in collaboration with Apollo Ventures, a venture capital company and biotech incubator that supports longevity research and treatments for age-related diseases. Samsara Therapeutics, Inc. (“Samsara,”) a platform biotechnology startup engaged in the discovery and development of compounds that
Epigenetic Alterations and Reprogramming Potential in Aging
March 5, 2019
The role of epigenetics, which determine how your genes are expressed, is being increasingly implicated in aging, as is the potential of therapies that revert epigenetics back to those of a younger person. What are epigenetic alterations? The DNA in each of our cells is identical,
Rejuvenating Aged Brains by Waking Up Dormant Stem Cells
March 4, 2019
Researchers from the University of Luxembourg and the German Cancer Research Center have rejuvenated stem cells in the brains of old mice. The rejuvenated stem cells appear to improve regeneration in areas of damaged or diseased brain tissue. A new way to model stem cells A