Tag: ApoE3

According to a new study, a special protein disposal system, currently found only in neurons, is linked to central hallmarks of Alzheimer’s disease [1]. The membranal proteasome Loss of ProteostasisThe loss of proteostasis is the failure of the protein-building machinery of the cell and the accumulation of misfolded proteins, which is one of the root...

The pro-Alzheimer's allele APOE4 makes hippocampal neurons in mice smaller and hyperexcitable. This effect, which resembles epilepsy and accelerated aging, can be mitigated by manipulating a neuronal protein [1]. Before symptoms arise Alzheimer's disease begins long before symptoms appear, building silently for decades. The single strongest genetic risk factor for the common, late-onset form of...

According to a new study, as many as 90% of Alzheimer’s cases can be attributed to “suboptimal” variants of the APOE gene. These results highlight the gene’s importance for Alzheimer’s prevention [1]. Three alleles of APOE A growing amount of research links Alzheimer’s disease to the gene APOE, which codes for apolipoprotein E [2]. This...

A new study suggests that the gene variant APOE4 promotes Alzheimer’s disease by increasing gliosis, but this effect can be blocked by inhibiting the protein HMGB1 [1]. The dreaded E4 While scientists still do not know the precise causes of Alzheimer’s disease or how to treat it, a person's APOE gene variant is highly predictive...

Scientists studying people with autosomal dominant Alzheimer’s disease have found a genetic variant that is associated with decades of stalled onset [1]. The predictable Alzheimer’s Scientists still do not know what causes most cases of Alzheimer's, although certain genetic variants (most notably APOE4) have been shown to increase the risk of onset [2]. However, there...

In a new study published in Nature Aging, scientists have shown that targeted ablation of neuronal APOE4, which produces the ApoE4 protein, significantly protects against Alzheimer’s disease in a mouse model [1]. The dreadful allele An infamous variant of the APOE gene, APOE4, is the strongest risk factor for late-onset Alzheimer’s disease [2]. People heterozygous...