Tag: Cholesterol

We have spoken with Reason from Repair Biotechnologies about his company's lead candidate, REP-0004, a drug targeting the liver to reduce excess intracellular free cholesterol. The FDA has granted Repair Bio an orphan drug indication, and the company is aiming for clinical trials by mid-2027. Our conversation also touches on the regulatory challenges and the...

A new Phase 1 trial produced encouraging safety and efficacy results for a CRISPR-based gene therapy that silences a gene important for lipid regulation. This therapy might increase adherence and reduce side effects [1]. Addressing the adherence problem High levels of LDL cholesterol (LDL-C) and triglycerides are a major risk factor for cardiovascular disease and...

Some brain regions are more vulnerable to Alzheimer’s disease than others. A new study suggests that this might be due to how they uptake cholesterol [1]. Why do some parts of the brain succumb earlier? Despite decades of research and vast amounts of funding, scientists still have limited understanding of how Alzheimer’s disease develops and...

A new observational study suggests that lower LDL cholesterol levels are not necessarily better. Instead, the ratio of triglycerides to HDL may be more important [1]. Putting common wisdom to the test LDL cholesterol is largely considered harmful, but lower levels might not be beneficial according to a new study by researchers from the University...

A vast new study connects plant-based diets with various health benefits, including in cardiovascular diseases and cancer [1]. What exactly is healthy eating? Diet is one of the most powerful anti-aging interventions available today, but nutrition is also an extremely hard topic to analyze. Food we ingest contains tens of thousands of nutrients, and numerous...

In a randomized controlled trial, eight weeks of healthy vegan eating, but not of healthy omnivorous eating, led to weight loss and significant improvements in LDL cholesterol and insulin levels in a middle-aged twin study [1]. A tale of two diets Most of our knowledge about the health effects of various diets comes from epidemiological...