Tag: Glycans

A recent study suggests that hyperglycosylation in brain tissue can be a hallmark of Alzheimer’s disease [1]. Lesser-known Alzheimer’s molecular features Pathological deposits of amyloid-β plaques and tau tangles in the brain are probably the most well-known features of Alzheimer’s disease. However, Alzheimer’s also involves various metabolism-related pathologies, such as alterations in glucose metabolism [2],...

Scientists have reported a breakthrough in treating solid tumor cancers using a Velcro-like tool that targets glycans, surface sugars especially abundant in cancer cells. This potentially off-the-shelf therapy does not need adjustment to individual cancer types or patients. No sugarcoating this Antibody-based cancer immunotherapies, such as chimeric antigen receptor T (CAR-T) cells were once hailed...

In a new review published in Clinica Chimica Acta, researchers from the University of Zagreb discuss immunoglobulin G glycans, the changes that their composition undergoes with aging, and their potential as biomarkers of aging [1]. Glycans are not AGEs One of the review's co-authors is Prof. Gordan Lauc, who gave a presentation on the importance...