Category: News
A Gene That Keeps Cells Under Control
July 24, 2025
Researchers publishing in Cell Stem Cell have investigated the function of the gene DNMT3A and found that it has wide-ranging effects beyond methylation. More effects than expected Clonal hematopoiesis (CH),
Organ-Specific Aging Analysis Reveals Disease Connections
July 23, 2025
A recent study explored the differences in the speed of organ aging. The researchers have built models that can predict the odds of diseases and mortality risk based on organ-specific
FDA-Approved Drug Combo Rescues Alzheimer’s in Mice
July 22, 2025
Scientists have creatively used large databases of existing FDA-approved drugs and electronic medical records to locate candidates that are potentially effective against Alzheimer’s [1]. New approaches needed Many previously discovered
Vesicles From Antler Cells Restore Bone in Monkeys
July 21, 2025
Researchers publishing in Nature Aging have discovered that extracellular vesicles (EVs) derived from antler blastema progenitor cells (ABPCs) restore bone mass to rhesus macaques. Finding the most effective EVs In
AI Reveals a Hidden Effect in a Failed Alzheimer’s Trial
July 18, 2025
Scientists have created an AI model that stratifies Alzheimer’s patients into subgroups that progress slowly or rapidly. When applied to a real-world failed trial, it revealed a robust effect in
Engineered Stem Cells Reduce Lung Fibrosis in Mice
July 17, 2025
In Molecular Therapy, researchers have described their creation of cells that express the regenerative factor GDF11 and found that they ameliorate fibrosis in a mouse model. Context-dependent benefits Like sirtuins
A Hallucinogenic Mushroom Compound Extends Mouse Lifespan
July 16, 2025
Researchers investigated psilocybin, a psychedelic compound found in hallucinogenic mushrooms, for its anti-aging properties. They found that it extends cellular and organismal lifespan, even when administered later in life [1].
The 2025 Longevity Summit Dublin
July 15, 2025
The 2025 Longevity Summit Dublin was held in July, and we have the highlights from the event for you along with the latest research updates and news from the conference.
Non-Toxic Stem Cell Transplantation Prevents Cancer in Mice
July 15, 2025
Scientists have developed a protocol for hematopoietic stem cell transplantation that reconstructs a healthy blood system and prevents blood cancers in old mice while also reducing toxicity [1]. The blood
How Blood-Brain Barrier Leaks Make Parkinson’s Worse
July 14, 2025
Researchers have discovered how α-synuclein (α-syn), a key protein in Parkinson’s disease and Lewy body dementia, leads to inflammation and disruption of the axons in the brain. Failure of the
Scientists Successfully Edit Mitochondrial DNA
July 11, 2025
A new study demonstrates that novel gene-editing tools can correct disease-causing mutations in mitochondrial DNA in primary human cells [1]. Smaller editing tools needed Genome-editing tools such as CRISPR were
Senolytics May Affect Inflammation-Related Cognitive Decline
July 10, 2025
Researchers have found that inflamed, senescent microglia prune too many synapses in the hippocampus and demonstrated that a senolytic compound can ameliorate this process in Aging Cell. Some synapse pruning
Gabriel Cian on Investment and the 2060 Longevity Forum
July 10, 2025
In this Lifespan interview, we speak with Gabriel Cian, founder of the 2060 Longevity Forum, about how his background in software shaped his views on healthspan innovation, the forum’s approach
Molecular Similarities Between Cigarette Smoking and Aging
July 9, 2025
Researchers have analyzed molecular patterns from different tissues obtained from over 700 people and learned that smoking acts as an aging accelerator and involves molecular changes in tissues beyond those
Inflammaging Might Not Be Universal Across Populations
July 8, 2025
By comparing data from industrialized and non-industrialized societies, a new study calls into question some assumptions about the relationship between inflammation and aging [1]. Harmful protection Inflammation accompanies us throughout
A Gene That Keeps Cells Under Control
July 24, 2025
Researchers publishing in Cell Stem Cell have investigated the function of the gene DNMT3A and found that it has wide-ranging effects beyond methylation. More effects than expected Clonal hematopoiesis (CH), which occurs when stem cells create large numbers of cells with the same mutation, is linked
Organ-Specific Aging Analysis Reveals Disease Connections
July 23, 2025
A recent study explored the differences in the speed of organ aging. The researchers have built models that can predict the odds of diseases and mortality risk based on organ-specific proteins found in plasma [1]. Not all organs age equally Since each organ in the human
FDA-Approved Drug Combo Rescues Alzheimer’s in Mice
July 22, 2025
Scientists have creatively used large databases of existing FDA-approved drugs and electronic medical records to locate candidates that are potentially effective against Alzheimer’s [1]. New approaches needed Many previously discovered drugs may be effective beyond their original indications, but it is challenging to match them to
Vesicles From Antler Cells Restore Bone in Monkeys
July 21, 2025
Researchers publishing in Nature Aging have discovered that extracellular vesicles (EVs) derived from antler blastema progenitor cells (ABPCs) restore bone mass to rhesus macaques. Finding the most effective EVs In the world of rejuvenation research, EVs are nothing new. We have covered them extensively, as studies
AI Reveals a Hidden Effect in a Failed Alzheimer’s Trial
July 18, 2025
Scientists have created an AI model that stratifies Alzheimer’s patients into subgroups that progress slowly or rapidly. When applied to a real-world failed trial, it revealed a robust effect in the former subgroup [1]. Stratify and conquer Drugs don’t work for everyone equally. Unfortunately, clinical trials
Engineered Stem Cells Reduce Lung Fibrosis in Mice
July 17, 2025
In Molecular Therapy, researchers have described their creation of cells that express the regenerative factor GDF11 and found that they ameliorate fibrosis in a mouse model. Context-dependent benefits Like sirtuins and klotho, GDF11 is a biochemical factor that has been heavily investigated in the context of
A Hallucinogenic Mushroom Compound Extends Mouse Lifespan
July 16, 2025
Researchers investigated psilocybin, a psychedelic compound found in hallucinogenic mushrooms, for its anti-aging properties. They found that it extends cellular and organismal lifespan, even when administered later in life [1]. From ancient times to contemporary therapies Hallucinogenic mushrooms have a long history of use, reaching back
The 2025 Longevity Summit Dublin
July 15, 2025
The 2025 Longevity Summit Dublin was held in July, and we have the highlights from the event for you along with the latest research updates and news from the conference. The Summit was founded by Aubrey de Grey and Martin O’Dea in 2022 and combines a
Non-Toxic Stem Cell Transplantation Prevents Cancer in Mice
July 15, 2025
Scientists have developed a protocol for hematopoietic stem cell transplantation that reconstructs a healthy blood system and prevents blood cancers in old mice while also reducing toxicity [1]. The blood factory Hematopoietic stem cells (HSCs) work hard for our entire lives, producing vast numbers of various
How Blood-Brain Barrier Leaks Make Parkinson’s Worse
July 14, 2025
Researchers have discovered how α-synuclein (α-syn), a key protein in Parkinson’s disease and Lewy body dementia, leads to inflammation and disruption of the axons in the brain. Failure of the barrier Unlike other organs, the brain is heavily protected from many compounds in the bloodstream in
Scientists Successfully Edit Mitochondrial DNA
July 11, 2025
A new study demonstrates that novel gene-editing tools can correct disease-causing mutations in mitochondrial DNA in primary human cells [1]. Smaller editing tools needed Genome-editing tools such as CRISPR were one of the greatest scientific breakthroughs of this century. However, they are only good for editing
Senolytics May Affect Inflammation-Related Cognitive Decline
July 10, 2025
Researchers have found that inflamed, senescent microglia prune too many synapses in the hippocampus and demonstrated that a senolytic compound can ameliorate this process in Aging Cell. Some synapse pruning is normal During brain development, the resident immune cells of the brain (microglia) prune unneeded synapses
Gabriel Cian on Investment and the 2060 Longevity Forum
July 10, 2025
In this Lifespan interview, we speak with Gabriel Cian, founder of the 2060 Longevity Forum, about how his background in software shaped his views on healthspan innovation, the forum’s approach to scientific and investment credibility, and what he sees as the biggest bottlenecks and opportunities facing
Molecular Similarities Between Cigarette Smoking and Aging
July 9, 2025
Researchers have analyzed molecular patterns from different tissues obtained from over 700 people and learned that smoking acts as an aging accelerator and involves molecular changes in tissues beyond those directly exposed to cigarette smoke [1]. Millions of preventable deaths Despite campaigns aimed at the reduction
Inflammaging Might Not Be Universal Across Populations
July 8, 2025
By comparing data from industrialized and non-industrialized societies, a new study calls into question some assumptions about the relationship between inflammation and aging [1]. Harmful protection Inflammation accompanies us throughout our entire lives. Without it, we would not be able to fight off pathogens. Yet, inflammation