Category: News
A Klotho Gene Therapy Extends Life in Male Mice
March 6, 2025
In Molecular Therapy, a team of researchers has described how increasing the expression of a form of Klotho, a protein that has been frequently found to have rejuvenative effects, leads
Ginkgolide B Improves Healthspan and Lifespan in Female Mice
March 5, 2025
The authors of a recent study describe Ginkgolide B, a compound with senotherapeutic potential that improved muscle health, metabolism, frailty, inflammation, and senescence metrics and increased lifespan in female mice
Genes Affect Aging and Mortality Less Than Extrinsic Factors
March 4, 2025
A massive study from the University of Oxford has evaluated the relative impact of genetic and non-genetic factors on aging, mortality, and disease prevalence. A deeper dive The question of
Rejuvenation Roundup February 2025
March 3, 2025
February might be the shortest month of the year, but it still has room for plenty of research and advancements. Here’s what’s happened over the last four weeks. Interviews Junevity
A Protein That Controls Senescent Cell Structure
February 28, 2025
Researchers publishing in Cellular Signaling have explained how the protein AP2A1 affects stress fibers that change with cellular senescence. Stress fibers Stress fibers naturally hold cells into their proper shape.
Junevity Is Silencing RNA to Treat Obesity and Diabetes
February 27, 2025
Some longevity biotech companies fit neatly into one of the big buckets we have in this field, like senolytics or cellular reprogramming. Others, such as Junevity, a small spin-out from
Effects of Estradiol and Progesterone on Knee Osteoarthritis
February 26, 2025
Recent research has addressed menopause-related molecular processes that impact the high prevalence of knee osteoarthritis in post-menopausal women. Restoration of female sex hormones in a post-menopausal mouse model improved joint
Receiving Care in Your Language Linked to Lower Health Risks
February 25, 2025
A new study suggests that people with hypertension who receive care in their preferred language are less likely to have a major cardiovascular event or die from any cause [1].
A Generative, Foundational AI Model for Genetics
February 24, 2025
The Arc Institute, a nonprofit research organization, has published a manuscript on its creation of Evo 2, an AI foundation model that is capable of both understanding and building full
The Underexplored Applications of Longevity Biotechnology
February 24, 2025
No other human endeavor today holds more promise than understanding and targeting aging. The molecular mechanisms that drive aging impact overall vigor, environmental stress resistance, reproductive health, and broad disease
Young Plasma Decreases Inflammation After Surgery in Trial
February 20, 2025
In the Journal of Translational Medicine, researchers have published the results of a randomized, controlled clinical trial demonstrating that plasma proteins from young donors have beneficial effects against inflammation in
Repurposing Drugs to Lower Dementia Risk
February 19, 2025
The authors of a recent review analyzed the results of 14 studies that included 139 million people to identify patterns that connect dementia risk to commonly used medications [1]. Finding
Impressions from Hevolution’s Global Healthspan Summit 2025
February 18, 2025
These are some of the best talks from the largest healthspan conference in the world, which was held for the third time in Riyadh by the Hevolution Foundation. Young and
A Key Protein for Tendon Health
February 17, 2025
Researchers publishing in Matrix Biology Plus have discovered that cochlin, a protein that decreases with age, is vital for the health of tendons. Tendons require a healthy extracellular matrix Previous
A Potential New Target for Normal Brain Aging
February 13, 2025
Yesterday in Aging Cell, researchers published their findings that using gene therapy to overexpress a synaptic promoter increases cognitive ability in ordinary, middle-aged mice. Hevin vs. SPARC Astrocytes are general-purpose
A Klotho Gene Therapy Extends Life in Male Mice
March 6, 2025
In Molecular Therapy, a team of researchers has described how increasing the expression of a form of Klotho, a protein that has been frequently found to have rejuvenative effects, leads to longer lifespans in male mice. Klotho has various forms In their introduction, the researchers distinguish
Ginkgolide B Improves Healthspan and Lifespan in Female Mice
March 5, 2025
The authors of a recent study describe Ginkgolide B, a compound with senotherapeutic potential that improved muscle health, metabolism, frailty, inflammation, and senescence metrics and increased lifespan in female mice [1]. From East Asia to the clinic Ginkgolide B is a compound that can be extracted
Genes Affect Aging and Mortality Less Than Extrinsic Factors
March 4, 2025
A massive study from the University of Oxford has evaluated the relative impact of genetic and non-genetic factors on aging, mortality, and disease prevalence. A deeper dive The question of how strongly genes affect our longevity has been asked before, and the emerging answer is not
Rejuvenation Roundup February 2025
March 3, 2025
February might be the shortest month of the year, but it still has room for plenty of research and advancements. Here’s what’s happened over the last four weeks. Interviews Junevity Is Silencing RNA to Treat Obesity and Diabetes: Some longevity biotech companies fit neatly into one
A Protein That Controls Senescent Cell Structure
February 28, 2025
Researchers publishing in Cellular Signaling have explained how the protein AP2A1 affects stress fibers that change with cellular senescence. Stress fibers Stress fibers naturally hold cells into their proper shape. They are made out of the common protein actin and linked together by α-actinin and a
Junevity Is Silencing RNA to Treat Obesity and Diabetes
February 27, 2025
Some longevity biotech companies fit neatly into one of the big buckets we have in this field, like senolytics or cellular reprogramming. Others, such as Junevity, a small spin-out from the University of California, San Francisco, dare to walk an unbeaten path. Junevity pursues the ambitious
Effects of Estradiol and Progesterone on Knee Osteoarthritis
February 26, 2025
Recent research has addressed menopause-related molecular processes that impact the high prevalence of knee osteoarthritis in post-menopausal women. Restoration of female sex hormones in a post-menopausal mouse model improved joint health [1]. A centuries-old observation The authors start the article with a quote from the English
Receiving Care in Your Language Linked to Lower Health Risks
February 25, 2025
A new study suggests that people with hypertension who receive care in their preferred language are less likely to have a major cardiovascular event or die from any cause [1]. Let’s find a common language Communication between the doctor and the patient is important, and it
A Generative, Foundational AI Model for Genetics
February 24, 2025
The Arc Institute, a nonprofit research organization, has published a manuscript on its creation of Evo 2, an AI foundation model that is capable of both understanding and building full genomes of organisms. A new step in understanding biology The authors of this paper, a group
The Underexplored Applications of Longevity Biotechnology
February 24, 2025
No other human endeavor today holds more promise than understanding and targeting aging. The molecular mechanisms that drive aging impact overall vigor, environmental stress resistance, reproductive health, and broad disease risk, and they fundamentally change what life means by radically changing our relationship to death. Intriguingly,
Young Plasma Decreases Inflammation After Surgery in Trial
February 20, 2025
In the Journal of Translational Medicine, researchers have published the results of a randomized, controlled clinical trial demonstrating that plasma proteins from young donors have beneficial effects against inflammation in a surgical context. From parabiosis experiments to the clinic It has been documented for two decades
Repurposing Drugs to Lower Dementia Risk
February 19, 2025
The authors of a recent review analyzed the results of 14 studies that included 139 million people to identify patterns that connect dementia risk to commonly used medications [1]. Finding a new purpose Despite its prevalence in the elderly population, there is a lack of effective
Impressions from Hevolution’s Global Healthspan Summit 2025
February 18, 2025
These are some of the best talks from the largest healthspan conference in the world, which was held for the third time in Riyadh by the Hevolution Foundation. Young and restless The Hevolution Foundation has only been around for three years. Before that, Saudi Arabia, its
A Key Protein for Tendon Health
February 17, 2025
Researchers publishing in Matrix Biology Plus have discovered that cochlin, a protein that decreases with age, is vital for the health of tendons. Tendons require a healthy extracellular matrix Previous work has found that tendon tissues, which link muscle to bone, require a healthy extracellular matrix
A Potential New Target for Normal Brain Aging
February 13, 2025
Yesterday in Aging Cell, researchers published their findings that using gene therapy to overexpress a synaptic promoter increases cognitive ability in ordinary, middle-aged mice. Hevin vs. SPARC Astrocytes are general-purpose helper cells of the brain, and one of their tasks is to maintain synapse structure [1].