Category: News
Skin Aging of the Naked Mole Rat
June 17, 2022
Naked mole rats are long-lived rodents famous for their resistance to cancer and sustained healthy lifespan. In a new study published in the Journal of Investigative Dermatology, researchers have shown
Blood Donation Slows Skin Aging in Mice
June 17, 2022
Scientists have shown that blood donation strongly affects skin aging in mice, probably by lowering the levels of toxic free iron [1]. The good bloodshed Before the dawn of modern
Dietary Restriction Delays Eye Aging in Flies
June 16, 2022
A new study published in Nature has reported on how caloric restriction, circadian rhythms, and molecular clocks interact to affect the ocular health and lifespan of fruit flies. Circadian rhythms,
Scientists Discover Therapy Against Aggressive Breast Cancer
June 14, 2022
Publishing in Nature, scientists from the University of Texas report the discovery of a small molecule that can stop an especially aggressive subtype of breast cancer [1]. The deadliest kind
Vitamin D Supplements Linked to Slower Epigenetic Aging
June 13, 2022
Using a Berlin cohort, a study published in GeroScience has uncovered a link between Vitamin D supplementation and a reduction of epigenetic age. On the back of previous work This
Mediterranean Diet Associated with Lifespan and Healthspan
June 10, 2022
Scientists have shown yet again that adherence to the Mediterranean diet is positively correlated with longer and healthier lives – this time in a large-scale population study spanning 130 countries
Urolithin A Improves Muscle Strength in Middle-Aged Adults
June 10, 2022
A new study published in Cell Reports Medicine shows that urolithin A supplementation improves muscle strength, fitness, and mitochondrial health in overweight, middle-aged adults [1]. Mitophagy in aging and in
Drug Leads to Drastic Weight Loss With Diet and Exercise
June 9, 2022
A large Phase 3 study published in the New England Journal of Medicine shows that an existing drug combined with a healthy diet and mild exercise leads to an average
Spermidine Human Trial Results Fail to Impress
June 8, 2022
The results of a human clinical trial for spermidine against cognitive decline have recently been published, but the results are not positive. What is spermidine? Spermidine is a polyamine, meaning
Antibody Therapy Alone Eliminates Certain Rectal Cancers
June 7, 2022
Researchers publishing in the New England Journal of Medicine have been able to completely eliminate stage 2 and 3 rectal tumors with a single monoclonal antibody drug [1]. Therapy comes
Senolytic Interventions Ameliorate Radiation Damage in Mice
June 6, 2022
In their publication in eLife Sciences, researchers at Newcastle University in the UK have illustrated how radiation-induced damage can be somewhat ameliorated with senolytics. These researchers focused on navitoclax along
Modifiying Retrons for Better Gene Editing
June 3, 2022
A new study published in Nature Chemical Biology has described an advancement in the use of retrons, a novel method of genetic engineering that may become superior to CRISPR technology.
NMN Human Trial Results Published
June 2, 2022
The data from a multicenter NMN clinical trial have been published with some very modest but still interesting results [1]. What is NMN? NMN is short for nicotinamide mononucleotide, a
Fighting Alzheimer’s Disease with Increased Autophagy
June 1, 2022
In a new study published in Pharmacology Biochemistry and Behavior, researchers have shown that a combination of two compounds targeting different autophagy pathways is effective in fighting the pathological mechanism
Rejuvenation Roundup May 2022
June 1, 2022
Two days ago, the United States honored its fallen veterans. How many of those heroes came home, having survived the horrors of war, only to have their own bodies betray
Skin Aging of the Naked Mole Rat
June 17, 2022
Naked mole rats are long-lived rodents famous for their resistance to cancer and sustained healthy lifespan. In a new study published in the Journal of Investigative Dermatology, researchers have shown that the skin of older members of this species is characterized by high expression of longevity-associated
Blood Donation Slows Skin Aging in Mice
June 17, 2022
Scientists have shown that blood donation strongly affects skin aging in mice, probably by lowering the levels of toxic free iron [1]. The good bloodshed Before the dawn of modern medicine, bloodletting was one of the favorite arrows in medieval doctors’ quivers. Of course, it was
Dietary Restriction Delays Eye Aging in Flies
June 16, 2022
A new study published in Nature has reported on how caloric restriction, circadian rhythms, and molecular clocks interact to affect the ocular health and lifespan of fruit flies. Circadian rhythms, clock genes, and photoreceptors The researchers begin their paper by discussing the concept of circadian rhythms,
Scientists Discover Therapy Against Aggressive Breast Cancer
June 14, 2022
Publishing in Nature, scientists from the University of Texas report the discovery of a small molecule that can stop an especially aggressive subtype of breast cancer [1]. The deadliest kind Breast cancer remains the fourth deadliest type of cancer, claiming more than 40 thousand victims a
Vitamin D Supplements Linked to Slower Epigenetic Aging
June 13, 2022
Using a Berlin cohort, a study published in GeroScience has uncovered a link between Vitamin D supplementation and a reduction of epigenetic age. On the back of previous work This study’s cohort consisted of 60- to 85-year-old participants in the Berlin Aging Study II (BASE-II). The
Mediterranean Diet Associated with Lifespan and Healthspan
June 10, 2022
Scientists have shown yet again that adherence to the Mediterranean diet is positively correlated with longer and healthier lives – this time in a large-scale population study spanning 130 countries [1]. Olive oil in, meat mostly out The so-called Mediterranean diet is one of the most
Urolithin A Improves Muscle Strength in Middle-Aged Adults
June 10, 2022
A new study published in Cell Reports Medicine shows that urolithin A supplementation improves muscle strength, fitness, and mitochondrial health in overweight, middle-aged adults [1]. Mitophagy in aging and in disease Mitochondrial dysfunction is one of the hallmarks of aging. It is associated with age-related skeletal
Drug Leads to Drastic Weight Loss With Diet and Exercise
June 9, 2022
A large Phase 3 study published in the New England Journal of Medicine shows that an existing drug combined with a healthy diet and mild exercise leads to an average weight loss of 20% [1]. Diet and exercise are not always enough Being a known comorbid
Spermidine Human Trial Results Fail to Impress
June 8, 2022
The results of a human clinical trial for spermidine against cognitive decline have recently been published, but the results are not positive. What is spermidine? Spermidine is a polyamine, meaning it has two or more primary amino groups. It is naturally occurring and is widely encountered
Antibody Therapy Alone Eliminates Certain Rectal Cancers
June 7, 2022
Researchers publishing in the New England Journal of Medicine have been able to completely eliminate stage 2 and 3 rectal tumors with a single monoclonal antibody drug [1]. Therapy comes with a price If we leave out skin cancers, colorectal cancer is the third most commonly
Senolytic Interventions Ameliorate Radiation Damage in Mice
June 6, 2022
In their publication in eLife Sciences, researchers at Newcastle University in the UK have illustrated how radiation-induced damage can be somewhat ameliorated with senolytics. These researchers focused on navitoclax along with the well-known combination of dasatinib and quercetin. A focus on cancer survivors The researchers begin
Modifiying Retrons for Better Gene Editing
June 3, 2022
A new study published in Nature Chemical Biology has described an advancement in the use of retrons, a novel method of genetic engineering that may become superior to CRISPR technology. A new solution for an old problem The researchers begin their paper by pointing out some
NMN Human Trial Results Published
June 2, 2022
The data from a multicenter NMN clinical trial have been published with some very modest but still interesting results [1]. What is NMN? NMN is short for nicotinamide mononucleotide, a naturally occurring molecule present in all species. It is a precursor of nicotinamide adenine dinucleotide (NAD+),
Fighting Alzheimer’s Disease with Increased Autophagy
June 1, 2022
In a new study published in Pharmacology Biochemistry and Behavior, researchers have shown that a combination of two compounds targeting different autophagy pathways is effective in fighting the pathological mechanism of Alzheimer’s disease in a mouse model [1]. Cleaning up is a big deal The accumulation
Rejuvenation Roundup May 2022
June 1, 2022
Two days ago, the United States honored its fallen veterans. How many of those heroes came home, having survived the horrors of war, only to have their own bodies betray them decades later? Here’s some of what’s been done to fight aging in May. LEAF News