Category: News
What is Metformin? A Summary of N,N-dimethylbiguanide
November 17, 2021
We take a look at this diabetic drug that some researchers think may slow down aging. What is metformin? Metformin is a prescription drug and is available as a tablet
Nicotinamide Alleviates Skin Aging in Cellular Study
November 16, 2021
A group of researchers successfully alleviated aspects of skin aging by treating skin cells with the NAD precursor nicotinamide [1]. Hard work done by skin leads to its burnout Skin
Using Young Stem Cells to Restore Old Stem Cells
November 15, 2021
In a study published in Aging, researchers have found that younger hematopoietic cells can restore older hematopoietic cells through microvesicles, which are facilitators of intercellular communication. Placing young and old
Investigation of Dr. Aubrey de Grey Concludes
November 12, 2021
In August of this year, we reported that Dr. Aubrey de Grey, the then-Chief-Science Officer of the SENS Research Foundation (SRF), was the subject of sexual harassment allegations raised by
Plasma Exchange Alleviates Alzheimer’s in a Human Trial
November 12, 2021
New results from the AMBAR trial show that plasma exchange leads to statistically significant functional and cognitive improvements in patients with mild to moderate Alzheimer’s [1]. As our readers surely
DNA Damage, Inflammation, and the Stem Cell Microenvironment
November 11, 2021
A review published in Frontiers in Cell and Developmental Biology has explained how DNA damage and its accompanying immune response lead to changes in the microenvironment of stem cells, causing
New NF-κB Targeting Drug Improves Healthspan in Mice
November 10, 2021
New mouse data published in the latest issue of Aging Cell highlights the aging benefits of a novel NF-κB-based drug. NF-κB in aging and disease NF-κB is a transcription factor
“Ageless” by Andrew Steele: A Perfect Pop-Sci Book on Aging?
November 9, 2021
People have looked for ways to extend their lives since… well, forever. The oldest known myth on earth, Gilgamesh, is about a Sumerian king embarking on a quest for immortality
Blueberry Extract Alleviates Alzheimer’s in Mice
November 9, 2021
A group of researchers has confirmed the neuroprotective effect of blueberry extract and identified a possible mechanism of action that might facilitate drug development [1]. The delicious cure? Blueberries have
How Telomerase Reverse Transcriptase Protects the Heart
November 8, 2021
Research published in Circulation has shown that mitochondrial, but not nuclear, telomerase reverse transcriptase (TERT) protects against damage caused by heart attacks in a murine model. A non-canonical role While
Twin Drug Combo Convinces Cancer Cells To Eat Themselves
November 5, 2021
In an important proof-of-concept study, scientists have successfully employed a ferroptosis activator and an mTOR inhibitor against bladder cancer cells [1]. Ferroptosis – “the iron death” Ferroptosis is a distinct
How Uncontrolled Diabetes Is Linked to Cognitive Impairment
November 4, 2021
A team of Spanish researchers has examined how glucose imbalance leads to neurological disorders through the failure of adipocytokines. What are adipocytokines? These compounds’ name seems a bit concerning: “adipo-”
Multi-omics Identifies Longevity Genes, Therapeutic Targets
November 3, 2021
The latest research in Aging Cell has brought to light new insights into the biology of aging and associated therapeutic candidates. What is multi-omics? “-omics” refers to branches of molecular
Lorna Harries: “We’re Looking to Reverse Senescence”
November 3, 2021
Lorna Harries is a Professor of Molecular Genetics at the University of Exeter Medical School. She is also the CSO and R&D lead at SENISCA Ltd. Like many other companies,
Removing Senescent Cancer Cells With Peptides
November 2, 2021
A study published in EBioMedicine has shown how a peptide targets and kills senescent cancer cells, potentially paving the way for a new class of interventions. Why kill senescent cancer
What is Metformin? A Summary of N,N-dimethylbiguanide
November 17, 2021
We take a look at this diabetic drug that some researchers think may slow down aging. What is metformin? Metformin is a prescription drug and is available as a tablet or an oral solution. It is a commonly used first-line medication for the treatment of type
Nicotinamide Alleviates Skin Aging in Cellular Study
November 16, 2021
A group of researchers successfully alleviated aspects of skin aging by treating skin cells with the NAD precursor nicotinamide [1]. Hard work done by skin leads to its burnout Skin aging might not be lethal, apart from the increased risk of skin cancer, but it’s surely
Using Young Stem Cells to Restore Old Stem Cells
November 15, 2021
In a study published in Aging, researchers have found that younger hematopoietic cells can restore older hematopoietic cells through microvesicles, which are facilitators of intercellular communication. Placing young and old together To begin their experiment, the researchers placed equal amounts of young and old cells in
Investigation of Dr. Aubrey de Grey Concludes
November 12, 2021
In August of this year, we reported that Dr. Aubrey de Grey, the then-Chief-Science Officer of the SENS Research Foundation (SRF), was the subject of sexual harassment allegations raised by Laura Deming of Longevity Fund and Celine Halioua of Loyal, a dog longevity startup, via their
Plasma Exchange Alleviates Alzheimer’s in a Human Trial
November 12, 2021
New results from the AMBAR trial show that plasma exchange leads to statistically significant functional and cognitive improvements in patients with mild to moderate Alzheimer’s [1]. As our readers surely know, the world is spending much more resources on fighting the diseases of aging than on
DNA Damage, Inflammation, and the Stem Cell Microenvironment
November 11, 2021
A review published in Frontiers in Cell and Developmental Biology has explained how DNA damage and its accompanying immune response lead to changes in the microenvironment of stem cells, causing a decline in their function. A direct relationship After an introduction, the reviewers begin their discussion
New NF-κB Targeting Drug Improves Healthspan in Mice
November 10, 2021
New mouse data published in the latest issue of Aging Cell highlights the aging benefits of a novel NF-κB-based drug. NF-κB in aging and disease NF-κB is a transcription factor found in nearly all animal cell types. It is activated in response to multiple physiological insults,
“Ageless” by Andrew Steele: A Perfect Pop-Sci Book on Aging?
November 9, 2021
People have looked for ways to extend their lives since… well, forever. The oldest known myth on earth, Gilgamesh, is about a Sumerian king embarking on a quest for immortality after his friend’s death. Alchemists were looking for magic death-defying substances, adventurers searched for the legendary
Blueberry Extract Alleviates Alzheimer’s in Mice
November 9, 2021
A group of researchers has confirmed the neuroprotective effect of blueberry extract and identified a possible mechanism of action that might facilitate drug development [1]. The delicious cure? Blueberries have long been on the list of “superfoods” that supposedly protect our health and maybe help us
How Telomerase Reverse Transcriptase Protects the Heart
November 8, 2021
Research published in Circulation has shown that mitochondrial, but not nuclear, telomerase reverse transcriptase (TERT) protects against damage caused by heart attacks in a murine model. A non-canonical role While TERT’s name comes from its main function, the protection of telomere length in the cellular nucleus,
Twin Drug Combo Convinces Cancer Cells To Eat Themselves
November 5, 2021
In an important proof-of-concept study, scientists have successfully employed a ferroptosis activator and an mTOR inhibitor against bladder cancer cells [1]. Ferroptosis – “the iron death” Ferroptosis is a distinct type of cell death that gets less attention and is less well understood than the more
How Uncontrolled Diabetes Is Linked to Cognitive Impairment
November 4, 2021
A team of Spanish researchers has examined how glucose imbalance leads to neurological disorders through the failure of adipocytokines. What are adipocytokines? These compounds’ name seems a bit concerning: “adipo-” refers to fat, and a cytokine is a cellular signal most commonly known for being part
Multi-omics Identifies Longevity Genes, Therapeutic Targets
November 3, 2021
The latest research in Aging Cell has brought to light new insights into the biology of aging and associated therapeutic candidates. What is multi-omics? “-omics” refers to branches of molecular biology that attempt to characterize and/or quantify their components in totality, often using recently developed big
Lorna Harries: “We’re Looking to Reverse Senescence”
November 3, 2021
Lorna Harries is a Professor of Molecular Genetics at the University of Exeter Medical School. She is also the CSO and R&D lead at SENISCA Ltd. Like many other companies, and as evidenced by the name, SENISCA targets senescent cells, albeit using an unusual mRNA-based approach.
Removing Senescent Cancer Cells With Peptides
November 2, 2021
A study published in EBioMedicine has shown how a peptide targets and kills senescent cancer cells, potentially paving the way for a new class of interventions. Why kill senescent cancer cells? Senescence and cancer are usually considered to be completely opposed, and in many ways, they