Category: Biology of Aging
Ginkgolide B Improves Healthspan and Lifespan in Female Mice
March 5, 2025
The authors of a recent study describe Ginkgolide B, a compound with senotherapeutic potential that improved muscle health, metabolism, frailty, inflammation, and senescence metrics and increased lifespan in female mice
Genes Affect Aging and Mortality Less Than Extrinsic Factors
March 4, 2025
A massive study from the University of Oxford has evaluated the relative impact of genetic and non-genetic factors on aging, mortality, and disease prevalence. A deeper dive The question of
A Protein That Controls Senescent Cell Structure
February 28, 2025
Researchers publishing in Cellular Signaling have explained how the protein AP2A1 affects stress fibers that change with cellular senescence. Stress fibers Stress fibers naturally hold cells into their proper shape.
Effects of Estradiol and Progesterone on Knee Osteoarthritis
February 26, 2025
Recent research has addressed menopause-related molecular processes that impact the high prevalence of knee osteoarthritis in post-menopausal women. Restoration of female sex hormones in a post-menopausal mouse model improved joint
Young Plasma Decreases Inflammation After Surgery in Trial
February 20, 2025
In the Journal of Translational Medicine, researchers have published the results of a randomized, controlled clinical trial demonstrating that plasma proteins from young donors have beneficial effects against inflammation in
Repurposing Drugs to Lower Dementia Risk
February 19, 2025
The authors of a recent review analyzed the results of 14 studies that included 139 million people to identify patterns that connect dementia risk to commonly used medications [1]. Finding
A Key Protein for Tendon Health
February 17, 2025
Researchers publishing in Matrix Biology Plus have discovered that cochlin, a protein that decreases with age, is vital for the health of tendons. Tendons require a healthy extracellular matrix Previous
A Potential New Target for Normal Brain Aging
February 13, 2025
Yesterday in Aging Cell, researchers published their findings that using gene therapy to overexpress a synaptic promoter increases cognitive ability in ordinary, middle-aged mice. Hevin vs. SPARC Astrocytes are general-purpose
Probiotics Slow Down Alzheimer’s Disease in Mice
February 12, 2025
A new study dives into a human-derived probiotic cocktail meant to protect against Alzheimer’s disease. The treatment improves gut health and reduces inflammation in mice [1]. The earlier, the better
Mitochondrial Damage May Drive Type 2 Diabetes
February 11, 2025
A new study suggests that damaged mitochondria activate the integrated stress response, which causes pancreatic β-cells, as well as liver and fat cells, to lose their identity and malfunction [1].
Creating a Functional Pancreas From Human Cells
February 10, 2025
In Cell Reports Medicine, researchers have described how they created a fully functional pancreas made from human cells and found it to work in mice. A new era of organ
Some Stem Cells Remain Youthful With Age
February 6, 2025
A team of scientists has discovered that some hematopoietic stem cells (HSCs) lose their ability to differentiate into useful somatic cells and that removing those bad HSCs is beneficial. Blood
How the Yamanaka Factors Affect Female Reproduction in Rats
February 5, 2025
The authors of a recent study reported that OSKM/Yamanaka factor gene therapy in rats results in higher fertility at an older age compared to controls and allows older rats to
New Nanoparticles for Treating Arthritis
February 3, 2025
In the Journal of Nanobiotechnology, researchers have described a new method of delivering a long-lasting treatment into cartilage. A protein that promotes autophagy Previous work has linked expression of the
Artificially Grown Tissue Repairs Heart Failure in Monkeys
January 31, 2025
German scientists have created lab-grown “patches” of heart muscle tissue derived from pluripotent stem cells. Following a success with rhesus monkeys, they have obtained approval for a human trial [1].
Ginkgolide B Improves Healthspan and Lifespan in Female Mice
March 5, 2025
The authors of a recent study describe Ginkgolide B, a compound with senotherapeutic potential that improved muscle health, metabolism, frailty, inflammation, and senescence metrics and increased lifespan in female mice [1]. From East Asia to the clinic Ginkgolide B is a compound that can be extracted
Genes Affect Aging and Mortality Less Than Extrinsic Factors
March 4, 2025
A massive study from the University of Oxford has evaluated the relative impact of genetic and non-genetic factors on aging, mortality, and disease prevalence. A deeper dive The question of how strongly genes affect our longevity has been asked before, and the emerging answer is not
A Protein That Controls Senescent Cell Structure
February 28, 2025
Researchers publishing in Cellular Signaling have explained how the protein AP2A1 affects stress fibers that change with cellular senescence. Stress fibers Stress fibers naturally hold cells into their proper shape. They are made out of the common protein actin and linked together by α-actinin and a
Effects of Estradiol and Progesterone on Knee Osteoarthritis
February 26, 2025
Recent research has addressed menopause-related molecular processes that impact the high prevalence of knee osteoarthritis in post-menopausal women. Restoration of female sex hormones in a post-menopausal mouse model improved joint health [1]. A centuries-old observation The authors start the article with a quote from the English
Young Plasma Decreases Inflammation After Surgery in Trial
February 20, 2025
In the Journal of Translational Medicine, researchers have published the results of a randomized, controlled clinical trial demonstrating that plasma proteins from young donors have beneficial effects against inflammation in a surgical context. From parabiosis experiments to the clinic It has been documented for two decades
Repurposing Drugs to Lower Dementia Risk
February 19, 2025
The authors of a recent review analyzed the results of 14 studies that included 139 million people to identify patterns that connect dementia risk to commonly used medications [1]. Finding a new purpose Despite its prevalence in the elderly population, there is a lack of effective
A Key Protein for Tendon Health
February 17, 2025
Researchers publishing in Matrix Biology Plus have discovered that cochlin, a protein that decreases with age, is vital for the health of tendons. Tendons require a healthy extracellular matrix Previous work has found that tendon tissues, which link muscle to bone, require a healthy extracellular matrix
A Potential New Target for Normal Brain Aging
February 13, 2025
Yesterday in Aging Cell, researchers published their findings that using gene therapy to overexpress a synaptic promoter increases cognitive ability in ordinary, middle-aged mice. Hevin vs. SPARC Astrocytes are general-purpose helper cells of the brain, and one of their tasks is to maintain synapse structure [1].
Probiotics Slow Down Alzheimer’s Disease in Mice
February 12, 2025
A new study dives into a human-derived probiotic cocktail meant to protect against Alzheimer’s disease. The treatment improves gut health and reduces inflammation in mice [1]. The earlier, the better Early interventions to prevent or delay Alzheimer’s disease might be a more feasible approach than reversing
Mitochondrial Damage May Drive Type 2 Diabetes
February 11, 2025
A new study suggests that damaged mitochondria activate the integrated stress response, which causes pancreatic β-cells, as well as liver and fat cells, to lose their identity and malfunction [1]. Blocking this response had benefits in mouse models. The mitochondria-diabetes connection Like with many diseases, the
Creating a Functional Pancreas From Human Cells
February 10, 2025
In Cell Reports Medicine, researchers have described how they created a fully functional pancreas made from human cells and found it to work in mice. A new era of organ replacement In their introduction, the researchers discuss the well-known problems with insulin injections to treat Type
Some Stem Cells Remain Youthful With Age
February 6, 2025
A team of scientists has discovered that some hematopoietic stem cells (HSCs) lose their ability to differentiate into useful somatic cells and that removing those bad HSCs is beneficial. Blood creation diminishes with age Hematopoiesis refers to the production of blood cells, both white and red.
How the Yamanaka Factors Affect Female Reproduction in Rats
February 5, 2025
The authors of a recent study reported that OSKM/Yamanaka factor gene therapy in rats results in higher fertility at an older age compared to controls and allows older rats to have regular cycles [1]. Rejuvenating Yamanaka factors Multiple studies have suggested that gene therapy that uses
New Nanoparticles for Treating Arthritis
February 3, 2025
In the Journal of Nanobiotechnology, researchers have described a new method of delivering a long-lasting treatment into cartilage. A protein that promotes autophagy Previous work has linked expression of the FGF18 protein with healthy cartilage and joints [1]. Problems with the gene responsible for FGF18 lead
Artificially Grown Tissue Repairs Heart Failure in Monkeys
January 31, 2025
German scientists have created lab-grown “patches” of heart muscle tissue derived from pluripotent stem cells. Following a success with rhesus monkeys, they have obtained approval for a human trial [1]. Wear and tear As one of the most hard-working tissues in the body, the heart muscle