Category: Biology of Aging
Skin Aging and Cellular Mobility at the Protein Level
August 29, 2024
In Aging, researchers have described how the changing production of skin cells’ proteins is a core part of their age-related decline. Understanding why skin cells lose their function In healthy
NNMT Inhibitor Improves Muscle Function in Aged Mice
August 28, 2024
A recent paper has reported on improving muscle function in aged mice through combined treatment of exercise and the inhibition of NNMT, an enzyme involved in NAD+ metabolism [1]. Age-related
Why Bone Destruction Is Accelerated with Aging
August 26, 2024
Researchers have described a relationship between the NAD+ regulator CD38, mitochondrial function, and the gradual destruction of bone in Aging Cell. Inflammation up, bone mass down It is well known
Manuka Honey Effective Against Breast Cancer in Mice
August 23, 2024
UCLA scientists have shown that Manuka, an exclusive honey variety, can quench estrogen receptor-positive breast cancer in vitro and in vivo [1]. Honey, kill that cancer Breast cancer remains the
A Phase 2 Clinical Trial for Hair Loss
August 22, 2024
Los Angeles-based Pelage Pharmaceuticals has just announced a Phase 2a clinical trial for the treatment of androgenetic alopecia, also known as pattern baldness. It is thought that up to 50%
Fighting Inflammation May Cause More Senescence
August 19, 2024
A researcher publishing in Biogerontology has reviewed the literature on the relationship between cellular senescence and the immune system, finding that dwindling immune surveillance allows senescent cells to accumulate. The
Inflammation May Drive Fat Distribution in Older People
August 15, 2024
A new study published in Aging Cell has detailed what happens to individual fat cells in white adipose tissue (WAT) as they age. When fat is more than just fat
A Botanical Extract Extends Lifespan and Healthspan in Mice
August 14, 2024
According to a new study, a polyphenol-rich natural extract positively impacts lifespan, healthspan, and cellular senescence. These results were observed in both cell culture and a mouse model [1]. From
NMN Increases Lifespan in Female Mice
August 13, 2024
A new preprint from David Sinclair’s lab has discovered that NMN supplementation started in midlife increases median and maximal lifespan in female mice and boosts healthspan in males [1]. NAD
A Ketosis-Related Compound Alleviates Arthritis in Rats
August 12, 2024
In Aging Cell, researchers have published details on the pathway by which a compound commonly found in ketone bodies ameliorates osteoarthritis in a rat model. Chondrocytes are crucial in arthritis
Immune Peptide Might Keep White Blood Cells Contained
August 8, 2024
In npj Aging, researchers have described how immune cell infiltration in inflammaging can be reduced with an immune-related peptide in a mouse model. Immune cell infiltration In a previous paper,
Fecal Microbiota Transplants Reduce Vascular Aging in Mice
August 7, 2024
Fecal microbiota transplantation from young mice to older mice improved multiple metabolic parameters and some hallmarks of aging, such as inflammation and telomere shortening [1]. Bringing back the balance Dysbiosis,
Hyperbaric Oxygen Therapy Increases Fitness in Elderly
August 6, 2024
In a new study, a 12-week protocol of hyperbaric oxygen therapy (HBOT) resulted in marked increases in aerobic capacity and cardiac blood flow [1]. Building pressure HBOT involves placing patients
New Epigenetic Clock Built on Lurking DNA Fragments
August 5, 2024
In Aging Cell, a team of researchers has announced Retroelement-Age, a novel clock that focuses on the expression of buried pieces of DNA that are normally suppressed. Corrupted but unexpressed
Rapamycin + Trametinib Increase Mouse Lifespan by up to 35%
August 1, 2024
Combining rapamycin and trametinib seemed to have a cumulative effect in both sexes but mostly in females [1]. These results are probably due to a reduction in both cancer and
Skin Aging and Cellular Mobility at the Protein Level
August 29, 2024
In Aging, researchers have described how the changing production of skin cells’ proteins is a core part of their age-related decline. Understanding why skin cells lose their function In healthy skin, dermal fibroblasts produce the proteins needed to maintain the extracellular matrix (ECM), the network of
NNMT Inhibitor Improves Muscle Function in Aged Mice
August 28, 2024
A recent paper has reported on improving muscle function in aged mice through combined treatment of exercise and the inhibition of NNMT, an enzyme involved in NAD+ metabolism [1]. Age-related muscle loss Muscle loss is a common problem in the aging population. Studies estimate that “after
Why Bone Destruction Is Accelerated with Aging
August 26, 2024
Researchers have described a relationship between the NAD+ regulator CD38, mitochondrial function, and the gradual destruction of bone in Aging Cell. Inflammation up, bone mass down It is well known that CD38, an enzyme that takes away NAD+, increases with age. The gradual depletion of this
Manuka Honey Effective Against Breast Cancer in Mice
August 23, 2024
UCLA scientists have shown that Manuka, an exclusive honey variety, can quench estrogen receptor-positive breast cancer in vitro and in vivo [1]. Honey, kill that cancer Breast cancer remains the deadliest type of cancer in women, claiming more than 40 thousand victims a year in the
A Phase 2 Clinical Trial for Hair Loss
August 22, 2024
Los Angeles-based Pelage Pharmaceuticals has just announced a Phase 2a clinical trial for the treatment of androgenetic alopecia, also known as pattern baldness. It is thought that up to 50% of men experience hair loss as a result of pattern baldness by age 50. In this
Fighting Inflammation May Cause More Senescence
August 19, 2024
A researcher publishing in Biogerontology has reviewed the literature on the relationship between cellular senescence and the immune system, finding that dwindling immune surveillance allows senescent cells to accumulate. The immune system needs to be deadly On the cellular level, the bodies of vertebrates are brutal
Inflammation May Drive Fat Distribution in Older People
August 15, 2024
A new study published in Aging Cell has detailed what happens to individual fat cells in white adipose tissue (WAT) as they age. When fat is more than just fat Previous research has described WAT as an organ in its own right, functioning not only as
A Botanical Extract Extends Lifespan and Healthspan in Mice
August 14, 2024
According to a new study, a polyphenol-rich natural extract positively impacts lifespan, healthspan, and cellular senescence. These results were observed in both cell culture and a mouse model [1]. From folk medicine to modern science Traditional and folk medicines offer many botanical extracts that can be
NMN Increases Lifespan in Female Mice
August 13, 2024
A new preprint from David Sinclair’s lab has discovered that NMN supplementation started in midlife increases median and maximal lifespan in female mice and boosts healthspan in males [1]. NAD and aging Nicotinamide adenine dinucleotide (NAD) is a ubiquitous metabolite that performs several crucial roles. NAD’s
A Ketosis-Related Compound Alleviates Arthritis in Rats
August 12, 2024
In Aging Cell, researchers have published details on the pathway by which a compound commonly found in ketone bodies ameliorates osteoarthritis in a rat model. Chondrocytes are crucial in arthritis The cartilage holding joints together is built and maintained by chondrocytes, which synthesize such necessary proteins
Immune Peptide Might Keep White Blood Cells Contained
August 8, 2024
In npj Aging, researchers have described how immune cell infiltration in inflammaging can be reduced with an immune-related peptide in a mouse model. Immune cell infiltration In a previous paper, these researchers have reported that aging affects the movement of white blood cells (leukocytes) in a
Fecal Microbiota Transplants Reduce Vascular Aging in Mice
August 7, 2024
Fecal microbiota transplantation from young mice to older mice improved multiple metabolic parameters and some hallmarks of aging, such as inflammation and telomere shortening [1]. Bringing back the balance Dysbiosis, an imbalance in the gut microbiome, is a newly recognized hallmark of aging [2]. Dysbiosis elevates
Hyperbaric Oxygen Therapy Increases Fitness in Elderly
August 6, 2024
In a new study, a 12-week protocol of hyperbaric oxygen therapy (HBOT) resulted in marked increases in aerobic capacity and cardiac blood flow [1]. Building pressure HBOT involves placing patients in a tightly sealed chamber where they breathe pure oxygen under higher-than-normal atmospheric pressure. This treatment
New Epigenetic Clock Built on Lurking DNA Fragments
August 5, 2024
In Aging Cell, a team of researchers has announced Retroelement-Age, a novel clock that focuses on the expression of buried pieces of DNA that are normally suppressed. Corrupted but unexpressed The natural human genome has a large number of artifacts left over from ancient viral infections
Rapamycin + Trametinib Increase Mouse Lifespan by up to 35%
August 1, 2024
Combining rapamycin and trametinib seemed to have a cumulative effect in both sexes but mostly in females [1]. These results are probably due to a reduction in both cancer and inflammation. A winning combo The idea that combination treatments are the future of life extension is