Category: Biology of Aging
Looking for Safety in Epigenetic Rejuvenation
March 7, 2024
In Nature Communications, Ali Yücel and Vadim Gladyshev have published a review of the current state of the art in partial cellular reprogramming, detailing what this technology does and how
Intermittent Rapamycin Lessens Negative Effects in Mice
March 6, 2024
A recent Molecular Metabolism paper dives into the differences between intermittent and chronic rapamycin treatment and its differential impact on male and female mice [1]. The dark side of rapamycin
Decreasing Autophagy Might Reverse Ovarian Aging
March 5, 2024
Experimenting in vitro and in mice, scientists have found that ovarian aging is linked to increased autophagy and apoptosis in granulosa cells and that it can be reversed by an
Using Ultrasound to Assist Gene Therapy
March 4, 2024
A new publication in iScience has described a novel way in which heart tissue can be encouraged to accept a gene therapy by using ultrasound to create cavitation bubbles. A
Niacin (Vitamin B3) Linked to Cardiovascular Risk
February 29, 2024
A new study shows that niacin, a popular food fortifier, supplement, and NAD precursor, might increase the risk of major adverse cardiovascular events by as much as twofold [1]. The
Higher Abdominal Fat Associated with Cognitive Decline
February 28, 2024
A group of Japanese researchers has published a paper reporting an association between higher abdominal fat levels and cognitive decline [1]. Abdominal fat and brain connection Aging is often linked
Physically Fit Older People Have Better Visual Processing
February 27, 2024
Publishing a study in GeroScience featuring people over 80 years old, researchers have described a link between physical fitness and maintenance of specific brain functions. Executive functions This paper begins
Epigenetic Clocks Help Predict Health Outcomes
February 26, 2024
Researchers publishing in PNAS have found that well-known epigenetic clocks are valuable in predicting health outcomes, including mortality, in human beings. The usefulness of clocks This paper begins with a
Meaningful Improvements in Human Trial For Sarcopenia
February 22, 2024
Rejuvenate Biomed has recently concluded a clinical trial for sarcopenia. The results have shown “meaningful improvements in muscle strength, function and fatigue resistance”. What is sarcopenia? Sarcopenia is an age-related
A Nanoparticle Reduces Brain Inflammation in Mice
February 22, 2024
A recent preprint paper from researchers at Sachi Bio has described how this company’s technology can be used to alleviate brain inflammation in a mouse model. The problem of tau
Rejuvenate Bio Develops Gene Therapy for Dog Arthritis
February 20, 2024
Rejuvenate Bio has announced a partnership with a leading animal health company to develop a gene therapy for canine osteoarthritis. The identity of the partnering global company is as yet
Connecting Gut Metabolism to Grip Strength
February 19, 2024
In Aging, a team of researchers has outlined a possible relationship between low grip strength and compounds in the gut microbiome. The gut-muscle axis As these researchers note, previous work
Solving Atherosclerosis: The Small but Mighty Molecule
February 19, 2024
Cyclarity Therapeutics is developing an affordable, plaque-busting small molecule that may be the cure for the world’s number one killer: cardiovascular disease. With human trials planned for this year, we
The Latest in Rapamycin Research on Humans
February 18, 2024
Reviewers have gone through the latest updates on studies featuring rapamycin and its derivatives in The Lancet Healthy Longevity. Testing a well-known longevity promoter Not many compounds actually extend life
New Drug Shows Promise Against Glioblastoma
February 16, 2024
Scientists have discovered a small molecule that effectively kills glioblastoma, a highly aggressive and untreatable brain cancer, in cellular cultures [1]. When acidic means deadly Despite scientists’ best efforts, some
Looking for Safety in Epigenetic Rejuvenation
March 7, 2024
In Nature Communications, Ali Yücel and Vadim Gladyshev have published a review of the current state of the art in partial cellular reprogramming, detailing what this technology does and how it might be used safely. Affecting methylation directly This paper begins by treading familiar ground on
Intermittent Rapamycin Lessens Negative Effects in Mice
March 6, 2024
A recent Molecular Metabolism paper dives into the differences between intermittent and chronic rapamycin treatment and its differential impact on male and female mice [1]. The dark side of rapamycin Rapamycin doesn’t need much introduction in the lifespan extension community. This mTOR inhibitor has been shown
Decreasing Autophagy Might Reverse Ovarian Aging
March 5, 2024
Experimenting in vitro and in mice, scientists have found that ovarian aging is linked to increased autophagy and apoptosis in granulosa cells and that it can be reversed by an estrogen receptor inhibitor [1]. When ovaries get tired Female reproductive aging is an intriguing phenomenon that
Using Ultrasound to Assist Gene Therapy
March 4, 2024
A new publication in iScience has described a novel way in which heart tissue can be encouraged to accept a gene therapy by using ultrasound to create cavitation bubbles. A little-known target and a new delivery vector This paper begins with a discussion of S-adenosylhomocysteine (SAH),
Niacin (Vitamin B3) Linked to Cardiovascular Risk
February 29, 2024
A new study shows that niacin, a popular food fortifier, supplement, and NAD precursor, might increase the risk of major adverse cardiovascular events by as much as twofold [1]. The dark side of niacin? Vitamins are good for you, but caveats apply. Too much of some
Higher Abdominal Fat Associated with Cognitive Decline
February 28, 2024
A group of Japanese researchers has published a paper reporting an association between higher abdominal fat levels and cognitive decline [1]. Abdominal fat and brain connection Aging is often linked to many comorbidities, one of which is dementia, and developing drugs to treat this condition is
Physically Fit Older People Have Better Visual Processing
February 27, 2024
Publishing a study in GeroScience featuring people over 80 years old, researchers have described a link between physical fitness and maintenance of specific brain functions. Executive functions This paper begins with a description of executive functions, the basic abilities involved in performing the fundamental goal-oriented behaviors
Epigenetic Clocks Help Predict Health Outcomes
February 26, 2024
Researchers publishing in PNAS have found that well-known epigenetic clocks are valuable in predicting health outcomes, including mortality, in human beings. The usefulness of clocks This paper begins with a discussion of epigenetic clocks, most notably the later-generation clocks, such as PhenoAge, DunedinPACE, and the strong
Meaningful Improvements in Human Trial For Sarcopenia
February 22, 2024
Rejuvenate Biomed has recently concluded a clinical trial for sarcopenia. The results have shown “meaningful improvements in muscle strength, function and fatigue resistance”. What is sarcopenia? Sarcopenia is an age-related progressive loss of muscle mass and strength that affects many older adults. This decline in muscle
A Nanoparticle Reduces Brain Inflammation in Mice
February 22, 2024
A recent preprint paper from researchers at Sachi Bio has described how this company’s technology can be used to alleviate brain inflammation in a mouse model. The problem of tau Along with the infamous amyloid beta, tau is well-known as a pathological factor in both Alzheimer’s
Rejuvenate Bio Develops Gene Therapy for Dog Arthritis
February 20, 2024
Rejuvenate Bio has announced a partnership with a leading animal health company to develop a gene therapy for canine osteoarthritis. The identity of the partnering global company is as yet unknown. This San Diego-based biotech was co-founded in 2017 by Professor George Church of Harvard Medical
Connecting Gut Metabolism to Grip Strength
February 19, 2024
In Aging, a team of researchers has outlined a possible relationship between low grip strength and compounds in the gut microbiome. The gut-muscle axis As these researchers note, previous work has described many of the various ways in which metabolism is related to age-related muscle dysfunction,
Solving Atherosclerosis: The Small but Mighty Molecule
February 19, 2024
Cyclarity Therapeutics is developing an affordable, plaque-busting small molecule that may be the cure for the world’s number one killer: cardiovascular disease. With human trials planned for this year, we decided that it was time to catch up with Cyclarity and its CEO of Scientific Affairs,
The Latest in Rapamycin Research on Humans
February 18, 2024
Reviewers have gone through the latest updates on studies featuring rapamycin and its derivatives in The Lancet Healthy Longevity. Testing a well-known longevity promoter Not many compounds actually extend life in healthy animals, but rapamycin is indeed one of them. These researchers report that its mechanism
New Drug Shows Promise Against Glioblastoma
February 16, 2024
Scientists have discovered a small molecule that effectively kills glioblastoma, a highly aggressive and untreatable brain cancer, in cellular cultures [1]. When acidic means deadly Despite scientists’ best efforts, some types of cancer remain almost as deadly as ever. This includes the dreaded glioblastoma, a type