Category: Biology of Aging
Debunking Myths About Work Stress and Age Acceleration
February 10, 2022
A study published in Aging that studied the Northern Finland Birth Cohort of 1966 has found some interesting and counterintuitive results regarding work stress and accelerated epigenetic aging. Work stress
Researcher Offers A Critique of Geroscience
February 10, 2022
Eric Le Bourg has published a thought-provoking paper in Biogerontology that offers a critique of geroscience [1]. Geroscience, we need to talk… When people discuss the prospects of targeting the
Irina Conboy on Heterochronic Plasma at EARD2021
February 9, 2022
At Ending Age-Related Diseases 2021, Irina Conboy discussed the effects of plasma dilution and heterochronic plasma exchange and their relationship to epigenetic alterations. Script Thank you for inviting me again,
A Polyphenol-Rich Diet Reduces Age-Related Cognitive Decline
February 9, 2022
A preprint study originating from the DIRECT PLUS trial was recently released from the American Journal of Clinical Nutrition [1]. This study has been accepted into the journal but has
Senolytics for Cardiac Regeneration in Diabetics
February 9, 2022
The latest research published in Diabetes has implicated senescent cardiac stem cells as the link between diabetes and cardiovascular disease [1]. Why does diabetes increase the risk of cardiovascular disease?
Longevity Allele Slows Immune and Cardiovascular Aging
February 8, 2022
In a new study, mice transduced with a longevity-associated variant (LAV) of the BPIFB4 gene showed less immunosenescence and healthier vasculature [1]. The importance of having good genes Longevity-associated alleles
Mapping the Gene Expression of Senescent Brain Cells
February 7, 2022
As explained in a paper published in GeroScience, researchers have used spatial transcriptomic analysis to show the inflammatory nodes that are caused by brain cells undergoing senescence. What is spatial
Effective New Method of Cellular Reprogramming Proposed
February 4, 2022
Scientists have proposed a novel method of cellular reprogramming that is more predictable and effective than traditional methods [1]. Geroscience’s Holy Grail Cellular reprogramming is a hot topic in geroscience
Naked Mole Rats Age, but Not Like Other Mammals
February 3, 2022
A research paper published in Nature by Dr. Vadim Gladyshev and his team has investigated the epigenetic aging of the naked mole rat, an animal whose mortality rate does not
Higher Diet Quality Is Linked to Reduced Epigenetic Aging
February 2, 2022
A study published in the American Journal of Clinical Nutrition examined the relationship between diet quality and epigenetic aging clocks [1]. This study used data from the Framingham Heart Study
Brain Cell Types Respond Differently to Aging Interventions
February 2, 2022
A new preprint on bioRxiv shows how researchers have developed transcriptomic, cell type specific aging clocks from the regenerative zones of mouse brains [1]. Measuring age at the level of
Senolytic Navitoclax Rescues Neurogenesis and Memory in Mice
February 1, 2022
Scientists have shown that clearing senescent neural precursor cells with the senolytic drug navitoclax reverses the age-related decline in neurogenesis and improves spatial memory in mice [1]. Not to be
Targeting Metabolism To Slow Down Aging
January 31, 2022
Publishing in Aging, a group of Korean researchers has discovered a compound that affects the way our mitochondria process energy, ameliorating cellular senescence. A deep dive into biochemistry To begin
A New Startup Is Going After Rogue Cells
January 28, 2022
In a blog post, the founder and CEO of Arda Therapeutics, Adam Freund, explained his company’s intriguing strategy along with why it is imperative to counter aging. From Calico to
Senolytics Restore Cognitive Ability in Aged Rats
January 27, 2022
Polish researchers publishing in Aging have discovered that the well-known senolytic combination of dasatinib and quercetin improves the cognitive capabilities of older rats. Understanding neuroplasticity While new neurons can be
Debunking Myths About Work Stress and Age Acceleration
February 10, 2022
A study published in Aging that studied the Northern Finland Birth Cohort of 1966 has found some interesting and counterintuitive results regarding work stress and accelerated epigenetic aging. Work stress is widely associated with premature death It is common folk wisdom that too much stress leads
Researcher Offers A Critique of Geroscience
February 10, 2022
Eric Le Bourg has published a thought-provoking paper in Biogerontology that offers a critique of geroscience [1]. Geroscience, we need to talk… When people discuss the prospects of targeting the aging processes to prevent, halt, or even reverse age-related diseases, their beliefs often fall into two
Irina Conboy on Heterochronic Plasma at EARD2021
February 9, 2022
At Ending Age-Related Diseases 2021, Irina Conboy discussed the effects of plasma dilution and heterochronic plasma exchange and their relationship to epigenetic alterations. Script Thank you for inviting me again, it’s much appreciated. This is an excellent conference series. I will start by telling you that
A Polyphenol-Rich Diet Reduces Age-Related Cognitive Decline
February 9, 2022
A preprint study originating from the DIRECT PLUS trial was recently released from the American Journal of Clinical Nutrition [1]. This study has been accepted into the journal but has not yet been peer reviewed. Duckweed for health This study focused on a plant called Mankai,
Senolytics for Cardiac Regeneration in Diabetics
February 9, 2022
The latest research published in Diabetes has implicated senescent cardiac stem cells as the link between diabetes and cardiovascular disease [1]. Why does diabetes increase the risk of cardiovascular disease? Type 2 diabetes mellitus is closely related to aging. Aging is a major risk factor for
Longevity Allele Slows Immune and Cardiovascular Aging
February 8, 2022
In a new study, mice transduced with a longevity-associated variant (LAV) of the BPIFB4 gene showed less immunosenescence and healthier vasculature [1]. The importance of having good genes Longevity-associated alleles prove that aging does not affect everyone equally. On average, centenarians and supercentenarians are more protected
Mapping the Gene Expression of Senescent Brain Cells
February 7, 2022
As explained in a paper published in GeroScience, researchers have used spatial transcriptomic analysis to show the inflammatory nodes that are caused by brain cells undergoing senescence. What is spatial transcriptomic analysis? Spatial transcription analysis isn’t a full 3D view of an entire brain. Rather, it
Effective New Method of Cellular Reprogramming Proposed
February 4, 2022
Scientists have proposed a novel method of cellular reprogramming that is more predictable and effective than traditional methods [1]. Geroscience’s Holy Grail Cellular reprogramming is a hot topic in geroscience that is being pursued by many academics and companies, including major players such as Google’s Calico
Naked Mole Rats Age, but Not Like Other Mammals
February 3, 2022
A research paper published in Nature by Dr. Vadim Gladyshev and his team has investigated the epigenetic aging of the naked mole rat, an animal whose mortality rate does not appear to increase with age. Do naked mole rats actually age? In this paper, the researchers
Higher Diet Quality Is Linked to Reduced Epigenetic Aging
February 2, 2022
A study published in the American Journal of Clinical Nutrition examined the relationship between diet quality and epigenetic aging clocks [1]. This study used data from the Framingham Heart Study Offspring Cohort. This specific study noted the Dietary Approaches to Stop Hypertension (DASH) scores, which are
Brain Cell Types Respond Differently to Aging Interventions
February 2, 2022
A new preprint on bioRxiv shows how researchers have developed transcriptomic, cell type specific aging clocks from the regenerative zones of mouse brains [1]. Measuring age at the level of a single cell Aging is multi-faceted and difficult to quantify. While chronological age is straightforward, it
Senolytic Navitoclax Rescues Neurogenesis and Memory in Mice
February 1, 2022
Scientists have shown that clearing senescent neural precursor cells with the senolytic drug navitoclax reverses the age-related decline in neurogenesis and improves spatial memory in mice [1]. Not to be replaced The brain is an organ of special concern for geroscientists. It is theorized that we
Targeting Metabolism To Slow Down Aging
January 31, 2022
Publishing in Aging, a group of Korean researchers has discovered a compound that affects the way our mitochondria process energy, ameliorating cellular senescence. A deep dive into biochemistry To begin their paper, the researchers discuss the role of the SASP, the inflammatory cytokine IL-33, and the
A New Startup Is Going After Rogue Cells
January 28, 2022
In a blog post, the founder and CEO of Arda Therapeutics, Adam Freund, explained his company’s intriguing strategy along with why it is imperative to counter aging. From Calico to Arda It’s not every day that the longevity field sees a new player with a fresh
Senolytics Restore Cognitive Ability in Aged Rats
January 27, 2022
Polish researchers publishing in Aging have discovered that the well-known senolytic combination of dasatinib and quercetin improves the cognitive capabilities of older rats. Understanding neuroplasticity While new neurons can be formed in the adult hippocampus through neurogenesis [1], learning and behavioral changes caused by changes in