Category: Biology of Aging
Osteopontin Bone Remodeling May Be Key to Arthritis
January 6, 2022
A study published in Aging has found that osteopontin’s effects on bone remodeling may be at least partially responsible for osteoarthritis. What is osteopontin? Osteopontin is a glycoprotein found in
The Effects of Spermidine on Heart Mitochondria in Mice
January 5, 2022
The latest research published in the Journal of Anatomy found that spermidine alters the morphology of mitochondria in aged mouse heart tissue [1]. Mitochondrial dysfunction in the aging heart Evidence
A Relationship Between Senescence and Respiratory Infections
January 3, 2022
A study published in Aging Cell has shown that senescent cells impact the way that CD4 T cells differentiate into types and that senolytics can restore this differentiation to a
A Link Between the Circadian Rhythm and Aging
December 29, 2021
A new study published in Aging has shown a relationship between the circadian clock and the changes in gene expression with age. Two complex systems and four distinct species This
NMN Slows Ovarian Aging in Mice
December 24, 2021
Scientists have found that long-term supplementation with NMN, an NAD+ precursor, dramatically slows reproductive aging in mice by improving mitochondrial function and alleviating senescence [1]. Reproductive aging affects women relatively
A Potential Vaccine for Senescent Cells
December 23, 2021
The journal Nature has published a letter communication regarding a senolytic vaccination study [1]. These letters are typically research studies that the editor chooses to urgently publish due to the
Happy Holidays from lifespan.io
December 23, 2021
Dear Friends, As we close out the year and continue the holiday season, I want to take this opportunity to thank you for being part of our community at lifespan.io
Senolytics Improve Muscle Regeneration Only in Old Animals
December 22, 2021
A new publication in Aging Cell has found divergent results between the post-injury muscle regeneration of young and old mice treated with senolytics [1]. Senescent cells: Friend or foe for muscle regeneration?
The Effects of Physical Activity on Frailty
December 21, 2021
A new study shows that even low levels of physical activity are very good for your muscles, bones, and joints, but exercising too much can potentially harm you [1]. The
A Vaccine for High Cholesterol Works in Mice
December 20, 2021
Researchers publishing in Cell Reports Medicine have discovered that a vaccine targeting angiopoietin-like protein 3 (ANGPTL3) alleviates dyslipidemia and improves outcomes in obese mice. What is dyslipidemia? Dyslipidemia is marked
NewLimit: A New Biotech Working on Epigenetic Aging
December 17, 2021
Two investors, including a co-founder of Coinbase, have announced a new biotech venture that aims to solve aging by studying its epigenetic aspects. New kid on the block Long gone
Old Serum Shown to Kill Brain Stem Cells
December 16, 2021
A study published in Aging and Disease has shown how exposure to old serum causes hippocampal progenitor cells (HPCs), which form new neurons, to die. Drawing and testing serum from
Plant-Based Diet Linked To Reduced Leaky Gut Syndrome
December 15, 2021
The MaPLE trial in Italy investigated whether or not increasing fruits and vegetables decreases leaky gut syndrome [1]. Background This study examines increased intestinal permeability (leaky gut) in adults 60
Epigenetic Clock Shows Association With Cardiovascular Aging
December 15, 2021
A new study published in Mechanisms of Ageing and Development has found correlations between cardiovascular aging and a measure of epigenetic age acceleration [1]. Can epigenetic clocks predict cardiovascular disease?
A Grape seed Extract Slows Aging In Mice
December 14, 2021
Studying grape seed extract, scientists have discovered a new senomorphic compound that enhances chemotherapy and prolongs lifespan and healthspan in mice [1]. Nature’s drugstore Many drugs have come to us
Osteopontin Bone Remodeling May Be Key to Arthritis
January 6, 2022
A study published in Aging has found that osteopontin’s effects on bone remodeling may be at least partially responsible for osteoarthritis. What is osteopontin? Osteopontin is a glycoprotein found in the extracellular matrix of bone tissue. This is a cytokine that is used in intercellular communication,
The Effects of Spermidine on Heart Mitochondria in Mice
January 5, 2022
The latest research published in the Journal of Anatomy found that spermidine alters the morphology of mitochondria in aged mouse heart tissue [1]. Mitochondrial dysfunction in the aging heart Evidence for mitochondrial dysfunction as a driver of aging has been growing in recent years. As we
A Relationship Between Senescence and Respiratory Infections
January 3, 2022
A study published in Aging Cell has shown that senescent cells impact the way that CD4 T cells differentiate into types and that senolytics can restore this differentiation to a more youthful one. Not all T cells are the same CD4 T cells, often known as
A Link Between the Circadian Rhythm and Aging
December 29, 2021
A new study published in Aging has shown a relationship between the circadian clock and the changes in gene expression with age. Two complex systems and four distinct species This study begins with an introduction to two complicated topics. The first is the circadian rhythm, the
NMN Slows Ovarian Aging in Mice
December 24, 2021
Scientists have found that long-term supplementation with NMN, an NAD+ precursor, dramatically slows reproductive aging in mice by improving mitochondrial function and alleviating senescence [1]. Reproductive aging affects women relatively early in life, but like other types of aging, this one has been considered normal until
A Potential Vaccine for Senescent Cells
December 23, 2021
The journal Nature has published a letter communication regarding a senolytic vaccination study [1]. These letters are typically research studies that the editor chooses to urgently publish due to the importance they hold for the other researchers in the field. They may or may not be
Happy Holidays from lifespan.io
December 23, 2021
Dear Friends, As we close out the year and continue the holiday season, I want to take this opportunity to thank you for being part of our community at lifespan.io and helping to bring an end to the diseases of aging. 2021 has been another challenging
Senolytics Improve Muscle Regeneration Only in Old Animals
December 22, 2021
A new publication in Aging Cell has found divergent results between the post-injury muscle regeneration of young and old mice treated with senolytics [1]. Senescent cells: Friend or foe for muscle regeneration? While it may not be obvious from the way senescent cells are often discussed in longevity
The Effects of Physical Activity on Frailty
December 21, 2021
A new study shows that even low levels of physical activity are very good for your muscles, bones, and joints, but exercising too much can potentially harm you [1]. The unholy trinity Sarcopenia, osteoporosis, and osteoarthritis are the trio of age-related diseases that affect, respectively, muscles,
A Vaccine for High Cholesterol Works in Mice
December 20, 2021
Researchers publishing in Cell Reports Medicine have discovered that a vaccine targeting angiopoietin-like protein 3 (ANGPTL3) alleviates dyslipidemia and improves outcomes in obese mice. What is dyslipidemia? Dyslipidemia is marked by having an excess of low-density lipoprotein (LDL) cholesterol, a lack of high-density lipoprotein (HDL) cholesterol,
NewLimit: A New Biotech Working on Epigenetic Aging
December 17, 2021
Two investors, including a co-founder of Coinbase, have announced a new biotech venture that aims to solve aging by studying its epigenetic aspects. New kid on the block Long gone are the times when longevity biotech companies were scarce and poorly funded. Today, barely a week
Old Serum Shown to Kill Brain Stem Cells
December 16, 2021
A study published in Aging and Disease has shown how exposure to old serum causes hippocampal progenitor cells (HPCs), which form new neurons, to die. Drawing and testing serum from living people To begin their study, the researchers examined a middle-aged to old (MATO) cohort ranging
Plant-Based Diet Linked To Reduced Leaky Gut Syndrome
December 15, 2021
The MaPLE trial in Italy investigated whether or not increasing fruits and vegetables decreases leaky gut syndrome [1]. Background This study examines increased intestinal permeability (leaky gut) in adults 60 years and older [1]. Age has been reported to be a risk factor for increased intestinal
Epigenetic Clock Shows Association With Cardiovascular Aging
December 15, 2021
A new study published in Mechanisms of Ageing and Development has found correlations between cardiovascular aging and a measure of epigenetic age acceleration [1]. Can epigenetic clocks predict cardiovascular disease? One way researchers test the validity and usefulness of epigenetic clocks is to compare their outputs
A Grape seed Extract Slows Aging In Mice
December 14, 2021
Studying grape seed extract, scientists have discovered a new senomorphic compound that enhances chemotherapy and prolongs lifespan and healthspan in mice [1]. Nature’s drugstore Many drugs have come to us from the world of plants, including promising geroprotective molecules such as resveratrol. However, identifying specific components