Category: Biology of Aging
Olive Derivative Fights Epigenetic Kidney Aging
December 13, 2021
Researchers publishing in Aging Cell have discovered how and why oleuropein (OLP), a polyphenol derived from olives, ameliorates epigenetic kidney aging. Upregulation and downregulation Like nearly everything in biology, this
Viagra Identified as a Candidate Drug for Alzheimer’s
December 10, 2021
After sifting through 1,600 FDA-approved drugs, scientists have shown that Viagra is significantly correlated with lower Alzheimer’s disease risk [1]. Re-repurposing Viagra? Viagra (sildenafil) is one of the most recognizable
Chinese Licorice Plant Extract Restores Fat Stem Cells
December 9, 2021
Researchers publishing in Aging have reported that licochalcone A (LA), a flavonoid that originates from Chinese licorice, restores human adipose-derived stem cells (hADSCs) in cell culture. Reported positive effects Previous
Demonstration That Cord Blood Improves Progeria
December 9, 2021
A new case report published in the International Journal of Molecular Sciences highlights cardiovascular improvements in a patient with Hutchinson-Gilford progeria treated with umbilical cord blood. A case study using
Hyperbaric Oxygen Causes Transcriptomic Changes
December 8, 2021
Transcriptomic results have been published regarding the Shamir Medical Center longitudinal study on hyperbaric oxygen therapy (HBOT), which was conducted between 2016 and 2020 on 35 healthy adults aged 64
Late-Life Treatment Extends Nematode Lifespan by Two-Fold
December 7, 2021
Scientists have managed to extend the lifespan of C. elegans nematode worms by as much as 135% by blocking an insulin-related pathway very late in life [1]. The long-lived mutants
Building a Universal Immunotherapy for Cancer
December 6, 2021
Researchers publishing in Cell Reports Medicine have described a method of using off-the-shelf, allogeneic immune cells as cancer therapy. Overcoming the hurdles of allogeneic cells Allogeneic cells come from other
Alpha-Ketoglutarate Decreases Biological Age in Human Study
December 3, 2021
A commercially available alpha-ketoglutarate-based supplement has been shown to roll back biological age by 7 years on average in a retrospective human study [1]. Live slower, die later Though metformin and
Narrowed Neck Arteries Lead to Reduced Blood Flow in Eyes
December 2, 2021
Researchers publishing in GeroScience have found that carotid artery stenosis, a consequence of hypertension, is linked to a lack of blood flow in the eyes. A disease that restricts blood
Separating Fact from Fiction in Anti-Aging Diets
December 1, 2021
Dr. Matt Kaeberlein and colleagues recently published a review summarizing anti-aging diets as well as their misconceptions [1]. Caloric restriction, fasting-mimicking diets, and intermittent fasting While fasting diets have been
Bifidobacterium Adolescentis Improves Lifespan in Animals
December 1, 2021
A new publication in Nature Aging has investigated the role of the gut bacteria Bifidobacterium adolescentis in aging and longevity. The aging gut microbiome The gut microbiome, previously thought to
Metformin Alleviates Cognitive Impairment in Long-Term Study
November 30, 2021
Scientists have confirmed yet another positive effect of metformin: its prolonged use by people with diabetes lowers the risk of cognitive impairment and cerebral small vessel disease [1]. A meta-drug?
Mitochondrial Calcium Uptake and Sarcopenia
November 29, 2021
A team of researchers publishing in Cell Death & Disease has found that the age-related decline of mitochondrial calcium uptake family member 3 (MICU3), a regulator of mitochondrial function, is
Rapamycin Prevents Stem Cells from Growing Too Big
November 26, 2021
Researchers have found that hematopoietic stem cells lose function as they grow larger and that rapamycin can alleviate this effect [1]. When cells become obese When it comes to cells, size
p21 Expression Is a Delayed Death Sentence for Cells
November 25, 2021
Researchers publishing in Science have found that the well-known biomarker p21 starts a fatal timer for mouse liver cells. Get better or die As the researchers demonstrate, the cyclin-dependent kinase
Olive Derivative Fights Epigenetic Kidney Aging
December 13, 2021
Researchers publishing in Aging Cell have discovered how and why oleuropein (OLP), a polyphenol derived from olives, ameliorates epigenetic kidney aging. Upregulation and downregulation Like nearly everything in biology, this specific part of kidney aging results from a chain of events. Here, the researchers show that
Viagra Identified as a Candidate Drug for Alzheimer’s
December 10, 2021
After sifting through 1,600 FDA-approved drugs, scientists have shown that Viagra is significantly correlated with lower Alzheimer’s disease risk [1]. Re-repurposing Viagra? Viagra (sildenafil) is one of the most recognizable drugs in the world. Yet, sildenafil’s hailed effect on erectile dysfunction was discovered serendipitously. Originally, sildenafil
Chinese Licorice Plant Extract Restores Fat Stem Cells
December 9, 2021
Researchers publishing in Aging have reported that licochalcone A (LA), a flavonoid that originates from Chinese licorice, restores human adipose-derived stem cells (hADSCs) in cell culture. Reported positive effects Previous research on Licochalcone A has discovered that it has anti-inflammatory and anti-tumor effects [1], reduces obesity
Demonstration That Cord Blood Improves Progeria
December 9, 2021
A new case report published in the International Journal of Molecular Sciences highlights cardiovascular improvements in a patient with Hutchinson-Gilford progeria treated with umbilical cord blood. A case study using umbilical cord blood Cell therapy has shown potential in treating cardiovascular disease, which is also the
Hyperbaric Oxygen Causes Transcriptomic Changes
December 8, 2021
Transcriptomic results have been published regarding the Shamir Medical Center longitudinal study on hyperbaric oxygen therapy (HBOT), which was conducted between 2016 and 2020 on 35 healthy adults aged 64 and older [1]. Background Recently, we discussed misconceptions from the media on research developing on HBOT
Late-Life Treatment Extends Nematode Lifespan by Two-Fold
December 7, 2021
Scientists have managed to extend the lifespan of C. elegans nematode worms by as much as 135% by blocking an insulin-related pathway very late in life [1]. The long-lived mutants Back in the late 80s and early 90s, experiments with C. elegans, tiny nematode worms, became
Building a Universal Immunotherapy for Cancer
December 6, 2021
Researchers publishing in Cell Reports Medicine have described a method of using off-the-shelf, allogeneic immune cells as cancer therapy. Overcoming the hurdles of allogeneic cells Allogeneic cells come from other sources than the individual being treated. As recipients of organ donations know, if the immune system
Alpha-Ketoglutarate Decreases Biological Age in Human Study
December 3, 2021
A commercially available alpha-ketoglutarate-based supplement has been shown to roll back biological age by 7 years on average in a retrospective human study [1]. Live slower, die later Though metformin and rapamycin are getting most of the attention in the longevity field today, alpha-ketoglutarate (AKG) has emerged
Narrowed Neck Arteries Lead to Reduced Blood Flow in Eyes
December 2, 2021
Researchers publishing in GeroScience have found that carotid artery stenosis, a consequence of hypertension, is linked to a lack of blood flow in the eyes. A disease that restricts blood flow to the brain Carotid artery stenosis (CAS) is a dangerous condition that is strongly associated
Separating Fact from Fiction in Anti-Aging Diets
December 1, 2021
Dr. Matt Kaeberlein and colleagues recently published a review summarizing anti-aging diets as well as their misconceptions [1]. Caloric restriction, fasting-mimicking diets, and intermittent fasting While fasting diets have been practiced for centuries, a recent re-emergence of this research has come to the anti-aging field. The
Bifidobacterium Adolescentis Improves Lifespan in Animals
December 1, 2021
A new publication in Nature Aging has investigated the role of the gut bacteria Bifidobacterium adolescentis in aging and longevity. The aging gut microbiome The gut microbiome, previously thought to be relatively inconsequential, seems to play a greater role in our physiology with each published study.
Metformin Alleviates Cognitive Impairment in Long-Term Study
November 30, 2021
Scientists have confirmed yet another positive effect of metformin: its prolonged use by people with diabetes lowers the risk of cognitive impairment and cerebral small vessel disease [1]. A meta-drug? Metformin is one of the top candidate geroprotective (life-prolonging) drugs for several reasons. First, it has
Mitochondrial Calcium Uptake and Sarcopenia
November 29, 2021
A team of researchers publishing in Cell Death & Disease has found that the age-related decline of mitochondrial calcium uptake family member 3 (MICU3), a regulator of mitochondrial function, is associated with sarcopenia, the aging-associated loss of muscle. Why mitochondria control their calcium uptake The calcium
Rapamycin Prevents Stem Cells from Growing Too Big
November 26, 2021
Researchers have found that hematopoietic stem cells lose function as they grow larger and that rapamycin can alleviate this effect [1]. When cells become obese When it comes to cells, size matters, with stem cells being on the smaller side [2]. Scientists have suspected for quite some
p21 Expression Is a Delayed Death Sentence for Cells
November 25, 2021
Researchers publishing in Science have found that the well-known biomarker p21 starts a fatal timer for mouse liver cells. Get better or die As the researchers demonstrate, the cyclin-dependent kinase inhibitor p21, which is encoded by the Cdkn1a gene, is associated with its own secretome: the