Category: Biology of Aging
The Enormous Economic Benefits of Targeting Aging
July 14, 2021
Using Peter Pan, Wolverine, and a powerful economic model, a trio of prominent scientists argues that slowing aging can bring gargantuan economic benefits – an order of magnitude bigger than
NMN Enhances Aerobic Capacity in Amateur Runners
July 14, 2021
A clinical trial of endurance runners recently published in the Journal of the International Society of Sports Nutrition found nicotinamide mononucleotide (NMN) to increase several measures of aerobic capacity. Could
Telomere Loss And The Development Of Fibrosis
July 13, 2021
A new study published in Aging has shown a link between a reduction in telomerase reverse transcriptase (TERT), the gene that allows for telomere maintenance, and the development of myofibroblasts,
Senolytics Improve Spinal Cord Recovery in Mice
July 12, 2021
A new study published in Cell Reports has shown that the senolytic navitoclax (ABT-263) helps mice heal from spinal cord injuries [1]. The difference between mice and zebrafish The zebrafish
Senolytics Show Positive Results in Phase 1 Clinical Trial
July 9, 2021
Leading the pack is never easy, but today, UNITY Biotechnology is back with some positive news for senolytics. Being first is not always easy UNITY Biotechnology is a company that
Castration Lengthens Lifespan of Sheep by Altering Androgens
July 8, 2021
Researchers have shown that castration makes male sheep live longer, and they’ve also used genomic data to get a basic understanding of the mechanism behind this longevity [1]. While castration
Testosterone Restores Brain Function in Old Male Rats
July 6, 2021
Researchers from Hebei Medical University in China have found that testosterone supplementation ameliorates age-related brain dysfunction in male rats. A focus on mitochondria Previous research has shown that testosterone supplementation
Ginseng Compound Reduces Senescent Marker in Humans
July 5, 2021
A study conducted by researchers at the University of Taipei in Taiwan has shown that the ginseng derivative Rg1 decreases the cellular senescence marker p16INK4a in fitness-trained men 24 hours
Caloric Restriction Attenuates Immunosenescence
July 2, 2021
Scientists have shown in mice that long-term caloric restriction can attenuate age-related immunosenescence on par with antibody-mediated clearance of senescent T-cells. On top of that, caloric restriction predictably improved glucose
Gut Bacteria Strongly Influence the Aging Genome in Flies
July 1, 2021
Most of the genetic changes associated with increasing age disappear in the absence of gut bacteria, according to a new fruit fly study [1]. It’s a pretty surprising finding, and
Life Extension Drug Discovered by Accident
June 30, 2021
Researchers have found that zoledronate, a drug used to treat osteoporosis, has unexpected life-extending properties in human beings, and they confirmed these findings in a fruit fly study. The original
Intellia Shows CRISPR Gene Editing in Humans Has Arrived
June 28, 2021
Intellia has released clinical data for NTLA-2001, a gene therapy for hereditary transthyretin amyloidosis. What is transthyretin amyloidosis? Transthyretin (ATTR) amyloidosis is the buildup of misfolded transthyretin, a protein generated
Grey Hair Can Change Back to Original Color
June 25, 2021
Many people dread finding their first greying hairs, which is often their first sign that aging is creeping up on them and that the fire of youth is starting to
300 Years of Saving Animals, a Wildlife Guardian’s Wish
June 24, 2021
Today, we are proud to announce the second video in our Lifespan Docs series. This is part of an ongoing series of videos that focuses on the positive aspects of
Evolution Won’t Stop Aging Any Time Soon, but Medicine Might
June 24, 2021
A new study [1] about the ‘invariant rate of ageing’ has led to reports that aging is unstoppable and that we cannot cheat death. However, this reporting is based on
The Enormous Economic Benefits of Targeting Aging
July 14, 2021
Using Peter Pan, Wolverine, and a powerful economic model, a trio of prominent scientists argues that slowing aging can bring gargantuan economic benefits – an order of magnitude bigger than previously thought [1]. The marriage of economics and geroscience The paper, published in Nature Aging, looks
NMN Enhances Aerobic Capacity in Amateur Runners
July 14, 2021
A clinical trial of endurance runners recently published in the Journal of the International Society of Sports Nutrition found nicotinamide mononucleotide (NMN) to increase several measures of aerobic capacity. Could NMN and exercise be synergistic? NMN is a NAD+ precursor well known to longevity researchers for
Telomere Loss And The Development Of Fibrosis
July 13, 2021
A new study published in Aging has shown a link between a reduction in telomerase reverse transcriptase (TERT), the gene that allows for telomere maintenance, and the development of myofibroblasts, cells that are a part of organ fibrosis. It also documents the link between telomere attrition
Senolytics Improve Spinal Cord Recovery in Mice
July 12, 2021
A new study published in Cell Reports has shown that the senolytic navitoclax (ABT-263) helps mice heal from spinal cord injuries [1]. The difference between mice and zebrafish The zebrafish is a well-known species studied for its regenerative abilities, so the researchers began their investigation by
Senolytics Show Positive Results in Phase 1 Clinical Trial
July 9, 2021
Leading the pack is never easy, but today, UNITY Biotechnology is back with some positive news for senolytics. Being first is not always easy UNITY Biotechnology is a company that has been developing senolytics for the removal of senescent cells, which accumulate with age, drive chronic
Castration Lengthens Lifespan of Sheep by Altering Androgens
July 8, 2021
Researchers have shown that castration makes male sheep live longer, and they’ve also used genomic data to get a basic understanding of the mechanism behind this longevity [1]. While castration is unlikely to be part of a life extension therapy, unraveling its effect on lifespan will
Testosterone Restores Brain Function in Old Male Rats
July 6, 2021
Researchers from Hebei Medical University in China have found that testosterone supplementation ameliorates age-related brain dysfunction in male rats. A focus on mitochondria Previous research has shown that testosterone supplementation helps offset some of the symptoms of Alzheimer’s disease [1] and Parkinson’s disease [2] in men.
Ginseng Compound Reduces Senescent Marker in Humans
July 5, 2021
A study conducted by researchers at the University of Taipei in Taiwan has shown that the ginseng derivative Rg1 decreases the cellular senescence marker p16INK4a in fitness-trained men 24 hours after exercise. An experiment to link p16INK4a, aging, exercise, and Rg1 The cell cycle inhibitor p16INK4a,
Caloric Restriction Attenuates Immunosenescence
July 2, 2021
Scientists have shown in mice that long-term caloric restriction can attenuate age-related immunosenescence on par with antibody-mediated clearance of senescent T-cells. On top of that, caloric restriction predictably improved glucose tolerance and lowered inflammation [1]. Senescent cells: inflamed and half-dead Immunosenescence is an umbrella term for
Gut Bacteria Strongly Influence the Aging Genome in Flies
July 1, 2021
Most of the genetic changes associated with increasing age disappear in the absence of gut bacteria, according to a new fruit fly study [1]. It’s a pretty surprising finding, and while there are some important implications, it’s also a bit challenging to interpret. A flat aging
Life Extension Drug Discovered by Accident
June 30, 2021
Researchers have found that zoledronate, a drug used to treat osteoporosis, has unexpected life-extending properties in human beings, and they confirmed these findings in a fruit fly study. The original unexpected findings Zoledronate is a biophosphonate, a drug used to strengthen bones and reduce the risk
Intellia Shows CRISPR Gene Editing in Humans Has Arrived
June 28, 2021
Intellia has released clinical data for NTLA-2001, a gene therapy for hereditary transthyretin amyloidosis. What is transthyretin amyloidosis? Transthyretin (ATTR) amyloidosis is the buildup of misfolded transthyretin, a protein generated by the liver. Normally, this protein is partially responsible for the transport of thyroid hormones, hence
Grey Hair Can Change Back to Original Color
June 25, 2021
Many people dread finding their first greying hairs, which is often their first sign that aging is creeping up on them and that the fire of youth is starting to die down and smolder. To some readers, greying hair may seem to be a superficial issue;
300 Years of Saving Animals, a Wildlife Guardian’s Wish
June 24, 2021
Today, we are proud to announce the second video in our Lifespan Docs series. This is part of an ongoing series of videos that focuses on the positive aspects of a world in which healthy life extension is possible. As part of that, we are making
Evolution Won’t Stop Aging Any Time Soon, but Medicine Might
June 24, 2021
A new study [1] about the ‘invariant rate of ageing’ has led to reports that aging is unstoppable and that we cannot cheat death. However, this reporting is based on a misunderstanding of what the study actually says. The misinterpretations The study shows that “immortality and