Category: Biology of Aging
Intermittent Fasting During Ramadan Alters Gut Bacteria
May 13, 2021
Intermittent fasting changes the composition of the gut microbiome, according to new research [1]. An increase in the abundance of a group of bacteria known as Lachnospiraceae may explain some
DHE Reduces Inflammation, Senescence in Intervertebral Discs
May 12, 2021
Recent research out of Frontiers in Pharmacology has shown that a natural herbal compound reduces senescence and intervertebral disc degeneration in mice. Cellular senescence in intervertebral disc degeneration Located between
Some People think Life Extension is “Just a Fear of Death”
May 11, 2021
Sometimes those working in the field of rejuvenation biotechnology face the accusation that what they are doing is just a fear of death, like not being scared of age-related diseases
Gene Therapy Improves the Brains of Mice With Alzheimer’s
May 11, 2021
Scientists have successfully improved learning and memory, as well as neuronal morphology, in Alzheimer’s-prone mice with the help of a gene therapy that upregulates a vital protein [1]. Alzheimer’s disease
Harnessing the Unaging Germline
May 10, 2021
A team of researchers, including Michael West of AgeX Therapeutics, has authored a review paper that posits a fundamental difference between “immortal” germline cells and “mortal” somatic cells. The two
Aging Begins After a Rejuvenation Event in Early Life
May 10, 2021
The Journal Club hosted by Dr. Oliver Medvedik returns for another episode on May 25th at noon Eastern / 5 UK time live on our Facebook page. This month, we
People Living 105+ Years Appear to Repair DNA Better
May 7, 2021
A new study has shown that people who live for over 105 years typically have a genetic makeup that allows better repair of DNA damage [1]. Looking at the genomes
No Sign of Aging in Long-Lived Bigmouth Buffalo Fish
May 6, 2021
Extremely long-lived bigmouth buffalo fish show no signs of a physiological decline with age, according to a new study. This clear example of negligible senescence in aging vertebrates demonstrates the
Kizoo Technology Pledges €300 Million to Rejuvenation
May 6, 2021
It is always good to report on positive news for a change, and today is one of those happy occasions. Michael Greve, founder of Forever Healthy and Kizoo, has commited
Vibration Reduces Cellular Senescence in the Bones of Rats
May 5, 2021
A new study published in the journal Aging has examined the effects of vibration on cellular senescence and osteoporosis. Superior treatments are needed for osteoporosis Typically, bone density peaks for
Rapamycin Reduces Age-Related Hearing Loss in Mice
May 4, 2021
Researchers have found that rapamycin supplementation attenuates but not reverses age-related hearing loss in mice, even if the treatment starts later in life [1]. Hear ye, aging is coming Gradual
Phase 2 Trial Of Gene Therapy For Diabetic Macular Edema
May 3, 2021
Following a significant adverse event in which a patient lost vision in an eye treated with ADVM-022, Adverum Biotechnologies has unveiled the details of its Phase 2 trial of this
Some Argue that Increased Longevity Would Cause Scarcity
May 3, 2021
The discussion of increased lifespans through medical and technological methods of addressing the various processes of aging raises the concern that this could lead to a lack of resources and result in conflict
Some People Worry that Longer Lives Mean Decrepitude
April 30, 2021
Whenever the topic of increasing human lifespan is discussed, the concern is sometimes raised that a longer life would mean a life spent frail and decrepit. This is sometimes known
The Blood-Brain Barrier’s Role in Brain Aging
April 30, 2021
Research suggests that the degradation of the blood-brain barrier over time is a factor in the development of brain diseases. An organ we don’t want to age As our brains
Intermittent Fasting During Ramadan Alters Gut Bacteria
May 13, 2021
Intermittent fasting changes the composition of the gut microbiome, according to new research [1]. An increase in the abundance of a group of bacteria known as Lachnospiraceae may explain some of the health benefits linked with dietary restriction. A natural experiment Intermittent fasting—the repeated, severe restriction
DHE Reduces Inflammation, Senescence in Intervertebral Discs
May 12, 2021
Recent research out of Frontiers in Pharmacology has shown that a natural herbal compound reduces senescence and intervertebral disc degeneration in mice. Cellular senescence in intervertebral disc degeneration Located between our vertebral bones, intervertebral discs are the shock-absorbing tissues that allow the spine to bend. Like
Some People think Life Extension is “Just a Fear of Death”
May 11, 2021
Sometimes those working in the field of rejuvenation biotechnology face the accusation that what they are doing is just a fear of death, like not being scared of age-related diseases is somehow brave. War used to be fashionable but now it isn’t These days, war is
Gene Therapy Improves the Brains of Mice With Alzheimer’s
May 11, 2021
Scientists have successfully improved learning and memory, as well as neuronal morphology, in Alzheimer’s-prone mice with the help of a gene therapy that upregulates a vital protein [1]. Alzheimer’s disease (AD) has been a notoriously hard problem to crack, despite major R&D investment. AD has long
Harnessing the Unaging Germline
May 10, 2021
A team of researchers, including Michael West of AgeX Therapeutics, has authored a review paper that posits a fundamental difference between “immortal” germline cells and “mortal” somatic cells. The two types of cells This review paper, which cites 175 other papers, goes back throughout history, discussing
Aging Begins After a Rejuvenation Event in Early Life
May 10, 2021
The Journal Club hosted by Dr. Oliver Medvedik returns for another episode on May 25th at noon Eastern / 5 UK time live on our Facebook page. This month, we have one of the authors, Dr. Vadim Gladyshev, joining us, and he will be talking us
People Living 105+ Years Appear to Repair DNA Better
May 7, 2021
A new study has shown that people who live for over 105 years typically have a genetic makeup that allows better repair of DNA damage [1]. Looking at the genomes of people who enjoy extreme longevity There has always been lots of interest in what allows
No Sign of Aging in Long-Lived Bigmouth Buffalo Fish
May 6, 2021
Extremely long-lived bigmouth buffalo fish show no signs of a physiological decline with age, according to a new study. This clear example of negligible senescence in aging vertebrates demonstrates the need to better understand the mechanisms underlying senescence and points the way towards research that could
Kizoo Technology Pledges €300 Million to Rejuvenation
May 6, 2021
It is always good to report on positive news for a change, and today is one of those happy occasions. Michael Greve, founder of Forever Healthy and Kizoo, has commited €300 million (just over $360 million at the time of writing) to support the development of
Vibration Reduces Cellular Senescence in the Bones of Rats
May 5, 2021
A new study published in the journal Aging has examined the effects of vibration on cellular senescence and osteoporosis. Superior treatments are needed for osteoporosis Typically, bone density peaks for individuals around age 30 and then declines with age. While osteoporosis is rarely a direct cause
Rapamycin Reduces Age-Related Hearing Loss in Mice
May 4, 2021
Researchers have found that rapamycin supplementation attenuates but not reverses age-related hearing loss in mice, even if the treatment starts later in life [1]. Hear ye, aging is coming Gradual hearing loss might not be as physically harmful as cancer, Alzheimer’s or many other age-related pathologies,
Phase 2 Trial Of Gene Therapy For Diabetic Macular Edema
May 3, 2021
Following a significant adverse event in which a patient lost vision in an eye treated with ADVM-022, Adverum Biotechnologies has unveiled the details of its Phase 2 trial of this gene therapy for diabetic macular edema. An overgrowth of blood vessels Wet age-related macular degeneration (AMD)
Some Argue that Increased Longevity Would Cause Scarcity
May 3, 2021
The discussion of increased lifespans through medical and technological methods of addressing the various processes of aging raises the concern that this could lead to a lack of resources and result in conflict and suffering. The argument suggests that we will run out of resources if we develop the technology
Some People Worry that Longer Lives Mean Decrepitude
April 30, 2021
Whenever the topic of increasing human lifespan is discussed, the concern is sometimes raised that a longer life would mean a life spent frail and decrepit. This is sometimes known as the Tithonus error and shows a fundamental misunderstanding of the aims of rejuvenation biotechnology. The
The Blood-Brain Barrier’s Role in Brain Aging
April 30, 2021
Research suggests that the degradation of the blood-brain barrier over time is a factor in the development of brain diseases. An organ we don’t want to age As our brains age, we experience memory loss, a decreased ability to multitask, a lower attention span, and slower