Category: Biology of Aging
A Mechanism Behind Protein Aggregation Discovered
September 5, 2025
Scientists have found a pathway that regulates protein aggregation, a cause of several age-related neurodegenerative diseases. United by abnormal protein aggregation Most neurodegenerative diseases are age-related, and many of them
Cancer Cells Transfer Mitochondria to Fibroblasts
September 3, 2025
Scientists have discovered that cancer cells recruit fibroblasts to support tumor growth by transferring mitochondria into them. Blocking this process might be a new way to fight the deadly disease
A Non-Viral Gene Therapy Restores Mouse Hearts
September 3, 2025
A recent study investigated the roles of brown adipose tissue and a lipid-controlling hormone, 12,13-diHOME, in cardiac health. The researchers examined the molecular mechanisms behind 12,13-diHOME’s effects on the hearts
Moderate Beer Consumption Produces Benefits in Mice
August 29, 2025
Scientists have given three types of beer to artificially aged male mice and recorded numerous beneficial effects, including improvements in microbiome diversity and lipid profiles [1]. Can alcohol be healthy?
Loose Chromatin, Senescent Inflammation, and Cancer
August 28, 2025
In Aging Cell, researchers have reported that chromatin demethylation allows SASP compounds to be more easily expressed. Chromatin and gene expression The authors of this study begin by discussing two
Rejuvenating Atherosclerotic Foam Cells
August 27, 2025
According to a study published by Cyclarity Therapeutics, its drug UDP-003 shows benefits in reversing the root cause of atherosclerotic plaques [1]. Fighting the root cause Many available medications address
Impaired Brain Blood Flow Might Be Important in Alzheimer’s
August 26, 2025
Scientists have developed a potent diagnostic tool based on the vascular hypothesis for Alzheimer’s. It outperformed three current techniques and might offer clues to the mechanism behind the disease [1].
Reducing an Iron-Associated Protein Fights Cognitive Decline
August 25, 2025
In Nature Aging, researchers have described how an increase in the iron-associated protein ferritin light chain 1 (FTL1) is related to age-related cognitive impairment. Impairment without cellular death While neuronal
Transient Epigenetic Rejuvenation Recorded in Athletes
August 22, 2025
A new study has found that professional soccer players experience a drop in their biological age after a match, as measured by biomarkers assessed with state-of-the-art methylation clocks [1]. We
Researchers Identify a Key Senescence-Spreading Factor
August 21, 2025
In Metabolism Clinical & Experimental, researchers have described how the reduced isoform of the SASP factor HMGB1 causes senescence to spread. An alarm that doesn’t turn off HMGB1 is an
Low-Dose Lithium Reverses Features of Alzheimer’s in Mice
August 20, 2025
In a recent study, researchers identified the critical role that lithium plays in brain health and the development of mild cognitive impairment and Alzheimer’s disease. Supplementing with a lithium salt
An Overly Youthful Immune System Might Cause Autoimmunity
August 19, 2025
Scientists have proposed a hypothesis that immune aging might be necessary to shield people from autoimmune effects, as the repertoire of autoantigens expands with age [1]. A double-edged sword? The
Exosomes Reduce Sarcopenia in a Mouse Model
August 18, 2025
Researchers have discovered that exosomes secreted by mesenchymal stem cells derived from human umbilical cord tissue (hucMSC-Exos) restore muscle function in a mouse model of sarcopenia. Useful messengers Exosomes are
How Inflammation Is Linked to Heart Disease
August 14, 2025
In Cell Reports Medicine, researchers have published a detailed review on the relationship between cardiovascular disease and the age-related inflammation known as inflammaging. The immune system itself ages Inflammaging occurs
Cannabis as a Treatment for Age-Related Diseases
August 13, 2025
Researchers have recently published a review on how cannabis use among older adults impacts age-related conditions and longevity [1]. Cannabinoids and longevity In recent years, researchers have observed an increase
A Mechanism Behind Protein Aggregation Discovered
September 5, 2025
Scientists have found a pathway that regulates protein aggregation, a cause of several age-related neurodegenerative diseases. United by abnormal protein aggregation Most neurodegenerative diseases are age-related, and many of them are similar in other ways. For instance, amyotrophic lateral sclerosis (ALS), Huntington’s disease, and Alzheimer’s disease
Cancer Cells Transfer Mitochondria to Fibroblasts
September 3, 2025
Scientists have discovered that cancer cells recruit fibroblasts to support tumor growth by transferring mitochondria into them. Blocking this process might be a new way to fight the deadly disease [1]. It goes both ways Cancer doesn’t act alone. Its success often hinges on recruiting neighboring
A Non-Viral Gene Therapy Restores Mouse Hearts
September 3, 2025
A recent study investigated the roles of brown adipose tissue and a lipid-controlling hormone, 12,13-diHOME, in cardiac health. The researchers examined the molecular mechanisms behind 12,13-diHOME’s effects on the hearts of aged mice [1]. The aging heart Aging leads to many cardiovascular system-related changes, which are
Moderate Beer Consumption Produces Benefits in Mice
August 29, 2025
Scientists have given three types of beer to artificially aged male mice and recorded numerous beneficial effects, including improvements in microbiome diversity and lipid profiles [1]. Can alcohol be healthy? While it is firmly established that excessive alcohol consumption negatively impacts health, debates around moderate consumption
Loose Chromatin, Senescent Inflammation, and Cancer
August 28, 2025
In Aging Cell, researchers have reported that chromatin demethylation allows SASP compounds to be more easily expressed. Chromatin and gene expression The authors of this study begin by discussing two concepts that appear only loosely related: senescence and gene expression. Both of these concepts are very
Rejuvenating Atherosclerotic Foam Cells
August 27, 2025
According to a study published by Cyclarity Therapeutics, its drug UDP-003 shows benefits in reversing the root cause of atherosclerotic plaques [1]. Fighting the root cause Many available medications address only disease symptoms in an effort to mitigate them. However, the real challenge is to identify
Impaired Brain Blood Flow Might Be Important in Alzheimer’s
August 26, 2025
Scientists have developed a potent diagnostic tool based on the vascular hypothesis for Alzheimer’s. It outperformed three current techniques and might offer clues to the mechanism behind the disease [1]. The blood flow hypothesis Traditionally, Alzheimer’s disease has been associated with the presence of amyloid plaques
Reducing an Iron-Associated Protein Fights Cognitive Decline
August 25, 2025
In Nature Aging, researchers have described how an increase in the iron-associated protein ferritin light chain 1 (FTL1) is related to age-related cognitive impairment. Impairment without cellular death While neuronal loss is always a concern, age-related cognitive decline has been found to be primarily driven by
Transient Epigenetic Rejuvenation Recorded in Athletes
August 22, 2025
A new study has found that professional soccer players experience a drop in their biological age after a match, as measured by biomarkers assessed with state-of-the-art methylation clocks [1]. We asked Dr. Steve Horvath, the study’s co-author, to comment. Clocks, stress, and exercise Epigenetic clocks have
Researchers Identify a Key Senescence-Spreading Factor
August 21, 2025
In Metabolism Clinical & Experimental, researchers have described how the reduced isoform of the SASP factor HMGB1 causes senescence to spread. An alarm that doesn’t turn off HMGB1 is an alarmin protein, which, as its name suggests, is released as a response to damage, making it
Low-Dose Lithium Reverses Features of Alzheimer’s in Mice
August 20, 2025
In a recent study, researchers identified the critical role that lithium plays in brain health and the development of mild cognitive impairment and Alzheimer’s disease. Supplementing with a lithium salt called lithium orotate can reverse many of its cognitive decline-related changes on the molecular and cellular
An Overly Youthful Immune System Might Cause Autoimmunity
August 19, 2025
Scientists have proposed a hypothesis that immune aging might be necessary to shield people from autoimmune effects, as the repertoire of autoantigens expands with age [1]. A double-edged sword? The decline of the immune system is a major driver of aging, making us more susceptible to
Exosomes Reduce Sarcopenia in a Mouse Model
August 18, 2025
Researchers have discovered that exosomes secreted by mesenchymal stem cells derived from human umbilical cord tissue (hucMSC-Exos) restore muscle function in a mouse model of sarcopenia. Useful messengers Exosomes are vesicles that carry molecular messages from cell to cell. When derived from youthful sources, they have
How Inflammation Is Linked to Heart Disease
August 14, 2025
In Cell Reports Medicine, researchers have published a detailed review on the relationship between cardiovascular disease and the age-related inflammation known as inflammaging. The immune system itself ages Inflammaging occurs in both the cells sending out signals and in the cells receiving them. The numbers of
Cannabis as a Treatment for Age-Related Diseases
August 13, 2025
Researchers have recently published a review on how cannabis use among older adults impacts age-related conditions and longevity [1]. Cannabinoids and longevity In recent years, researchers have observed an increase in cannabis use among older adults, mostly for chronic conditions, such as arthritis, pain, sleep improvement,