Category: Research
Study Finds Metformin’s Action Is Regulated by the Brain
August 1, 2025
A new study has shown that, unlike many other glucose-lowering drugs, metformin is regulated by the protein Ras1 in a specific subset of neurons, and when injected into the brain,
Senescent Cells, Osteoporosis, and Alzheimer’s Are Linked
July 31, 2025
Researchers publishing in Nature Aging have discovered how Alzheimer’s-related protein aggregates are also related to senescent cells and osteoporosis. Beyond the brain The amyloid tangles that result from a loss
Rejuvenating Muscles in Mice With Senomorphic Treatment
July 30, 2025
A recent study investigated senescence in mouse and human skeletal muscle tissue. The authors demonstrated that the antiviral drug maraviroc reduces senescence and improves muscle health in aged mice [1].
Fighting Osteoarthritis by Targeting Fatty Acids
July 28, 2025
In the Cell journal iScience, researchers have published their discovery of a protein that inhibits osteoarthritis in mice by diminishing fatty acid production. Fats in the wrong place Previous work
A Gene That Keeps Cells Under Control
July 24, 2025
Researchers publishing in Cell Stem Cell have investigated the function of the gene DNMT3A and found that it has wide-ranging effects beyond methylation. More effects than expected Clonal hematopoiesis (CH),
Organ-Specific Aging Analysis Reveals Disease Connections
July 23, 2025
A recent study explored the differences in the speed of organ aging. The researchers have built models that can predict the odds of diseases and mortality risk based on organ-specific
FDA-Approved Drug Combo Rescues Alzheimer’s in Mice
July 22, 2025
Scientists have creatively used large databases of existing FDA-approved drugs and electronic medical records to locate candidates that are potentially effective against Alzheimer’s [1]. New approaches needed Many previously discovered
Vesicles From Antler Cells Restore Bone in Monkeys
July 21, 2025
Researchers publishing in Nature Aging have discovered that extracellular vesicles (EVs) derived from antler blastema progenitor cells (ABPCs) restore bone mass to rhesus macaques. Finding the most effective EVs In
AI Reveals a Hidden Effect in a Failed Alzheimer’s Trial
July 18, 2025
Scientists have created an AI model that stratifies Alzheimer’s patients into subgroups that progress slowly or rapidly. When applied to a real-world failed trial, it revealed a robust effect in
Engineered Stem Cells Reduce Lung Fibrosis in Mice
July 17, 2025
In Molecular Therapy, researchers have described their creation of cells that express the regenerative factor GDF11 and found that they ameliorate fibrosis in a mouse model. Context-dependent benefits Like sirtuins
A Hallucinogenic Mushroom Compound Extends Mouse Lifespan
July 16, 2025
Researchers investigated psilocybin, a psychedelic compound found in hallucinogenic mushrooms, for its anti-aging properties. They found that it extends cellular and organismal lifespan, even when administered later in life [1].
Non-Toxic Stem Cell Transplantation Prevents Cancer in Mice
July 15, 2025
Scientists have developed a protocol for hematopoietic stem cell transplantation that reconstructs a healthy blood system and prevents blood cancers in old mice while also reducing toxicity [1]. The blood
How Blood-Brain Barrier Leaks Make Parkinson’s Worse
July 14, 2025
Researchers have discovered how α-synuclein (α-syn), a key protein in Parkinson’s disease and Lewy body dementia, leads to inflammation and disruption of the axons in the brain. Failure of the
Scientists Successfully Edit Mitochondrial DNA
July 11, 2025
A new study demonstrates that novel gene-editing tools can correct disease-causing mutations in mitochondrial DNA in primary human cells [1]. Smaller editing tools needed Genome-editing tools such as CRISPR were
Senolytics May Affect Inflammation-Related Cognitive Decline
July 10, 2025
Researchers have found that inflamed, senescent microglia prune too many synapses in the hippocampus and demonstrated that a senolytic compound can ameliorate this process in Aging Cell. Some synapse pruning
Study Finds Metformin’s Action Is Regulated by the Brain
August 1, 2025
A new study has shown that, unlike many other glucose-lowering drugs, metformin is regulated by the protein Ras1 in a specific subset of neurons, and when injected into the brain, even tiny doses of metformin can do the job [1]. The brain connection The safe and
Senescent Cells, Osteoporosis, and Alzheimer’s Are Linked
July 31, 2025
Researchers publishing in Nature Aging have discovered how Alzheimer’s-related protein aggregates are also related to senescent cells and osteoporosis. Beyond the brain The amyloid tangles that result from a loss of proteostasis are very well-known in the context of Alzheimer’s and other neurodegenerative diseases. However, amyloid
Rejuvenating Muscles in Mice With Senomorphic Treatment
July 30, 2025
A recent study investigated senescence in mouse and human skeletal muscle tissue. The authors demonstrated that the antiviral drug maraviroc reduces senescence and improves muscle health in aged mice [1]. Aging muscle tissue Senescent cells are one of the hallmarks of aging. One of their key
Fighting Osteoarthritis by Targeting Fatty Acids
July 28, 2025
In the Cell journal iScience, researchers have published their discovery of a protein that inhibits osteoarthritis in mice by diminishing fatty acid production. Fats in the wrong place Previous work has found a strong link between obesity and osteoarthritis of the knee [1]. While the increased
A Gene That Keeps Cells Under Control
July 24, 2025
Researchers publishing in Cell Stem Cell have investigated the function of the gene DNMT3A and found that it has wide-ranging effects beyond methylation. More effects than expected Clonal hematopoiesis (CH), which occurs when stem cells create large numbers of cells with the same mutation, is linked
Organ-Specific Aging Analysis Reveals Disease Connections
July 23, 2025
A recent study explored the differences in the speed of organ aging. The researchers have built models that can predict the odds of diseases and mortality risk based on organ-specific proteins found in plasma [1]. Not all organs age equally Since each organ in the human
FDA-Approved Drug Combo Rescues Alzheimer’s in Mice
July 22, 2025
Scientists have creatively used large databases of existing FDA-approved drugs and electronic medical records to locate candidates that are potentially effective against Alzheimer’s [1]. New approaches needed Many previously discovered drugs may be effective beyond their original indications, but it is challenging to match them to
Vesicles From Antler Cells Restore Bone in Monkeys
July 21, 2025
Researchers publishing in Nature Aging have discovered that extracellular vesicles (EVs) derived from antler blastema progenitor cells (ABPCs) restore bone mass to rhesus macaques. Finding the most effective EVs In the world of rejuvenation research, EVs are nothing new. We have covered them extensively, as studies
AI Reveals a Hidden Effect in a Failed Alzheimer’s Trial
July 18, 2025
Scientists have created an AI model that stratifies Alzheimer’s patients into subgroups that progress slowly or rapidly. When applied to a real-world failed trial, it revealed a robust effect in the former subgroup [1]. Stratify and conquer Drugs don’t work for everyone equally. Unfortunately, clinical trials
Engineered Stem Cells Reduce Lung Fibrosis in Mice
July 17, 2025
In Molecular Therapy, researchers have described their creation of cells that express the regenerative factor GDF11 and found that they ameliorate fibrosis in a mouse model. Context-dependent benefits Like sirtuins and klotho, GDF11 is a biochemical factor that has been heavily investigated in the context of
A Hallucinogenic Mushroom Compound Extends Mouse Lifespan
July 16, 2025
Researchers investigated psilocybin, a psychedelic compound found in hallucinogenic mushrooms, for its anti-aging properties. They found that it extends cellular and organismal lifespan, even when administered later in life [1]. From ancient times to contemporary therapies Hallucinogenic mushrooms have a long history of use, reaching back
Non-Toxic Stem Cell Transplantation Prevents Cancer in Mice
July 15, 2025
Scientists have developed a protocol for hematopoietic stem cell transplantation that reconstructs a healthy blood system and prevents blood cancers in old mice while also reducing toxicity [1]. The blood factory Hematopoietic stem cells (HSCs) work hard for our entire lives, producing vast numbers of various
How Blood-Brain Barrier Leaks Make Parkinson’s Worse
July 14, 2025
Researchers have discovered how α-synuclein (α-syn), a key protein in Parkinson’s disease and Lewy body dementia, leads to inflammation and disruption of the axons in the brain. Failure of the barrier Unlike other organs, the brain is heavily protected from many compounds in the bloodstream in
Scientists Successfully Edit Mitochondrial DNA
July 11, 2025
A new study demonstrates that novel gene-editing tools can correct disease-causing mutations in mitochondrial DNA in primary human cells [1]. Smaller editing tools needed Genome-editing tools such as CRISPR were one of the greatest scientific breakthroughs of this century. However, they are only good for editing
Senolytics May Affect Inflammation-Related Cognitive Decline
July 10, 2025
Researchers have found that inflamed, senescent microglia prune too many synapses in the hippocampus and demonstrated that a senolytic compound can ameliorate this process in Aging Cell. Some synapse pruning is normal During brain development, the resident immune cells of the brain (microglia) prune unneeded synapses