Category: Research
Need for Cholesterol May Explain Alzheimer’s Brain Patterns
March 28, 2025
Some brain regions are more vulnerable to Alzheimer’s disease than others. A new study suggests that this might be due to how they uptake cholesterol [1]. Why do some parts
Researchers Find New Target for Spinal Disc Degeneration
March 27, 2025
Researchers have found a new avenue for approaching spinal disc degeneration and published their work in Aging Cell. A very common problem Back problems in the elderly are widely known
Heat May Speed Up Epigenetic Aging in Older Adults
March 26, 2025
A recent study reported significant associations between increased heat days and accelerated epigenetic aging [1]. Heat alters DNA While warm summer days on the beach are pleasant, extreme heat is
Anti-Amyloid Drug Reduces Alzheimer’s Risk in Small Subgroup
March 25, 2025
According to an open-label study from Washington University in St. Louis, the anti-amyloid drug gantenerumab reduced the risk of developing familial Alzheimer’s disease in a subgroup of participants [1]. Is
Scientists Create Cytoskeleton-Like Structures From RNA
March 21, 2025
In a new study, researchers report producing self-assembling nanotubes and rings made from RNA molecules inside artificial cell-like lipid vesicles. In the future, this technology could facilitate the creation of
A Hypothalamus Neuropeptide Reduces Aging in a Mouse Model
March 19, 2025
Researchers have improved multiple health metrics in prematurely aged mice by re-establishing the production of neuropeptide Y in the hypothalamus [1]. An essential protein Age-related decline in the function of
Short-Term Overeating Alters Brain Insulin Sensitivity
March 18, 2025
A new study published in Nature Metabolism suggests that even a short period of eating loads of sweet and fatty snacks can cause brain changes reminiscent of those seen in
Elamipretide, a Potential New Drug, Reduces Frailty in Mice
March 17, 2025
In Aging Cell, Dr. Vadim Gladyshev and a team of researchers have described how elamipretide beneficially affects mitochondrial pathways and reverses frailty in mice. A drug on its way to
Cellular Senescence Prevents Unlearning in Some Male Mice
March 13, 2025
In Aging Cell, researchers have established a link between cellular senescence and cognitive decline in unmodified male mice. Resilience versus decline The authors begin their paper by noting that cognitive
An Existing Diabetes Drug May Treat Aspects of Aging
March 10, 2025
In the Nature publication Signal Transduction and Targeted Therapy, researchers have described how glibenclamide, a drug used to treat type 2 diabetes, partially reverses epigenetic alterations and fights cellular senescence
A Klotho Gene Therapy Extends Life in Male Mice
March 6, 2025
In Molecular Therapy, a team of researchers has described how increasing the expression of a form of Klotho, a protein that has been frequently found to have rejuvenative effects, leads
Ginkgolide B Improves Healthspan and Lifespan in Female Mice
March 5, 2025
The authors of a recent study describe Ginkgolide B, a compound with senotherapeutic potential that improved muscle health, metabolism, frailty, inflammation, and senescence metrics and increased lifespan in female mice
Genes Affect Aging and Mortality Less Than Extrinsic Factors
March 4, 2025
A massive study from the University of Oxford has evaluated the relative impact of genetic and non-genetic factors on aging, mortality, and disease prevalence. A deeper dive The question of
A Protein That Controls Senescent Cell Structure
February 28, 2025
Researchers publishing in Cellular Signaling have explained how the protein AP2A1 affects stress fibers that change with cellular senescence. Stress fibers Stress fibers naturally hold cells into their proper shape.
Effects of Estradiol and Progesterone on Knee Osteoarthritis
February 26, 2025
Recent research has addressed menopause-related molecular processes that impact the high prevalence of knee osteoarthritis in post-menopausal women. Restoration of female sex hormones in a post-menopausal mouse model improved joint
Need for Cholesterol May Explain Alzheimer’s Brain Patterns
March 28, 2025
Some brain regions are more vulnerable to Alzheimer’s disease than others. A new study suggests that this might be due to how they uptake cholesterol [1]. Why do some parts of the brain succumb earlier? Despite decades of research and vast amounts of funding, scientists still
Researchers Find New Target for Spinal Disc Degeneration
March 27, 2025
Researchers have found a new avenue for approaching spinal disc degeneration and published their work in Aging Cell. A very common problem Back problems in the elderly are widely known to be caused by a deteriorating spine. Some of these problems are due to the vertebrae
Heat May Speed Up Epigenetic Aging in Older Adults
March 26, 2025
A recent study reported significant associations between increased heat days and accelerated epigenetic aging [1]. Heat alters DNA While warm summer days on the beach are pleasant, extreme heat is not as enjoyable, especially in daily life. It is also not healthy, since extreme heat has
Anti-Amyloid Drug Reduces Alzheimer’s Risk in Small Subgroup
March 25, 2025
According to an open-label study from Washington University in St. Louis, the anti-amyloid drug gantenerumab reduced the risk of developing familial Alzheimer’s disease in a subgroup of participants [1]. Is it about amyloid beta? Despite billions of dollars invested in developing therapies against Alzheimer’s disease, the
Scientists Create Cytoskeleton-Like Structures From RNA
March 21, 2025
In a new study, researchers report producing self-assembling nanotubes and rings made from RNA molecules inside artificial cell-like lipid vesicles. In the future, this technology could facilitate the creation of synthetic cells for various research, diagnostic, and therapeutic applications [1]. Paperless origami DNA and RNA molecules
A Hypothalamus Neuropeptide Reduces Aging in a Mouse Model
March 19, 2025
Researchers have improved multiple health metrics in prematurely aged mice by re-establishing the production of neuropeptide Y in the hypothalamus [1]. An essential protein Age-related decline in the function of the hypothalamus, a core region of the brain, has been suggested to be a “key factor
Short-Term Overeating Alters Brain Insulin Sensitivity
March 18, 2025
A new study published in Nature Metabolism suggests that even a short period of eating loads of sweet and fatty snacks can cause brain changes reminiscent of those seen in obesity and type 2 diabetes [1]. What can go wrong in five days? If you usually
Elamipretide, a Potential New Drug, Reduces Frailty in Mice
March 17, 2025
In Aging Cell, Dr. Vadim Gladyshev and a team of researchers have described how elamipretide beneficially affects mitochondrial pathways and reverses frailty in mice. A drug on its way to the clinic As a mitochondria-affecting antioxidant peptide, elamipretide has been, and continues to be, the subject
Cellular Senescence Prevents Unlearning in Some Male Mice
March 13, 2025
In Aging Cell, researchers have established a link between cellular senescence and cognitive decline in unmodified male mice. Resilience versus decline The authors begin their paper by noting that cognitive decline in older people varies greatly. Some people suffer serious cognitive defects; other people are scarcely
An Existing Diabetes Drug May Treat Aspects of Aging
March 10, 2025
In the Nature publication Signal Transduction and Targeted Therapy, researchers have described how glibenclamide, a drug used to treat type 2 diabetes, partially reverses epigenetic alterations and fights cellular senescence in mice. A system tightly tied together This paper begins with a discussion of the relationship
A Klotho Gene Therapy Extends Life in Male Mice
March 6, 2025
In Molecular Therapy, a team of researchers has described how increasing the expression of a form of Klotho, a protein that has been frequently found to have rejuvenative effects, leads to longer lifespans in male mice. Klotho has various forms In their introduction, the researchers distinguish
Ginkgolide B Improves Healthspan and Lifespan in Female Mice
March 5, 2025
The authors of a recent study describe Ginkgolide B, a compound with senotherapeutic potential that improved muscle health, metabolism, frailty, inflammation, and senescence metrics and increased lifespan in female mice [1]. From East Asia to the clinic Ginkgolide B is a compound that can be extracted
Genes Affect Aging and Mortality Less Than Extrinsic Factors
March 4, 2025
A massive study from the University of Oxford has evaluated the relative impact of genetic and non-genetic factors on aging, mortality, and disease prevalence. A deeper dive The question of how strongly genes affect our longevity has been asked before, and the emerging answer is not
A Protein That Controls Senescent Cell Structure
February 28, 2025
Researchers publishing in Cellular Signaling have explained how the protein AP2A1 affects stress fibers that change with cellular senescence. Stress fibers Stress fibers naturally hold cells into their proper shape. They are made out of the common protein actin and linked together by α-actinin and a
Effects of Estradiol and Progesterone on Knee Osteoarthritis
February 26, 2025
Recent research has addressed menopause-related molecular processes that impact the high prevalence of knee osteoarthritis in post-menopausal women. Restoration of female sex hormones in a post-menopausal mouse model improved joint health [1]. A centuries-old observation The authors start the article with a quote from the English