Category: Research
A Circulating Inflammation Suppressor Decreases Mortality
February 19, 2026
Researchers publishing in Aging have used Mendelian randomization to conclude that the inflammatory factor IL6 causes increased mortality and that its circulating receptor, IL6R, decreases it. Looking for a proof
Lifetime Cognitive Enrichment Associated With Less Dementia
February 18, 2026
A recent study suggests that cognitive enrichment throughout life is associated with reduced dementia risk, and it has the potential to delay the onset of dementia and mild cognitive impairment
Silencing Growth Hormone Has Strong Effects in Mouse Brains
February 16, 2026
Researchers have found that altering a growth hormone receptor in the brain adipose tissue of aged male mice slows their mental aging and allows them to perform far better on
Cellular Reprogramming Rescues Memory-Encoding Neurons
February 13, 2026
Scientists have applied partial reprogramming to memory-encoding neurons (engrams) and achieved memory improvements in Alzheimer’s models and wild-type mice [1]. Rejuvenating neurons Partial cellular reprogramming, which uses certain factors to
Creating CAR-T Cells Using Current Alzheimer’s Antibodies
February 12, 2026
A team of researchers has biologically engineered T cells with currently available Alzheimer’s drugs in order to directly attack the characteristic amyloid plaques of Alzheimer’s disease. Building on the current
Young Microbes Rejuvenate Intestinal Function in Mice
February 11, 2026
Transferring microbiota from young to aged mice helped to restore molecular signaling necessary for proper intestinal function and improved the regenerative capacity of intestinal stem cells [1]. Everyday companions Bacteria,
Sleep Deprivation Affects Cognition via Myelin Loss
February 10, 2026
A new study links sleep loss to the thinning of the myelin layer, which slows signal transmission in axons. Restoring cholesterol homeostasis reverses the damage [1]. Sleep loss hurts myelin
Restoring the Strength of Natural Killer Cells
February 9, 2026
In Aging Cell, researchers have described why older natural killer (NK) cells lose their ability to eliminate harmful cells and a potential treatment for this decline. Judgment and ability At
Increasing Senolytic Effectiveness by Stressing Mitochondria
February 5, 2026
Researchers publishing in Nature Aging have described how mitochondrial stress is a key part of why senolytics are effective. Finding targeted effectiveness The researchers began this study by summarizing senescent
Association Between Vitamins and Slower Biological Aging
February 4, 2026
A recent study analyzed data from over 15,000 participants and their intake of 11 vitamins, and the results suggested that higher vitamin intake, particularly of Vitamins C and B2, is
Weight Training Load Doesn’t Affect Muscle Mass or Strength
February 3, 2026
A new study suggests that, if sets are taken close to failure, the amount of weight on the bar does not determine muscle growth. However, individual differences in muscle-building ability
CRISPR-Based Screen Reveals Possible Anti-Tau Mechanism
January 30, 2026
Using an ingenious CRISPR-based screening technique, scientists have found a protein that tags tau for degradation and is more strongly expressed in tau-resilient neurons [1]. Some neurons are more equal
Rejuve.AI Launches International Longevity Research Database
January 29, 2026
Roatán, Honduras — Rejuve.AI is activating the International Longevity Research Database (IRLDB) through its first real-world study cohort at the Longevity Biomarkers Competition and Summit, taking place February to March
Engineered Extracellular Vesicles Reduce Arrhythmia in Rats
January 29, 2026
In Nature Communications, researchers have described how small extracellular vesicles (sEVs) fused with plasma membrane proteins successfully treated heart arrhythmia in a rat model. Why do people need pacemakers? In
Shingles Vaccination Is Associated With Slower Aging
January 28, 2026
An analysis of over 3800 older adults found that shingles vaccination is associated with lower inflammation scores, slower epigenetic and transcriptomic aging, and a lower composite biological aging score [1].
A Circulating Inflammation Suppressor Decreases Mortality
February 19, 2026
Researchers publishing in Aging have used Mendelian randomization to conclude that the inflammatory factor IL6 causes increased mortality and that its circulating receptor, IL6R, decreases it. Looking for a proof of danger Chronic, age-related inflammation (inflammaging) is very well-known to be closely connected to negative age-related
Lifetime Cognitive Enrichment Associated With Less Dementia
February 18, 2026
A recent study suggests that cognitive enrichment throughout life is associated with reduced dementia risk, and it has the potential to delay the onset of dementia and mild cognitive impairment by five to seven years [1]. Cognitive stimulation Engagement in cognitively stimulating activities has been linked
Silencing Growth Hormone Has Strong Effects in Mouse Brains
February 16, 2026
Researchers have found that altering a growth hormone receptor in the brain adipose tissue of aged male mice slows their mental aging and allows them to perform far better on cognitive tests. Growth signaling is not necessarily good The axis of growth hormone and insulin-like growth
Cellular Reprogramming Rescues Memory-Encoding Neurons
February 13, 2026
Scientists have applied partial reprogramming to memory-encoding neurons (engrams) and achieved memory improvements in Alzheimer’s models and wild-type mice [1]. Rejuvenating neurons Partial cellular reprogramming, which uses certain factors to rejuvenate cells while maintaining their identity) has shown promise across various conditions and cell types, including
Creating CAR-T Cells Using Current Alzheimer’s Antibodies
February 12, 2026
A team of researchers has biologically engineered T cells with currently available Alzheimer’s drugs in order to directly attack the characteristic amyloid plaques of Alzheimer’s disease. Building on the current paradigm Most Alzheimer’s treatments used in the clinic are -mabs, monoclonal antibodies that are designed to
Young Microbes Rejuvenate Intestinal Function in Mice
February 11, 2026
Transferring microbiota from young to aged mice helped to restore molecular signaling necessary for proper intestinal function and improved the regenerative capacity of intestinal stem cells [1]. Everyday companions Bacteria, viruses, and other microbes are well-known as agents that cause disease and should be avoided. However,
Sleep Deprivation Affects Cognition via Myelin Loss
February 10, 2026
A new study links sleep loss to the thinning of the myelin layer, which slows signal transmission in axons. Restoring cholesterol homeostasis reverses the damage [1]. Sleep loss hurts myelin Sleep quality is a strong extrinsic determinant of longevity [2]. Not only does sleep loss affect
Restoring the Strength of Natural Killer Cells
February 9, 2026
In Aging Cell, researchers have described why older natural killer (NK) cells lose their ability to eliminate harmful cells and a potential treatment for this decline. Judgment and ability At the cellular level, there is no due process. Natural killer (NK) cells judge other cells’ guilt
Increasing Senolytic Effectiveness by Stressing Mitochondria
February 5, 2026
Researchers publishing in Nature Aging have described how mitochondrial stress is a key part of why senolytics are effective. Finding targeted effectiveness The researchers began this study by summarizing senescent cells and the senolytics created to eliminate them. They noted that few attempts have been made
Association Between Vitamins and Slower Biological Aging
February 4, 2026
A recent study analyzed data from over 15,000 participants and their intake of 11 vitamins, and the results suggested that higher vitamin intake, particularly of Vitamins C and B2, is associated with slower biological aging [1]. Beneficial molecules One of the easiest and most accessible ways
Weight Training Load Doesn’t Affect Muscle Mass or Strength
February 3, 2026
A new study suggests that, if sets are taken close to failure, the amount of weight on the bar does not determine muscle growth. However, individual differences in muscle-building ability appear to be real [1]. How should we train? Muscle mass and strength are among the
CRISPR-Based Screen Reveals Possible Anti-Tau Mechanism
January 30, 2026
Using an ingenious CRISPR-based screening technique, scientists have found a protein that tags tau for degradation and is more strongly expressed in tau-resilient neurons [1]. Some neurons are more equal than others The accumulation of tau protein fibrils in neurons is a hallmark of Alzheimer’s and
Rejuve.AI Launches International Longevity Research Database
January 29, 2026
Roatán, Honduras — Rejuve.AI is activating the International Longevity Research Database (IRLDB) through its first real-world study cohort at the Longevity Biomarkers Competition and Summit, taking place February to March 2026 as part of the Infinite Games in Roatán, Honduras. The IRLDB is being activated through
Engineered Extracellular Vesicles Reduce Arrhythmia in Rats
January 29, 2026
In Nature Communications, researchers have described how small extracellular vesicles (sEVs) fused with plasma membrane proteins successfully treated heart arrhythmia in a rat model. Why do people need pacemakers? In a healthy heart, the sinoatrial node (SAN) serves as a natural regulator, commanding the heart to
Shingles Vaccination Is Associated With Slower Aging
January 28, 2026
An analysis of over 3800 older adults found that shingles vaccination is associated with lower inflammation scores, slower epigenetic and transcriptomic aging, and a lower composite biological aging score [1]. Beneficial side effects Vaccines are developed to prevent specific diseases, such as polio, measles, hepatitis, and