Category: Research
Infrared Lasers Clear Harmful Compounds in Mouse Brains
October 16, 2025
Researchers have discovered that infrared lasers promote the clearance of toxic metabolites from the brains of age-accelerated mice by improving lymphatic drainage. Gunking up the works Advanced glycation end-products (AGEs),
Interventions Testing Program Finds Three New Compounds
October 15, 2025
A new report from the Interventions Testing Program adds three new compounds to the list of lifespan-extending compounds confirmed during their experiments: epicatechin, halofuginone, and mitoglitazone [1]. Rigorous testing The National
Why Naked Mole Rats Have Better DNA Repair
October 14, 2025
Scientists have found that the cGAS protein in naked mole rats, a famously long-lived species, boosts DNA repair, while the human version tends to hamper it. The difference boils down
Researchers Identify Key Age-Related Genes
October 13, 2025
In Aging Cell, researchers have described core genes that apply to a wide variety of species and appear to be causal drivers of aging. Looking for signals in the noise
Nanoparticles Potently Reverse Alzheimer’s in Mice
October 10, 2025
Scientists have created polymersomes, a type of nanoparticle, that latch onto a master regulator of amyloid-beta clearance, diverting it towards a more efficient route. The treatment drained Aβ from mouse
A Public Website for Evaluating Potential Anti-Aging Drugs
October 9, 2025
Researchers publishing in the International Journal of Molecular Sciences have showcased their creation of PASS GERO, a public-facing application that allows researchers to evaluate potential anti-aging compounds. Taking a PASS
Impact of Off-Label Low-Dose Rapamycin on Healthy Adults
October 8, 2025
A team of scientists has reviewed the clinical data regarding low-dose rapamycin therapy in healthy adults. They concluded that, while there is plenty of preclinical data regarding the impact of
Partial Reprogramming Enhances Nerve Repair in Rats
October 6, 2025
In Advanced Science, a team of researchers has explained how partial cellular reprogramming through the OSKM factors restores nerve repair ability to older animals. Stress as a signal This paper
Agentic AI Against Aging Hackathon
October 3, 2025
HackAging.ai is the global online hackathon at the intersection of Agentic AI and longevity science, bringing together researchers, founders, and engineers to accelerate solutions that extend healthy human lifespan. Turn
Joe Betts-Lacroix on Retro Bio and Its Recent AI Advancement
October 2, 2025
Retro Biosciences, one of the hottest startups in the longevity field, was founded about five years ago by the tech entrepreneur Joe Betts-Lacroix with a $180 million investment from his
Cell Cycle Stage Impacts the Efficacy of Senotherapeutics
October 1, 2025
A recent study reported that the effectiveness of the senotherapeutic drug ABT-263 depends on the cell’s DNA content, which is based on the cell cycle phase at which the senescent
Faulty Mitochondrial DNA Copying Might Cause Inflammaging
September 30, 2025
Scientists have discovered a possible mechanism behind age-related inflammation. It involves wrong building blocks being incorporated into mitochondrial DNA during replication and can be countered by adding the correct ones
A Combination Greatly Extends Lifespan in Male Mice
September 29, 2025
The Conboy lab in Berkeley has discovered a treatment combination that greatly extends lifespan in old male mice and published its findings in Aging. A combination with systemic effects The
New Universal Therapy Effective in Multiple Tumor Types
September 26, 2025
Scientists have reported a breakthrough in treating solid tumor cancers using a Velcro-like tool that targets glycans, surface sugars especially abundant in cancer cells. This potentially off-the-shelf therapy does not
A Potential Reason Why Clotting Increases With Age
September 25, 2025
In Aging Cell, researchers have described a method by which platelet-forming cells are rapidly generated from hematopoietic stem cells (HSCs), bypassing the intermediate cell types that are normally used to
Infrared Lasers Clear Harmful Compounds in Mouse Brains
October 16, 2025
Researchers have discovered that infrared lasers promote the clearance of toxic metabolites from the brains of age-accelerated mice by improving lymphatic drainage. Gunking up the works Advanced glycation end-products (AGEs), like their acronym suggests, accumulate with age. These substances, which are formed when sugars bind to
Interventions Testing Program Finds Three New Compounds
October 15, 2025
A new report from the Interventions Testing Program adds three new compounds to the list of lifespan-extending compounds confirmed during their experiments: epicatechin, halofuginone, and mitoglitazone [1]. Rigorous testing The National Institute on Aging’s Interventions Testing Program (ITP) is designed to rigorously test potential lifespan-extending compounds with
Why Naked Mole Rats Have Better DNA Repair
October 14, 2025
Scientists have found that the cGAS protein in naked mole rats, a famously long-lived species, boosts DNA repair, while the human version tends to hamper it. The difference boils down to just four amino acids [1]. DNA repair and cGAS Despite their unassuming appearance, naked mole
Researchers Identify Key Age-Related Genes
October 13, 2025
In Aging Cell, researchers have described core genes that apply to a wide variety of species and appear to be causal drivers of aging. Looking for signals in the noise Introducing their study, the researchers note that gene expression changes are difficult to interpret because they
Nanoparticles Potently Reverse Alzheimer’s in Mice
October 10, 2025
Scientists have created polymersomes, a type of nanoparticle, that latch onto a master regulator of amyloid-beta clearance, diverting it towards a more efficient route. The treatment drained Aβ from mouse brains within hours and, after a short dosing regimen, restored cognition to near wild-type levels [1].
A Public Website for Evaluating Potential Anti-Aging Drugs
October 9, 2025
Researchers publishing in the International Journal of Molecular Sciences have showcased their creation of PASS GERO, a public-facing application that allows researchers to evaluate potential anti-aging compounds. Taking a PASS at aging This paper begins with a discussion of how aging is currently treated, with a
Impact of Off-Label Low-Dose Rapamycin on Healthy Adults
October 8, 2025
A team of scientists has reviewed the clinical data regarding low-dose rapamycin therapy in healthy adults. They concluded that, while there is plenty of preclinical data regarding the impact of rapamycin, there is no sufficient evidence that low-dose rapamycin use can extend healthspan and lifespan in
Partial Reprogramming Enhances Nerve Repair in Rats
October 6, 2025
In Advanced Science, a team of researchers has explained how partial cellular reprogramming through the OSKM factors restores nerve repair ability to older animals. Stress as a signal This paper focuses on Schwann cells, glial cells that are often responsible for maintaining the protective sheaths of
Agentic AI Against Aging Hackathon
October 3, 2025
HackAging.ai is the global online hackathon at the intersection of Agentic AI and longevity science, bringing together researchers, founders, and engineers to accelerate solutions that extend healthy human lifespan. Turn two weeks into a job, a useful tool, a collaboration, or a company. The event is
Joe Betts-Lacroix on Retro Bio and Its Recent AI Advancement
October 2, 2025
Retro Biosciences, one of the hottest startups in the longevity field, was founded about five years ago by the tech entrepreneur Joe Betts-Lacroix with a $180 million investment from his friend Sam Altman, the CEO of OpenAI. Despite its hefty war chest, the company initially pursued
Cell Cycle Stage Impacts the Efficacy of Senotherapeutics
October 1, 2025
A recent study reported that the effectiveness of the senotherapeutic drug ABT-263 depends on the cell’s DNA content, which is based on the cell cycle phase at which the senescent cell was arrested [1]. A personalized approach Last week, we discussed clinical trials of senolytics and
Faulty Mitochondrial DNA Copying Might Cause Inflammaging
September 30, 2025
Scientists have discovered a possible mechanism behind age-related inflammation. It involves wrong building blocks being incorporated into mitochondrial DNA during replication and can be countered by adding the correct ones [1]. Too similar to bacteria Mitochondria, the cells’ energy-producing organelles, are considered to have developed from
A Combination Greatly Extends Lifespan in Male Mice
September 29, 2025
The Conboy lab in Berkeley has discovered a treatment combination that greatly extends lifespan in old male mice and published its findings in Aging. A combination with systemic effects The researchers begin this paper with a discussion of well-known interventions and their drawbacks. For example, they
New Universal Therapy Effective in Multiple Tumor Types
September 26, 2025
Scientists have reported a breakthrough in treating solid tumor cancers using a Velcro-like tool that targets glycans, surface sugars especially abundant in cancer cells. This potentially off-the-shelf therapy does not need adjustment to individual cancer types or patients. No sugarcoating this Antibody-based cancer immunotherapies, such as
A Potential Reason Why Clotting Increases With Age
September 25, 2025
In Aging Cell, researchers have described a method by which platelet-forming cells are rapidly generated from hematopoietic stem cells (HSCs), bypassing the intermediate cell types that are normally used to get there. Canonical and non-canonical formation It is well known that blood clots, which form when