Lifespan Research Institute

Matthew O'Connor

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Megaphone
The last installment in our end-of-year series of expert roundups might be the least flashy, but it is arguably no less important than the previous ones dedicated to longevity biotech and geroscience. Public advocacy is a powerful lever. To quote Abraham Lincoln: “Public sentiment is everything. With it, nothing can fail; against it, nothing can...
Women discussing options
A recent review of literature investigated the risks and benefits of hormone replacement therapy. The authors point out that this approach could be used as a geroprotector to extend the healthspan of women. However, the risk-benefit ratio should be individually evaluated. [1] Sex-specific aging trajectories Female and male aging trajectories differ, and one contributor is...
Biological research
2025 was a good year for geroscience, marked by rapid strides and critical milestones. Yet, the path wasn't always smooth: progress in some areas lagged, research hit dead ends, and familiar bottlenecks persisted. Against this backdrop, we asked five prominent geroscientists to share their perspectives on the highs and lows of 2025, along with their...
Human heart
Researchers publishing in Aging Cell have found that Hevin, a protein found in the extracellular matrix that increases with age, leads to heart problems in older male mice. Inflammaging contributes to heart disease Chronic InflammationChronic inflammation refers to a persistent, low-grade buzz of immune activity that settles into the body without the drama of an...
Arthritis
By inhibiting the aging-related enzyme 15-PGDH, scientists have shifted cartilage cells towards a healthier phenotype, leading to a significant improvement in a mouse model of osteoarthritis [1]. The hard-to-repair part Articular cartilage (the smooth, load-bearing cartilage on the ends of bones) doesn’t repair well with age or after injury [2], which is why osteoarthritis is...
RNA
In a paper published in Aging Cell, researchers have described how older cells send long interspersed nuclear element-1 (LINE-1) RNA to other cells in extracellular vesicles (EVs), spurring inflammation. Evil EVs In the literature, EVs are often discussed in a therapeutic context, as they can be used to send beneficial signals. However, EVs are the...