Lifespan Research Institute

Matthew O'Connor

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Joao Pedro de Magalhaes Interview
João Pedro de Magalhães, professor at the University of Birmingham, is known as a prominent geroscientist who has been in the field forever, enriching it with top-tier research. He is also a skilled longevity advocate who has long taken interest in the ethics of longevity, first offering his perspective as far back as 2003. Prof....
An analysis of over 800,000 women found no association between menopausal hormone therapy and increased mortality [1]. A controversial therapy One of the first major changes that women undergo as they age is menopause, which usually occurs between 45 and 55 years of age. Menopause not only marks the end of reproduction, the hormonal changes...
Fat cells
Scientists have discovered that, like brown fat, white fat has a mechanism that burns fuel to produce heat. This effect could potentially be used to create weight loss drugs [1]. Central heating Cells use energy to power various cellular processes, with heat being a byproduct. However, we might need additional heat to survive. Brown adipocytes...
Neuron
In Aging Cell, researchers have explained how the sirtuin SIRT6 protects against proteostasis-related brain disorders by maintaining the function of nucleoli and limiting protein production. The nucleus and nucleoli Loss of ProteostasisThe loss of proteostasis is the failure of the protein-building machinery of the cell and the accumulation of misfolded proteins, which is one of...
Robot diagnostics
A new system, which consists of a large LLM and a network of agentic tools, outperformed several other models and human physicians [1]. Too rare to easily diagnose Rare diseases can be notoriously hard to diagnose. Patients average over 5 years to receive a correct diagnosis, enduring repeated referrals, misdiagnoses, and unnecessary interventions in what...
Doctor holding heart model
Researchers publishing in Aging have used Mendelian randomization to conclude that the inflammatory factor IL6 causes increased mortality and that its circulating receptor, IL6R, decreases it. Looking for a proof of danger Chronic InflammationChronic inflammation refers to a persistent, low-grade buzz of immune activity that settles into the body without the drama of an infection...