Tag: Cartilage

Researchers have discovered that the osteoarthritis-inducing effects of excessive mechanical stress can be mitigated by increasing miR-330, a key regulator in cartilage and bone cells. Backbreaking labor is exactly that It has been long-held conventional wisdom that a lifetime of heavy physical labor leads to the early development of arthritis. This has been backed up...

By inhibiting the aging-related enzyme 15-PGDH, scientists have shifted cartilage cells towards a healthier phenotype, leading to a significant improvement in a mouse model of osteoarthritis [1]. The hard-to-repair part Articular cartilage (the smooth, load-bearing cartilage on the ends of bones) doesn’t repair well with age or after injury [2], which is why osteoarthritis is...

In the Journal of Nanobiotechnology, researchers have described a new method of delivering a long-lasting treatment into cartilage. A protein that promotes autophagy Previous work has linked expression of the FGF18 protein with healthy cartilage and joints [1]. Problems with the gene responsible for FGF18 lead to osteoarthritis [2], and it has been found to...

Publishing in Aging, a team of Spanish researchers has found that changing the mitochondria of standard Black 6 mice leads to marked improvements in joint health. Conplastic mice The Black 6 mouse is well-known in research as a standard in the industry. However, it is not nearly a perfect mouse in terms of ability or...

In a paper published in Nature Aging, a group of scientists outlines a previously unknown pathway that leads to osteoarthritis and describes a promising treatment [1]. Less than a killer, more than a nuisance There are plenty of deadly age-related diseases, and then there are others that shorten our healthspan rather than lifespan, making the...

Glucosamine and chondroitin are commonly bundled together as a dietary supplement, and a new study suggests that taking them may significantly reduce mortality. This builds on a previous epidemiological study from earlier this year, which showed that glucosamine supplementation correlates with reduced all-cause mortality. What are they? Glucosamine and chondroitin are both structural components of...