Tag: DNA Methylation

In a recent study, researchers have evaluated how responsive several DNA methylation (DNAm) biomarkers are to a range of longevity interventions [1]. Waiting too long Testing lifespan-extending interventions in humans has a major problem: it can take many years, or even decades, to see results. Nobody wants to wait that long. Therefore, it is essential...

In Aging Cell, researchers have reported that chromatin demethylation allows SASP compounds to be more easily expressed. Chromatin and gene expression Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially harmful chemical signals, collectively known...

A recent investigation into Hungarian Olympic champions suggests slower epigenetic aging and differences in gene methylation patterns between champions and non-champions [1]. Exercising your way to longevity Exercise seems to be the best lifestyle factor to slow aging and alleviates many aging-associated diseases and molecular changes. We have previously reported that exercise positively impacts cognition...

In Nature Communications, researchers have explained how epigenetic drift and disorder are associated with shorter lifespans across species. When randomness is a problem We have previously reported on research demonstrating that epigenetic clocks are most likely to be measuring noise. This paper builds on that concept, citing previous research showing that this gradual epigenetic drift...

The Journal Club returns on Friday October 27th at 11:30 am Eastern time on the Lifespan.io Facebook page.  We will be discussing the new paper from Conboy et al. which examines current DNA methylation clocks and their limitations in the context of aging. They also developed a "noise barometer" to measure the epigenetic impact of...

A group of researchers led by Morgan Levine of Altos Labs has created a set of methylation clocks that can detect various aging patterns [1]. The less-than-perfect revolution The discovery that genome methylation patterns correlate with various processes of aging led to the development of methylation (epigenetic) clocks. They first appeared more than a decade...