Tag: Inflammation

Researchers have found that bound pieces of RNA and DNA in the cytoplasm of senescent cells encourage these cells to secrete inflammatory factors. When transcription gets sticky As part of the transcription process that produces necessary proteins, RNA must chemically interact with DNA. When it binds to DNA and integrates itself into the genome, it...

Scientists have targeted the thin fat layer around blood vessels with a transcription inhibitor, reducing symptoms of cardiometabolic disease [1]. When vessels can’t “just relax” Cardiometabolic disease (CMD) – characterized, among other things, by obesity combined with high blood pressure – is one of the largest drivers of cardiovascular death [2]. It does its damage...

In Aging Cell, researchers have elucidated the relationship between intestinal aging and age-related changes to the gut microbiome. Two interdependent biologies The human gut works through the interaction of two entirely different sets of cells. The first is the body's actual cells, including the intestinal barrier between the gut and the rest of the body,...

An analysis of over 3800 older adults found that shingles vaccination is associated with lower inflammation scores, slower epigenetic and transcriptomic aging, and a lower composite biological aging score [1]. Beneficial side effects Vaccines are developed to prevent specific diseases, such as polio, measles, hepatitis, and many others. However, recent data suggest that some adult...

A review in Aging Cell has cataloged the harmful effects of EDA2R, a protein that affects three distinct inflammation-related pathways. A necessary protein gone bad Like nearly every other protein with documented harmful effects, this one is required for certain systems to function properly. The EDA gene is needed for proper skin development [1] and...

In Cell Reports Medicine, researchers have published a detailed review on the relationship between cardiovascular disease and the age-related inflammation known as inflammaging. The immune system itself ages Chronic InflammationChronic inflammation refers to a persistent, low-grade buzz of immune activity that settles into the body without the drama of an infection or obvious injury. In...