Tag: Spinal Discs

In Aging Cell, a team of researchers has described how a little-known gene, ZNF865, has a significant influence on back pain through the regulation of cellular senescence. Lower back pain and senescence are related Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of...

Researchers publishing in Aging Cell have discovered that using FGF21 to upregulate the sirtuin SIRT1 delays spinal disc degeneration in a rat model. A common cause of lower back problems Intervertebral disc degeneration (IDD) is one of the core reasons for lower back pain in older people. This nearly ubiquitous problem is a frequent target...

Researchers have tested a synthetic and natural senolytic combination of RG-7112 and o-vanillin in mice with early-onset low back pain and disc degeneration. They observed reduced signs of back pain; decreased senescence and disc degeneration; and improvements in vertebral bone quality [1]. A painful global problem Globally, low back pain is responsible for the most...

A new paper published in the Nature journal Bone Research has found that reprogramming the epigenetics of spinal disc cells reduces senescence and alleviates pain in a rat model. The soft tissue degrades Nucleus pulposus cells, which maintain the discs in the spine [1], are prone to the same age-related deterioration that other cells are....

Researchers have found a new avenue for approaching spinal disc degeneration and published their work in Aging Cell. A very common problem Back problems in the elderly are widely known to be caused by a deteriorating spine. Some of these problems are due to the vertebrae themselves losing cohesion, such as in osteoporosis, but the...

In Aging Cell, researchers have published a potential method of ameliorating disc degeneration that focuses on the cells living in a low-oxygen environment within the discs. Living on low oxygen Yesterday, we discussed how an antioxidant compound was found to alleviate intervertebral disk degeneration (IVDD). This related paper focuses on a tissue that is already...