Researchers publishing in Aging Cell have found that Hevin, a protein found in the extracellular matrix that increases with age, […]
By inhibiting the aging-related enzyme 15-PGDH, scientists have shifted cartilage cells towards a healthier phenotype, leading to a significant improvement in a mouse model of osteoarthritis [1]. The hard-to-repair part Articular cartilage (the […]
In a paper published in Aging Cell, researchers have described how older cells send long interspersed nuclear element-1 (LINE-1) RNA to other cells in extracellular […]
A recent study investigated biomarkers that can help monitor trajectories of Alzheimer’s disease-related molecular processes, such as neuronal cell death, and how patients respond to treatments. The authors reported […]
How did the year 2025 turn out for longevity biotech? Was it surprising or more of the same? Exciting or disappointing? Was the progress fast-moving or […]
Scientists have found that a single microbial species can blunt the negative effects of a high-fat diet due to the unique mix of lipids it produces [1]. They intend to identify its specific lipids in future work. Good […]
We’re closer to 2050 than to 2000, and technology is advancing apace; this includes technologies that help us stop aging in all its forms. Here’s […]
Longevity Investors announces the upcoming Longevity Investors Lunch 2026, an exclusive, application-only gathering designed specifically for investors seeking exposure to the most compelling opportunities emerging at […]
A recent review evaluated studies that included over 5.5 million participants to assess the impact of multivitamin and mineral supplements on different aspects of health […]
Scientists in Japan have discovered that multiple strains of bacteria taken from frogs, newts, and lizards can be effective against human colon […]
In Aging Cell, researchers have identified bone marrow stromal antigen 2 (BST2) as a key protein in age-related hearing loss in a […]
A new study proposes a novel approach to fighting immune system decline caused by thymic involution: making the liver produce proteins that support T cell development […]
Dr. Maximina Yun, principal investigator at Chinese Institutes for Medical Research in Beijing (CIMR), studies some of the most amazing animals in the world: salamanders, a group of amphibians that includes newts and […]
Why do we age at all, and why do different species age at such dramatically different rates? After decades of longevity research, biologists still disagree on the most basic questions: What is aging? Is it possible to stop or […]
In Nature Aging, researchers have discovered growth differentiation factor 3 (GDF3), a cytokine that increases with aging, is related to more inflammatory macrophages in older animals. Fat and inflammation We have recently reported […]
Researchers have investigated the reporting quality of preclinical studies’ outcomes in anti-aging research. They analyzed how study quality changed over time, shortcomings in […]
Scientists have investigated a little-known mechanism that fuels cellular senescence: mitochondrial RNA leaking into the cytoplasm. Targeting this mechanism showed promise in a mouse model of fatty liver [1]. […]
In Aging, researchers have described how they removed visceral fat from older male mice by targeting the metabolic regulatory protein CD47. A key regulator of metabolism Visible fat carried around the body is subcutaneous fat. While this […]
A new observational study spanning two human cohorts has found a link between theobromine, a phytochemical abundant in cocoa, and […]
Comparison of human umbilical cord blood with adult plasma revealed hundreds of metabolites whose abundances were age-dependent. Two different formulas, each a mix of a few metabolites, demonstrated anti-senescence […]
Happy holidays! Winter is in full swing for those of us in the Northern Hemisphere. It is a time for cozy nights by the fire and a great time to catch up […]
In Aging Cell, researchers have described how an age-related deficiency in another compound leads the antioxidant FoxO1 to contribute to bone deterioration in osteoporosis by siphoning from a […]
In a new study, extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) improved spatial working memory in rhesus macaques, suggesting a […]
Researchers have discovered that extracellular vesicles (EVs) derived from the nasal mucosa provide significant regenerative benefits to tissues throughout the body, including the brain. […]
A new review highlights the promise of microglia replacement, a strategy that made the leap from mouse studies to the first successful human trial in just five years [1]. Repair or replace Microglia, the resident […]
In Nature Aging, researchers have published their finding that targeting urokinase plasminogen activator receptor (uPAR), a senescence-associated protein, restores gut function in mice. One way the […]
A recent study investigated plasma proteins in people exposed to secondhand smoke and found that exposure affected multiple molecular processes, including immune, inflammatory, and tissue repair pathways [1]. Carrying the consequences of something you didn’t do It is widely known […]
In a new study, the amino acid arginine shows promise in animal models of amyloid aggregation due to its ability to promote protein folding. The researchers suggest that it […]
Many researchers in the United States have finished eating turkey and begun shopping, but their work continues. Here’s what people around the world have been doing to fight aging in November. […]
Scientists have discovered that a cytotoxic subtype of CD4 T cells, which is enriched in old people, helps control cellular senescence. This hints at a new type […]
