Category: News
AI Model Accurately Predicts Multiple Disease Risks
September 22, 2025
European scientists have created a GPT-based model that can predict the risk of more than a thousand diseases on par with single-disease tools and biomarker-based models [1]. Tell me the
Lipid Metabolism Is Causal in Some Alzheimer’s Cases
September 19, 2025
In Aging Cell, researchers have outlined the relationship between Alzheimer’s, increased pain sensitivity, and the enzyme LPCAT2. Pain is among the earliest signs The key characteristics of Alzheimer’s disease, such
Looking Back at Summer, Looking Forward to Growth
September 18, 2025
For those of us in the Northern Hemisphere, autumn is underway. The fall is a time when the leaves that are green turn to brown, so let us see what
Partial Reprogramming Rejuvenates Aged Cells and Tissues
September 17, 2025
In a recent study, researchers investigated aging- and disease-associated changes in gene expression related to epithelial-mesenchymal transition. Inducing the Yamanaka factors in mice allowed them to rejuvenate cells and tissues
A Short-Term High-Fat Diet Harms Memory in Mice
September 16, 2025
Scientists have demonstrated that even two days on a Western-like high-fat diet reduce hippocampal glucose availability, which activates a subset of inhibitory neurons and causes memory problems in mice [1].
How Macrophages Manage Obesity and Change With Age
September 15, 2025
In Nature Aging, researchers have identified and categorized several macrophage subtypes, including a subtype that appears with aging and another that manages nerve function. Not all macrophages follow the same
Microplastics Cause Cognitive Deficits in APOE4 Mice
September 12, 2025
Scientists have demonstrated that short-term exposure to microplastics causes Alzheimer’s-like effects in mice expressing human APOE4 versus APOE3. These effects were sex-dependent, mirroring the disease in humans [1]. Microplastics and
Epigenetic Clocks Do Not Perfectly Capture Metabolic Health
September 11, 2025
In Aging Cell, researchers have published their surprising findings that epigenetic clocks are not significantly related to most measurements of metabolic health after weight loss interventions. The utility of clocks
Regular Glucosamine Use Linked to Fewer Chronic Diseases
September 10, 2025
An analysis of UK Biobank data showed an association between regular glucosamine use and significantly lower risks of seven non-communicable chronic diseases [1]. A common supplement Glucosamine, a sugar molecule
Microglial Aging Is Determined by Their Environment
September 9, 2025
A new preprint study from Calico has found that the local brain environment is the primary driver of microglial aging. After being transplanted into old brains, young cells adopted aged
Study Boosts Brain Mitochondria, Rescues Memory in Mice
September 8, 2025
Scientists have found a way to directly stimulate the assembly of Complex I in mitochondria, rescuing memory deficits in mouse models of Alzheimer’s and frontotemporal dementia [1]. Mitochondrial signal transducers
A Mechanism Behind Protein Aggregation Discovered
September 5, 2025
Scientists have found a pathway that regulates protein aggregation, a cause of several age-related neurodegenerative diseases. United by abnormal protein aggregation Most neurodegenerative diseases are age-related, and many of them
Some Bioethicists Promote Lifespan Limitation
September 4, 2025
A paper published in Bioethics makes a startling case for people to die at 100 years old rather than live as long as they might choose. Deathism is relatively rare
Cancer Cells Transfer Mitochondria to Fibroblasts
September 3, 2025
Scientists have discovered that cancer cells recruit fibroblasts to support tumor growth by transferring mitochondria into them. Blocking this process might be a new way to fight the deadly disease
A Non-Viral Gene Therapy Restores Mouse Hearts
September 3, 2025
A recent study investigated the roles of brown adipose tissue and a lipid-controlling hormone, 12,13-diHOME, in cardiac health. The researchers examined the molecular mechanisms behind 12,13-diHOME’s effects on the hearts
AI Model Accurately Predicts Multiple Disease Risks
September 22, 2025
European scientists have created a GPT-based model that can predict the risk of more than a thousand diseases on par with single-disease tools and biomarker-based models [1]. Tell me the future! For millennia, people have wanted to know what health events await them in the future.
Lipid Metabolism Is Causal in Some Alzheimer’s Cases
September 19, 2025
In Aging Cell, researchers have outlined the relationship between Alzheimer’s, increased pain sensitivity, and the enzyme LPCAT2. Pain is among the earliest signs The key characteristics of Alzheimer’s disease, such as cognitive decline and brain deterioration, are very well-known [1]. However, other symptoms, such as pain
Looking Back at Summer, Looking Forward to Growth
September 18, 2025
For those of us in the Northern Hemisphere, autumn is underway. The fall is a time when the leaves that are green turn to brown, so let us see what the Lifespan team has been working on to help our field keep our own metaphorical leaves
Partial Reprogramming Rejuvenates Aged Cells and Tissues
September 17, 2025
In a recent study, researchers investigated aging- and disease-associated changes in gene expression related to epithelial-mesenchymal transition. Inducing the Yamanaka factors in mice allowed them to rejuvenate cells and tissues and reverse some of these aging-associated changes [1]. Rejuvenating cellular identity Aging-related epigenetic changes result in
A Short-Term High-Fat Diet Harms Memory in Mice
September 16, 2025
Scientists have demonstrated that even two days on a Western-like high-fat diet reduce hippocampal glucose availability, which activates a subset of inhibitory neurons and causes memory problems in mice [1]. Is it OK to eat junk occasionally? Metabolic disease and obesity are known to harm cognitive
How Macrophages Manage Obesity and Change With Age
September 15, 2025
In Nature Aging, researchers have identified and categorized several macrophage subtypes, including a subtype that appears with aging and another that manages nerve function. Not all macrophages follow the same rules Macrophages declining with age is a well-known problem, and many proposed solutions involve changing their
Microplastics Cause Cognitive Deficits in APOE4 Mice
September 12, 2025
Scientists have demonstrated that short-term exposure to microplastics causes Alzheimer’s-like effects in mice expressing human APOE4 versus APOE3. These effects were sex-dependent, mirroring the disease in humans [1]. Microplastics and the brain Exposure to tiny particles that plastic products shed (microplastics) has been linked to increased
Epigenetic Clocks Do Not Perfectly Capture Metabolic Health
September 11, 2025
In Aging Cell, researchers have published their surprising findings that epigenetic clocks are not significantly related to most measurements of metabolic health after weight loss interventions. The utility of clocks These researchers begin by discussing epigenetic clocks and how much the measured alterations in gene expression
Regular Glucosamine Use Linked to Fewer Chronic Diseases
September 10, 2025
An analysis of UK Biobank data showed an association between regular glucosamine use and significantly lower risks of seven non-communicable chronic diseases [1]. A common supplement Glucosamine, a sugar molecule with an amine group (amino sugar), is a supplement used by almost 20% of middle-aged adults
Microglial Aging Is Determined by Their Environment
September 9, 2025
A new preprint study from Calico has found that the local brain environment is the primary driver of microglial aging. After being transplanted into old brains, young cells adopted aged characteristics, but their susceptibility to these signals could be turned off [1]. Microglia grow old and
Study Boosts Brain Mitochondria, Rescues Memory in Mice
September 8, 2025
Scientists have found a way to directly stimulate the assembly of Complex I in mitochondria, rescuing memory deficits in mouse models of Alzheimer’s and frontotemporal dementia [1]. Mitochondrial signal transducers Many neurodegenerative diseases, such as Alzheimer’s disease, are associated with mitochondrial dysfunction [2], which might lead
A Mechanism Behind Protein Aggregation Discovered
September 5, 2025
Scientists have found a pathway that regulates protein aggregation, a cause of several age-related neurodegenerative diseases. United by abnormal protein aggregation Most neurodegenerative diseases are age-related, and many of them are similar in other ways. For instance, amyotrophic lateral sclerosis (ALS), Huntington’s disease, and Alzheimer’s disease
Some Bioethicists Promote Lifespan Limitation
September 4, 2025
A paper published in Bioethics makes a startling case for people to die at 100 years old rather than live as long as they might choose. Deathism is relatively rare People who wholeheartedly believe that human lifespans should be restricted to a pre-defined span are not
Cancer Cells Transfer Mitochondria to Fibroblasts
September 3, 2025
Scientists have discovered that cancer cells recruit fibroblasts to support tumor growth by transferring mitochondria into them. Blocking this process might be a new way to fight the deadly disease [1]. It goes both ways Cancer doesn’t act alone. Its success often hinges on recruiting neighboring
A Non-Viral Gene Therapy Restores Mouse Hearts
September 3, 2025
A recent study investigated the roles of brown adipose tissue and a lipid-controlling hormone, 12,13-diHOME, in cardiac health. The researchers examined the molecular mechanisms behind 12,13-diHOME’s effects on the hearts of aged mice [1]. The aging heart Aging leads to many cardiovascular system-related changes, which are