Category: News
A Senescence-Related Target for Blood Vessel Formation
April 21, 2025
In Aging Cell, researchers have linked macrophage senescence to the failure of new blood vessel formation, finding a key target that might make it easier to treat arterial clogs. Macrophages
Researchers Use Big Data to Find a Longevity Target
April 16, 2025
Researchers publishing in Aging Cell have used large databases to discover a causal relationship between multiple genes and overall mortality risk, finding a new potential target in the process. Putting
Senolytics Decrease Low Back Pain in Mice
April 15, 2025
Researchers have tested a synthetic and natural senolytic combination of RG-7112 and o-vanillin in mice with early-onset low back pain and disc degeneration. They observed reduced signs of back pain;
Results of a Crowdfunded One-Year Human Rapamycin Trial
April 14, 2025
In Aging, Dr. Sajid Zalzala and his team have published the results of Participatory Evaluation of Aging with Rapamycin for Longevity (PEARL), a randomized, controlled human clinical trial that was
Neurons Hidden to Immune Cells Improve Parkinson’s in Rats
April 11, 2025
By tweaking genes used by placental and cancerous cells to evade immune detection, scientists have created non-immunogenic neuronal grafts that may help Parkinson’s patients [1]. Sneakiness needed In recent years,
How Exercise May Fight Parkinson’s Disease
April 10, 2025
Experimenting on rodents, researchers have found a pathway through which exercise could fight Parkinson’s disease and a molecule that might recapitulate this effect. Fighting inflammation is crucial in Parkinson’s Parkinson’s
Dietary Patterns Associated With Healthy Aging
April 9, 2025
A recent study investigated the impact of eight different mid-life dietary patterns on the odds of healthy aging, including cognitive, mental, and physical health [1]. You are what you eat
Fasting Affects the Immune System via the Brain
April 8, 2025
A new study has found that the immune remodeling associated with fasting can be recapitulated by activating a subset of neurons in the hypothalamus. The findings could be important in
Reprogramming Epigenetics to Fight Back Pain
April 7, 2025
A new paper published in the Nature journal Bone Research has found that reprogramming the epigenetics of spinal disc cells reduces senescence and alleviates pain in a rat model. The
World’s First Pig-to-Human Liver Transplant
April 4, 2025
Chinese scientists announced the world’s first successful transplantation of a genetically modified pig liver into a brain-dead patient. This represents an important step towards routinely using pig organs to save
Extracellular Vesicles Restore Some Heart Function to Mice
April 3, 2025
Publishing in Stem Cell Research & Therapy, researchers have found that small extracellular vesicles (sEVs) derived from young mice alleviate heart dysfunction in older mice. Reaffirming an approach These researchers
Activation of Silent X Chromosome Might Improve Cognition
April 2, 2025
Using a mouse model, researchers from UCSF have found that the genes that become activated on the silent X chromosome might explain some sex-dependent differences in cognitive abilities during aging
Scientists Discover a New Mitigator of Senescence
April 1, 2025
Working with flies, mice, and human cells, scientists have demonstrated that a highly conserved protein can modulate cellular senescence, potentially opening a new avenue for future therapies [1]. DNA damage
Rejuvenation Roundup March 2025
April 1, 2025
It’s April Fool’s Day, but until we prevent our bodies from gradually deteriorating, the joke will always be on us. Here’s a no-fooling list of what’s been done to fight
Changes in Aging Adrenal Glands Disturb Hormonal Balance
March 31, 2025
In the Journal of Endocrinological Investigation, reviewers have described how aging affects the adrenal glands, which has downstream effects on the rest of the human body. Small but vital This
A Senescence-Related Target for Blood Vessel Formation
April 21, 2025
In Aging Cell, researchers have linked macrophage senescence to the failure of new blood vessel formation, finding a key target that might make it easier to treat arterial clogs. Macrophages can impair blood vessel formation Heart attack and stroke are not the only problems caused by
Researchers Use Big Data to Find a Longevity Target
April 16, 2025
Researchers publishing in Aging Cell have used large databases to discover a causal relationship between multiple genes and overall mortality risk, finding a new potential target in the process. Putting -omics databases to work These researchers introduce their study by discussing genetic databases, which have previously
Senolytics Decrease Low Back Pain in Mice
April 15, 2025
Researchers have tested a synthetic and natural senolytic combination of RG-7112 and o-vanillin in mice with early-onset low back pain and disc degeneration. They observed reduced signs of back pain; decreased senescence and disc degeneration; and improvements in vertebral bone quality [1]. A painful global problem
Results of a Crowdfunded One-Year Human Rapamycin Trial
April 14, 2025
In Aging, Dr. Sajid Zalzala and his team have published the results of Participatory Evaluation of Aging with Rapamycin for Longevity (PEARL), a randomized, controlled human clinical trial that was crowdfunded by lifespan.io. Crowdfunded research bears fruit Four years ago, in collaboration with AgelessRx, lifespan.io crowdfunded
Neurons Hidden to Immune Cells Improve Parkinson’s in Rats
April 11, 2025
By tweaking genes used by placental and cancerous cells to evade immune detection, scientists have created non-immunogenic neuronal grafts that may help Parkinson’s patients [1]. Sneakiness needed In recent years, scientists have learned to produce cells via cellular reprogramming, a process in which differentiated cells are
How Exercise May Fight Parkinson’s Disease
April 10, 2025
Experimenting on rodents, researchers have found a pathway through which exercise could fight Parkinson’s disease and a molecule that might recapitulate this effect. Fighting inflammation is crucial in Parkinson’s Parkinson’s disease is characterized by Lewy bodies and the loss of dopaminergic neurons [1]. Recent work has
Dietary Patterns Associated With Healthy Aging
April 9, 2025
A recent study investigated the impact of eight different mid-life dietary patterns on the odds of healthy aging, including cognitive, mental, and physical health [1]. You are what you eat Diet is an easily modifiable intervention in aging, as what we eat has a tremendous impact
Fasting Affects the Immune System via the Brain
April 8, 2025
A new study has found that the immune remodeling associated with fasting can be recapitulated by activating a subset of neurons in the hypothalamus. The findings could be important in the context of fasting mimicking, metabolic disorders, and cancer [1]. Fasting and the immune system Decades
Reprogramming Epigenetics to Fight Back Pain
April 7, 2025
A new paper published in the Nature journal Bone Research has found that reprogramming the epigenetics of spinal disc cells reduces senescence and alleviates pain in a rat model. The soft tissue degrades Nucleus pulposus cells, which maintain the discs in the spine [1], are prone
World’s First Pig-to-Human Liver Transplant
April 4, 2025
Chinese scientists announced the world’s first successful transplantation of a genetically modified pig liver into a brain-dead patient. This represents an important step towards routinely using pig organs to save human lives [1]. Where do we get spare parts? The shortage of organs for transplantation is
Extracellular Vesicles Restore Some Heart Function to Mice
April 3, 2025
Publishing in Stem Cell Research & Therapy, researchers have found that small extracellular vesicles (sEVs) derived from young mice alleviate heart dysfunction in older mice. Reaffirming an approach These researchers note that there are a few ways to classify extracellular vesicles. Many of the earlier classifications
Activation of Silent X Chromosome Might Improve Cognition
April 2, 2025
Using a mouse model, researchers from UCSF have found that the genes that become activated on the silent X chromosome might explain some sex-dependent differences in cognitive abilities during aging [1]. XX and XY It is widely known that women live longer than men [2]. Women
Scientists Discover a New Mitigator of Senescence
April 1, 2025
Working with flies, mice, and human cells, scientists have demonstrated that a highly conserved protein can modulate cellular senescence, potentially opening a new avenue for future therapies [1]. DNA damage and senescence Imagine what would happen if the computer code in the software we use daily
Rejuvenation Roundup March 2025
April 1, 2025
It’s April Fool’s Day, but until we prevent our bodies from gradually deteriorating, the joke will always be on us. Here’s a no-fooling list of what’s been done to fight aging last month. Interviews Joshua “Scotch” McClure: “Infectious Disease Drives Aging”: According to McClure, his company’s
Changes in Aging Adrenal Glands Disturb Hormonal Balance
March 31, 2025
In the Journal of Endocrinological Investigation, reviewers have described how aging affects the adrenal glands, which has downstream effects on the rest of the human body. Small but vital This paper begins with an in-depth description of the anatomy of the adrenal glands, which sit atop