Category: News
Rejuvenation Roundup April 2022
May 2, 2022
April showers bring May flowers, and we’ve got a shower of interviews, new research, and press releases this month. Here’s what’s happened in rejuvenation in April. LEAF News Lifespan Docs:
Cellular Reprogramming Boosts Liver Regeneration in Mice
April 29, 2022
Scientists have shown that partial cellular reprogramming can significantly increase the already impressive regenerative capacity of the liver and protect this crucial organ from a potentially lethal injury [1]. Why
Synergy Between Stem Cell Rejuvenation and Senolytics
April 28, 2022
In a preprint published in bioRxiv, a team of Singaporean researchers, including Jan Gruber, has found that a combination of stem cell rejuvenation and senescent cell removal is synergistically more
An Epigenetic Clock for Brain Age and Alzheimer’s Disease
April 27, 2022
The risk of Alzheimer’s disease goes up with age, and the number of people living with Alzheimer’s is growing. While it is known to be associated with the loss of
Early Life Rapamycin Treatment Effective in Flies and Mice
April 26, 2022
In a preprint paper, scientists have shown that treating drosophila flies and mice with rapamycin for a relatively brief period in early life mostly recapitulates the effects of a lifelong
A Genetic Analysis of Chronic Inflammation
April 25, 2022
Nature Communications has recently published a paper discussing the genetic sources of C-reactive protein, a well-known biomarker of chronic inflammation. An extremely broad study with a wide variety of genes
Plastic Nanoparticles in Cellular Senescence and Dysfunction
April 22, 2022
Scientists have found that exposure to plastic nanoparticles drives cellular senescence and dysfunction in endothelial cells taken from a pig’s coronary artery [1]. A widespread pollutant Plastic has changed the
Combining Caloric Restriction and Rapamycin
April 21, 2022
A new study published in Nature Communications has found that rapamycin, which is often considered to be a calorie restriction mimetic, has different and additive effects to caloric restriction in
Discussing Low-Dose Naltrexone with Sajad Zalzala
April 20, 2022
Dr. Sajad Zalzala, co-founder of AgelessRx, prescribes naltrexone for a variety of conditions and is currently enrolling patients in clinical trials for its effectiveness against the lingering effects of COVID-19
Toll-like Receptor Deletion Improves Memory in Aged Mice
April 19, 2022
In a new study, genetic deletion of the TLR4 receptor ameliorated aspects of age-related cognitive decline in naturally aging mice, probably due to decreased inflammation [1]. Taking a toll as
Small Molecule Protects Against Oxidative Aging in Egg Cells
April 18, 2022
A group of researchers has documented in Aging that Epitalon, a synthetic peptide made of four amino acids, slows the aging of egg cells (oocytes) after ovulation. Aging makes fertilization
Mutation Burden Explains Species’ Differences in Lifespan
April 15, 2022
In a study published in Nature, scientists have found an extremely strong correlation between somatic mutation rate and lifespan across several species, highlighting the importance of mutation burden for aging
Fundamental Protein Regulator Increases Lifespan in Flies
April 14, 2022
Increasing an important protein regulator improves the lifespan of Drosophila flies, according to a new paper published in Aging. Found in both animals and plants As the researchers explain, phosphatidylethanolamine-binding
One Cycle of Partial Reprogramming for Tissue Rejuvenation
April 13, 2022
Scientists have shown that a single cycle of partial cellular reprogramming leads to various changes in the tissues, but about half of them gradually disappear after the treatment [1]. Permanent
Dr. Steven Austad on Aging in Wild and Lab Animals
April 12, 2022
Dr. Steven Austad of the University of Alabama at Birmingham is not a typical geroscientist, or at least, he did not become one in a typical way. After obtaining his undergraduate
Rejuvenation Roundup April 2022
May 2, 2022
April showers bring May flowers, and we’ve got a shower of interviews, new research, and press releases this month. Here’s what’s happened in rejuvenation in April. LEAF News Lifespan Docs: Doug Vakoch of METI: Created by Tim Maupin and sponsored by lifespan.io, this Lifespan Docs documentary
Cellular Reprogramming Boosts Liver Regeneration in Mice
April 29, 2022
Scientists have shown that partial cellular reprogramming can significantly increase the already impressive regenerative capacity of the liver and protect this crucial organ from a potentially lethal injury [1]. Why can’t we regrow limbs? Cellular reprogramming induces de-differentiation of somatic cells back into pluripotent stem cells:
Synergy Between Stem Cell Rejuvenation and Senolytics
April 28, 2022
In a preprint published in bioRxiv, a team of Singaporean researchers, including Jan Gruber, has found that a combination of stem cell rejuvenation and senescent cell removal is synergistically more effective than either alone. Different but related aspects of aging The researchers begin this paper by
An Epigenetic Clock for Brain Age and Alzheimer’s Disease
April 27, 2022
The risk of Alzheimer’s disease goes up with age, and the number of people living with Alzheimer’s is growing. While it is known to be associated with the loss of proteostasis, it has also been found to be associated with epigenetic alterations. An advanced online preprint
Early Life Rapamycin Treatment Effective in Flies and Mice
April 26, 2022
In a preprint paper, scientists have shown that treating drosophila flies and mice with rapamycin for a relatively brief period in early life mostly recapitulates the effects of a lifelong treatment, including lifespan extension in flies [1]. Rapamycin is considered one of the most promising geroprotective
A Genetic Analysis of Chronic Inflammation
April 25, 2022
Nature Communications has recently published a paper discussing the genetic sources of C-reactive protein, a well-known biomarker of chronic inflammation. An extremely broad study with a wide variety of genes Pulling genomic data from 427,367 participants in the UK Biobank and 148,164 people from the Cohorts
Plastic Nanoparticles in Cellular Senescence and Dysfunction
April 22, 2022
Scientists have found that exposure to plastic nanoparticles drives cellular senescence and dysfunction in endothelial cells taken from a pig’s coronary artery [1]. A widespread pollutant Plastic has changed the face of civilization, but the convenience of plastic comes at a price – mostly in terms
Combining Caloric Restriction and Rapamycin
April 21, 2022
A new study published in Nature Communications has found that rapamycin, which is often considered to be a calorie restriction mimetic, has different and additive effects to caloric restriction in muscle tissue. The role of mTORC1 Mammalian target of rapamycin complex 1 (mTORC1) is a well-known
Discussing Low-Dose Naltrexone with Sajad Zalzala
April 20, 2022
Dr. Sajad Zalzala, co-founder of AgelessRx, prescribes naltrexone for a variety of conditions and is currently enrolling patients in clinical trials for its effectiveness against the lingering effects of COVID-19 as well as for longevity. We caught up with him to discuss the progress in this
Toll-like Receptor Deletion Improves Memory in Aged Mice
April 19, 2022
In a new study, genetic deletion of the TLR4 receptor ameliorated aspects of age-related cognitive decline in naturally aging mice, probably due to decreased inflammation [1]. Taking a toll as we age Toll-like receptor 4 (TLR4) is a member of an ancient, highly evolutionary conserved family
Small Molecule Protects Against Oxidative Aging in Egg Cells
April 18, 2022
A group of researchers has documented in Aging that Epitalon, a synthetic peptide made of four amino acids, slows the aging of egg cells (oocytes) after ovulation. Aging makes fertilization difficult Oocyte aging is well-known to lead to fertilization deficiencies and a host of other problems
Mutation Burden Explains Species’ Differences in Lifespan
April 15, 2022
In a study published in Nature, scientists have found an extremely strong correlation between somatic mutation rate and lifespan across several species, highlighting the importance of mutation burden for aging [1]. The question of why lifespan varies so vastly among species, including closely related ones, has
Fundamental Protein Regulator Increases Lifespan in Flies
April 14, 2022
Increasing an important protein regulator improves the lifespan of Drosophila flies, according to a new paper published in Aging. Found in both animals and plants As the researchers explain, phosphatidylethanolamine-binding proteins (PEBPs) are present in both plant and animal cells. These proteins are critical to multiple
One Cycle of Partial Reprogramming for Tissue Rejuvenation
April 13, 2022
Scientists have shown that a single cycle of partial cellular reprogramming leads to various changes in the tissues, but about half of them gradually disappear after the treatment [1]. Permanent or transient? It has been known since 2006 that somatic cells can be reverted to a
Dr. Steven Austad on Aging in Wild and Lab Animals
April 12, 2022
Dr. Steven Austad of the University of Alabama at Birmingham is not a typical geroscientist, or at least, he did not become one in a typical way. After obtaining his undergraduate degree in English literature, Steven spent several years on jobs such as a wild animal trainer