Category: News
Collagen, Senescence, and Age-Related Hair Loss
August 25, 2021
Last week, a new study published in Aging reported similar mechanisms of TGF-ß2 and collagen on hair follicle aging, dermal papilla cell senescence, and in vitro spheroid formation. Aging hair
Working the Deletion Problem out of CRISPR
August 24, 2021
In a study published in Genome Biology, researchers explain how they are working to make CRISPR less prone to large, accidental deletions of genetic material [1]. A previously unknown large
Stress, Sensory Gating, and Cognitive Decline With Age
August 23, 2021
Researchers publishing in Aging have found that stresses, both biological and in daily life, harm one of our fundamental abilities to correctly process what’s going on around us. What is
Longeveron Takes Aim at Aging with Cell Therapy
August 18, 2021
Longeveron has just announced the first data from its Phase 2b clinical trial that targets frailty with Lomecel-B, an MSC-based cell therapy. A longevity strategy built in More and more,
The Hedgehog Protein Reduces Microglial Inflammation in Mice
August 17, 2021
Researchers, publishing in the journal Aging, have discovered that a protein called hedgehog alleviates the tissue-specific, age-related inflammation of the microglia, the maintenance cells of the brain. The aging differences
Stem Cell Helper Heat Shock Protein Identified
August 16, 2021
Researchers publishing in Cell Stem Cell have identified a protein that helps hematopoietic stem cells (HSCs) both in ex vivo cultures and in aging tissues. The problem with culturing cells
Senescent Cells and the Cytokine Storm
August 13, 2021
Research recently published in Aging shows how senescent cells overreact to inflammatory stimuli, causing them to excessively excrete compounds that promote inflammation. The researchers hypothesize that this is one cause
A New Clock Tracks Inflammatory Aging
August 12, 2021
Epigenetic clocks have become a mainstay of longevity research over the past few years, with new clocks regularly being established for different species and tissues as well as promising research
Dr. Aubrey de Grey Faces Allegations of Sexual Harassment
August 12, 2021
Early yesterday, LEAF became aware of allegations against Aubrey de Grey, the Chief Science Officer of the SENS Research Foundation, of sexual harassment. The allegations were raised by Laura Deming
Young ECM Expression in Predicting Longevity Drug Discovery
August 11, 2021
A recent study published in Aging Cell has turned up potential new therapeutics to target the aging extracellular matrix (ECM). Longevity drug discovery The discovery of new targets injects fresh
Computer Modeling Rapamycin Derivatives for Treating Stroke
August 10, 2021
In a study published in Aging, Chinese researchers have described how they used computer modeling in order to create a new rapalog that is designed to reduce the long-term impact
Humanity Launches an App to Help You Slow Down Aging
August 9, 2021
Humanity has launched a longevity app in the UK that could help you stay healthier for longer and potentially achieve longevity. The HUMANITY app has been launched on the iPhone,
The Aging Microbiome Impacts Immune Function in the Brain
August 6, 2021
Aging causes changes to the diversity and numbers of bacteria that live in our guts, and it has become a growing area of interest for researchers in recent years. The
What is Spermidine? A Summary of Spermidine
August 6, 2021
Found in grapefruit, spermidine is one of the more interesting polyamines. Some research suggests that spermidine may slow down aging and promote healthy longevity. What is spermidine? Spermidine is a
The Facts and Fiction of the Movie Old
August 5, 2021
I started to like sci-fi movies as a child, and I am still a fan. However the more I learn about science and technology, the harder it is to ignore
Collagen, Senescence, and Age-Related Hair Loss
August 25, 2021
Last week, a new study published in Aging reported similar mechanisms of TGF-ß2 and collagen on hair follicle aging, dermal papilla cell senescence, and in vitro spheroid formation. Aging hair follicles Hair follicles reside in the epidermal and dermal skin layers. At their base is the
Working the Deletion Problem out of CRISPR
August 24, 2021
In a study published in Genome Biology, researchers explain how they are working to make CRISPR less prone to large, accidental deletions of genetic material [1]. A previously unknown large problem While this seems counterintuitive, previous technology only allowed for the ready identification of deletions below
Stress, Sensory Gating, and Cognitive Decline With Age
August 23, 2021
Researchers publishing in Aging have found that stresses, both biological and in daily life, harm one of our fundamental abilities to correctly process what’s going on around us. What is sensory gating? Sensory gating is the brain’s ability to filter out irrelevant stimuli after the first
Longeveron Takes Aim at Aging with Cell Therapy
August 18, 2021
Longeveron has just announced the first data from its Phase 2b clinical trial that targets frailty with Lomecel-B, an MSC-based cell therapy. A longevity strategy built in More and more, biotech start-ups are applying longevity strategies to their therapeutic pipelines. Among them, Longeveron stands out as
The Hedgehog Protein Reduces Microglial Inflammation in Mice
August 17, 2021
Researchers, publishing in the journal Aging, have discovered that a protein called hedgehog alleviates the tissue-specific, age-related inflammation of the microglia, the maintenance cells of the brain. The aging differences between tissue types To begin this research, the team first performed a gene expression analysis on
Stem Cell Helper Heat Shock Protein Identified
August 16, 2021
Researchers publishing in Cell Stem Cell have identified a protein that helps hematopoietic stem cells (HSCs) both in ex vivo cultures and in aging tissues. The problem with culturing cells As the researchers explain, HSCs give rise to both red and white blood cells, making their
Senescent Cells and the Cytokine Storm
August 13, 2021
Research recently published in Aging shows how senescent cells overreact to inflammatory stimuli, causing them to excessively excrete compounds that promote inflammation. The researchers hypothesize that this is one cause of the cytokine storm, an immune overreaction that is more common in the elderly and is
A New Clock Tracks Inflammatory Aging
August 12, 2021
Epigenetic clocks have become a mainstay of longevity research over the past few years, with new clocks regularly being established for different species and tissues as well as promising research that uses and builds on these clocks. An international research team has recently created a different
Dr. Aubrey de Grey Faces Allegations of Sexual Harassment
August 12, 2021
Early yesterday, LEAF became aware of allegations against Aubrey de Grey, the Chief Science Officer of the SENS Research Foundation, of sexual harassment. The allegations were raised by Laura Deming (Longevity Fund) and Celine Halioua (biotech startup Loyal) – via their accounts on Twitter and personal
Young ECM Expression in Predicting Longevity Drug Discovery
August 11, 2021
A recent study published in Aging Cell has turned up potential new therapeutics to target the aging extracellular matrix (ECM). Longevity drug discovery The discovery of new targets injects fresh lifeblood into the race to develop anti-aging compounds. The strategies used to identify these targets have
Computer Modeling Rapamycin Derivatives for Treating Stroke
August 10, 2021
In a study published in Aging, Chinese researchers have described how they used computer modeling in order to create a new rapalog that is designed to reduce the long-term impact of stroke. Reperfusion injury, autophagy, and mTORC1 Stroke and other ischemic events, such as heart attack,
Humanity Launches an App to Help You Slow Down Aging
August 9, 2021
Humanity has launched a longevity app in the UK that could help you stay healthier for longer and potentially achieve longevity. The HUMANITY app has been launched on the iPhone, and it is due to get an Android version in the near future. This longevity app
The Aging Microbiome Impacts Immune Function in the Brain
August 6, 2021
Aging causes changes to the diversity and numbers of bacteria that live in our guts, and it has become a growing area of interest for researchers in recent years. The gut microbiome The gut microbiome is a constantly changing environment populated by vast numbers and types
What is Spermidine? A Summary of Spermidine
August 6, 2021
Found in grapefruit, spermidine is one of the more interesting polyamines. Some research suggests that spermidine may slow down aging and promote healthy longevity. What is spermidine? Spermidine is a polyamine, meaning it has two or more primary amino groups. It is naturally occurring and is widely
The Facts and Fiction of the Movie Old
August 5, 2021
I started to like sci-fi movies as a child, and I am still a fan. However the more I learn about science and technology, the harder it is to ignore inconsistencies and fantasy the producers present as facts in order to excite the viewer. One can