Category: Biology of Aging
Extracellular Vesicles Restore Some Heart Function to Mice
April 3, 2025
Publishing in Stem Cell Research & Therapy, researchers have found that small extracellular vesicles (sEVs) derived from young mice alleviate heart dysfunction in older mice. Reaffirming an approach These researchers
Activation of Silent X Chromosome Might Improve Cognition
April 2, 2025
Using a mouse model, researchers from UCSF have found that the genes that become activated on the silent X chromosome might explain some sex-dependent differences in cognitive abilities during aging
Scientists Discover a New Mitigator of Senescence
April 1, 2025
Working with flies, mice, and human cells, scientists have demonstrated that a highly conserved protein can modulate cellular senescence, potentially opening a new avenue for future therapies [1]. DNA damage
Changes in Aging Adrenal Glands Disturb Hormonal Balance
March 31, 2025
In the Journal of Endocrinological Investigation, reviewers have described how aging affects the adrenal glands, which has downstream effects on the rest of the human body. Small but vital This
Need for Cholesterol May Explain Alzheimer’s Brain Patterns
March 28, 2025
Some brain regions are more vulnerable to Alzheimer’s disease than others. A new study suggests that this might be due to how they uptake cholesterol [1]. Why do some parts
Researchers Find New Target for Spinal Disc Degeneration
March 27, 2025
Researchers have found a new avenue for approaching spinal disc degeneration and published their work in Aging Cell. A very common problem Back problems in the elderly are widely known
Heat May Speed Up Epigenetic Aging in Older Adults
March 26, 2025
A recent study reported significant associations between increased heat days and accelerated epigenetic aging [1]. Heat alters DNA While warm summer days on the beach are pleasant, extreme heat is
Anti-Amyloid Drug Reduces Alzheimer’s Risk in Small Subgroup
March 25, 2025
According to an open-label study from Washington University in St. Louis, the anti-amyloid drug gantenerumab reduced the risk of developing familial Alzheimer’s disease in a subgroup of participants [1]. Is
Scientists Create Cytoskeleton-Like Structures From RNA
March 21, 2025
In a new study, researchers report producing self-assembling nanotubes and rings made from RNA molecules inside artificial cell-like lipid vesicles. In the future, this technology could facilitate the creation of
A Hypothalamus Neuropeptide Reduces Aging in a Mouse Model
March 19, 2025
Researchers have improved multiple health metrics in prematurely aged mice by re-establishing the production of neuropeptide Y in the hypothalamus [1]. An essential protein Age-related decline in the function of
Short-Term Overeating Alters Brain Insulin Sensitivity
March 18, 2025
A new study published in Nature Metabolism suggests that even a short period of eating loads of sweet and fatty snacks can cause brain changes reminiscent of those seen in
Elamipretide, a Potential New Drug, Reduces Frailty in Mice
March 17, 2025
In Aging Cell, Dr. Vadim Gladyshev and a team of researchers have described how elamipretide beneficially affects mitochondrial pathways and reverses frailty in mice. A drug on its way to
Cellular Senescence Prevents Unlearning in Some Male Mice
March 13, 2025
In Aging Cell, researchers have established a link between cellular senescence and cognitive decline in unmodified male mice. Resilience versus decline The authors begin their paper by noting that cognitive
An Existing Diabetes Drug May Treat Aspects of Aging
March 10, 2025
In the Nature publication Signal Transduction and Targeted Therapy, researchers have described how glibenclamide, a drug used to treat type 2 diabetes, partially reverses epigenetic alterations and fights cellular senescence
A Klotho Gene Therapy Extends Life in Male Mice
March 6, 2025
In Molecular Therapy, a team of researchers has described how increasing the expression of a form of Klotho, a protein that has been frequently found to have rejuvenative effects, leads
Extracellular Vesicles Restore Some Heart Function to Mice
April 3, 2025
Publishing in Stem Cell Research & Therapy, researchers have found that small extracellular vesicles (sEVs) derived from young mice alleviate heart dysfunction in older mice. Reaffirming an approach These researchers note that there are a few ways to classify extracellular vesicles. Many of the earlier classifications
Activation of Silent X Chromosome Might Improve Cognition
April 2, 2025
Using a mouse model, researchers from UCSF have found that the genes that become activated on the silent X chromosome might explain some sex-dependent differences in cognitive abilities during aging [1]. XX and XY It is widely known that women live longer than men [2]. Women
Scientists Discover a New Mitigator of Senescence
April 1, 2025
Working with flies, mice, and human cells, scientists have demonstrated that a highly conserved protein can modulate cellular senescence, potentially opening a new avenue for future therapies [1]. DNA damage and senescence Imagine what would happen if the computer code in the software we use daily
Changes in Aging Adrenal Glands Disturb Hormonal Balance
March 31, 2025
In the Journal of Endocrinological Investigation, reviewers have described how aging affects the adrenal glands, which has downstream effects on the rest of the human body. Small but vital This paper begins with an in-depth description of the anatomy of the adrenal glands, which sit atop
Need for Cholesterol May Explain Alzheimer’s Brain Patterns
March 28, 2025
Some brain regions are more vulnerable to Alzheimer’s disease than others. A new study suggests that this might be due to how they uptake cholesterol [1]. Why do some parts of the brain succumb earlier? Despite decades of research and vast amounts of funding, scientists still
Researchers Find New Target for Spinal Disc Degeneration
March 27, 2025
Researchers have found a new avenue for approaching spinal disc degeneration and published their work in Aging Cell. A very common problem Back problems in the elderly are widely known to be caused by a deteriorating spine. Some of these problems are due to the vertebrae
Heat May Speed Up Epigenetic Aging in Older Adults
March 26, 2025
A recent study reported significant associations between increased heat days and accelerated epigenetic aging [1]. Heat alters DNA While warm summer days on the beach are pleasant, extreme heat is not as enjoyable, especially in daily life. It is also not healthy, since extreme heat has
Anti-Amyloid Drug Reduces Alzheimer’s Risk in Small Subgroup
March 25, 2025
According to an open-label study from Washington University in St. Louis, the anti-amyloid drug gantenerumab reduced the risk of developing familial Alzheimer’s disease in a subgroup of participants [1]. Is it about amyloid beta? Despite billions of dollars invested in developing therapies against Alzheimer’s disease, the
Scientists Create Cytoskeleton-Like Structures From RNA
March 21, 2025
In a new study, researchers report producing self-assembling nanotubes and rings made from RNA molecules inside artificial cell-like lipid vesicles. In the future, this technology could facilitate the creation of synthetic cells for various research, diagnostic, and therapeutic applications [1]. Paperless origami DNA and RNA molecules
A Hypothalamus Neuropeptide Reduces Aging in a Mouse Model
March 19, 2025
Researchers have improved multiple health metrics in prematurely aged mice by re-establishing the production of neuropeptide Y in the hypothalamus [1]. An essential protein Age-related decline in the function of the hypothalamus, a core region of the brain, has been suggested to be a “key factor
Short-Term Overeating Alters Brain Insulin Sensitivity
March 18, 2025
A new study published in Nature Metabolism suggests that even a short period of eating loads of sweet and fatty snacks can cause brain changes reminiscent of those seen in obesity and type 2 diabetes [1]. What can go wrong in five days? If you usually
Elamipretide, a Potential New Drug, Reduces Frailty in Mice
March 17, 2025
In Aging Cell, Dr. Vadim Gladyshev and a team of researchers have described how elamipretide beneficially affects mitochondrial pathways and reverses frailty in mice. A drug on its way to the clinic As a mitochondria-affecting antioxidant peptide, elamipretide has been, and continues to be, the subject
Cellular Senescence Prevents Unlearning in Some Male Mice
March 13, 2025
In Aging Cell, researchers have established a link between cellular senescence and cognitive decline in unmodified male mice. Resilience versus decline The authors begin their paper by noting that cognitive decline in older people varies greatly. Some people suffer serious cognitive defects; other people are scarcely
An Existing Diabetes Drug May Treat Aspects of Aging
March 10, 2025
In the Nature publication Signal Transduction and Targeted Therapy, researchers have described how glibenclamide, a drug used to treat type 2 diabetes, partially reverses epigenetic alterations and fights cellular senescence in mice. A system tightly tied together This paper begins with a discussion of the relationship
A Klotho Gene Therapy Extends Life in Male Mice
March 6, 2025
In Molecular Therapy, a team of researchers has described how increasing the expression of a form of Klotho, a protein that has been frequently found to have rejuvenative effects, leads to longer lifespans in male mice. Klotho has various forms In their introduction, the researchers distinguish