Category: Biology of Aging
ARDD 2023: The Mother of All Longevity Conferences
September 26, 2023
Once a year, Copenhagen becomes a Mecca for the longevity community. Hundreds of people flock to the picturesque Danish capital to attend the Aging Research and Drug Discovery Meeting (ARDD)
An Unexplored Link Between Inflammation and Alzheimer’s
September 25, 2023
An article in GeroScience describes a previously unexplored relationship between FABP7, an inflammatory molecule that binds to fatty acids, and Alzheimer’s disease. Not just a transporter Originally, as the authors
Developing a Treatment for Arthritis from Stem Cell Signals
September 22, 2023
Resarchers publishing in Aging have found that extracellular vesicles (EVs) derived from human umbilical cord mesenchymal stem cells (MSCs) reduce inflammatory markers in chondrocytes, which are responsible for building and
Creating a Noise Clock to Measure Biological Age
September 21, 2023
Publishing in Aging, the Conboy research lab has outlined the problems with existing machine learning-based clocks and created a new clock based on epigenetic noise. The problem with linear regression
Senolytics as a Potential Back Pain Treatment
September 20, 2023
In a recent paper, researchers from McGill University in Canada have investigated how a combination of two senolytics, RG-7112 and o-Vanillin, influences the intervertebral disc cells of back pain patients
Stem Cell Signals Improve Cardiac Health in Old Rats
September 18, 2023
The Journal Club returns with Dr. Oliver Medvedik on September 29th at 12:00 Eastern time on our Facebook page. We take a look at a recent study published in Nature,
Turning Back the Clock With mRNA Telomerase Therapy
September 11, 2023
Since its launch in 2016, Rejuvenation Technologies, located in Mountain View, California, has been developing a therapeutic to restore telomeres in humans. The company has been in stealth mode for
Metformin and Galantamine To Combat Muscle Loss
September 7, 2023
Researchers associated with Rejuvenate Biomed and publishing in JCI Insight have conducted multiple experiments on a combination of metformin and galantamine in animal models. These preclinical experiments are intended to
Fisetin Reduces Senescence in the Brains of Sheep
September 4, 2023
A study published in Antioxidants has found that the senolytic fisetin significantly decreases cellular senescence in the brains of sheep. A flavonoid with a long history This paper begins with
Extracellular Vesicles Improve Cardiac Health in Old Rats
September 1, 2023
In a new study published in Nature, extracellular vesicles derived from neonatal cardiac progenitors produced significant rejuvenation in old rats and human cells [1]. Tiny messengers Extracellular vesicles (EV) are
Senolytics Have Sex-Dependent Effects on Young Mice
August 30, 2023
In a research paper published in GeroScience, researchers investigated the impact of senolytics on young mice and found some surprising results [1]. Senescent cell removal and other properties Senolytics, when
Treating Enlarged Hearts in Cats with Rapamycin
August 28, 2023
Researchers publishing in Journal of the American Veterinary Medical Association have conducted a feline clinical trial finding that rapamycin is effective against heart enlargement in cats. A well-known drug for
Is Immortality Possible or Is Aging Inevitable?
August 28, 2023
“Could humans become immortal?” is something we get asked quite often, and the answer depends on what exactly you mean. When it comes to immortality, what you mean is
Utilizing One of the Naked Mole Rat’s Abilities
August 24, 2023
Publishing in Nature, a team of researchers including Vadim Gladyshev, Steve Horvath, and Vera Gorbunova has investigated the role of hyaluronan, which naked mole rats have in abundance, as a
How Spaceflight Alters the Rate of Aging
August 23, 2023
A review published in Aging Cell has explored the impact of spaceflight on human and other organisms’ health and aging [1]. Hazards of spaceflight Will sending humans to space make
ARDD 2023: The Mother of All Longevity Conferences
September 26, 2023
Once a year, Copenhagen becomes a Mecca for the longevity community. Hundreds of people flock to the picturesque Danish capital to attend the Aging Research and Drug Discovery Meeting (ARDD) for five full days of talks by geroscientists and biotech leaders, mingling and networking with like-minded
An Unexplored Link Between Inflammation and Alzheimer’s
September 25, 2023
An article in GeroScience describes a previously unexplored relationship between FABP7, an inflammatory molecule that binds to fatty acids, and Alzheimer’s disease. Not just a transporter Originally, as the authors explain, fatty acid binding proteins (FABPs) were considered to be simple biological chaperones that did not
Developing a Treatment for Arthritis from Stem Cell Signals
September 22, 2023
Resarchers publishing in Aging have found that extracellular vesicles (EVs) derived from human umbilical cord mesenchymal stem cells (MSCs) reduce inflammatory markers in chondrocytes, which are responsible for building and maintaining human cartilage. An established approach This is far from the first attempt at treating osteoarthritis
Creating a Noise Clock to Measure Biological Age
September 21, 2023
Publishing in Aging, the Conboy research lab has outlined the problems with existing machine learning-based clocks and created a new clock based on epigenetic noise. The problem with linear regression This paper begins with a description of the elastic net, an artificial intelligence algorithm that powers
Senolytics as a Potential Back Pain Treatment
September 20, 2023
In a recent paper, researchers from McGill University in Canada have investigated how a combination of two senolytics, RG-7112 and o-Vanillin, influences the intervertebral disc cells of back pain patients [1]. Back pain is a widespread issue An overwhelming majority of people, a full 80%, have
Stem Cell Signals Improve Cardiac Health in Old Rats
September 18, 2023
The Journal Club returns with Dr. Oliver Medvedik on September 29th at 12:00 Eastern time on our Facebook page. We take a look at a recent study published in Nature, in which extracellular vesicles derived from neonatal cardiac progenitors produced significant rejuvenation in old rats and
Turning Back the Clock With mRNA Telomerase Therapy
September 11, 2023
Since its launch in 2016, Rejuvenation Technologies, located in Mountain View, California, has been developing a therapeutic to restore telomeres in humans. The company has been in stealth mode for a number of years, but there is finally some news! Reversing a decade of telomere loss
Metformin and Galantamine To Combat Muscle Loss
September 7, 2023
Researchers associated with Rejuvenate Biomed and publishing in JCI Insight have conducted multiple experiments on a combination of metformin and galantamine in animal models. These preclinical experiments are intended to be a prelude to a human trial for sarcopenia. A debilitating disease with no pharmaceutical treatments
Fisetin Reduces Senescence in the Brains of Sheep
September 4, 2023
A study published in Antioxidants has found that the senolytic fisetin significantly decreases cellular senescence in the brains of sheep. A flavonoid with a long history This paper begins with an in-depth discussion of many previous experiments involving this flavonoid, which is naturally found, in small
Extracellular Vesicles Improve Cardiac Health in Old Rats
September 1, 2023
In a new study published in Nature, extracellular vesicles derived from neonatal cardiac progenitors produced significant rejuvenation in old rats and human cells [1]. Tiny messengers Extracellular vesicles (EV) are microscopic bubbles encased in the same lipid bilayer that cellular membranes are made of. EVs are
Senolytics Have Sex-Dependent Effects on Young Mice
August 30, 2023
In a research paper published in GeroScience, researchers investigated the impact of senolytics on young mice and found some surprising results [1]. Senescent cell removal and other properties Senolytics, when given to older mice, clear senescent cells. Senolytics such as fisetin and quercetin also have anti-inflammatory
Treating Enlarged Hearts in Cats with Rapamycin
August 28, 2023
Researchers publishing in Journal of the American Veterinary Medical Association have conducted a feline clinical trial finding that rapamycin is effective against heart enlargement in cats. A well-known drug for a well-known problem Rapamycin, also known as sirolimus, is one of the most well-known and commonly
Is Immortality Possible or Is Aging Inevitable?
August 28, 2023
“Could humans become immortal?” is something we get asked quite often, and the answer depends on what exactly you mean. When it comes to immortality, what you mean is important Whether human immortality is possible greatly depends on how you define it. If you define
Utilizing One of the Naked Mole Rat’s Abilities
August 24, 2023
Publishing in Nature, a team of researchers including Vadim Gladyshev, Steve Horvath, and Vera Gorbunova has investigated the role of hyaluronan, which naked mole rats have in abundance, as a protective mechanism in a mouse model. An established mechanism Naked mole rats are notably resistant to
How Spaceflight Alters the Rate of Aging
August 23, 2023
A review published in Aging Cell has explored the impact of spaceflight on human and other organisms’ health and aging [1]. Hazards of spaceflight Will sending humans to space make them age slower or faster? Will they be healthier, or will their health suffer? As space