Category: Biology of Aging
Different Tissues’ Proteins Age in Different Ways
July 14, 2022
An in-depth preprint published in bioRxiv has thoroughly described how separate tissues lose proteostasis in different ways. Segmental progeria As a model of accelerated aging, the researchers used an already
AI-Powered Novel Therapeutic Target Discovery
July 13, 2022
A new study conducted by Insilico Medicine in collaboration with leading aging research institutions has identified novel therapeutic targets for amyotrophic lateral sclerosis, a devastating age-associated neurodegenerative disease [1]. Disease
Metformin, Rapamycin, NMN, and Vascular Cognitive Impairment
July 7, 2022
A study published in Frontiers in Neurology has detailed how three well-known longevity-associated compounds affect vascular cognitive impairment (VCI) in a rat model. A rat model of a common human
Rejuvenating the Brain with Transplanted Astrocytes
July 6, 2022
A new study published in Stem Cell Research and Therapy has shown that rejuvenating the astrocyte niche in the aged brains of mice leads to improved nervous system function at
Politicians Live Longer Than Most People
July 5, 2022
By analyzing historical data, scientists have shown that politicians, an example of an elite group, have enjoyed longer than average life expectancy since about 1950 [1]. The elite lives longer
Old Human Skin Rejuvenated When Implanted in Young Mice
July 1, 2022
Publishing in Science, researchers have transplanted old human skin to young mice and witnessed a robust rejuvenation cascade that is probably triggered by vascular growth [1]. New life for old
Longevity Through Altering Essential Gene Expression
June 29, 2022
In a new study published in GeroScience, researchers have shown that it is possible to significantly increase yeast lifespan by overexpressing genes highly conserved across various species [1]. Survival and
Senolytic Helps Anti-Osteoarthritis Potential in Stem Cells
June 24, 2022
Scientists have improved the potential effectiveness of a stem cell therapy for osteoarthritis by targeting senescent cells [1]. Stem cell exhaustion and osteoarthritis Osteoarthritis is an age-related disease that affects
Stem Cells for Fighting Sarcopenia
June 23, 2022
In their publication in Stem Cell Research & Therapy, a team of researchers has shown how effective mesenchymal stromal cells (MSCs) are in a mouse model. Multipotent cells with multiple
Aspirin Affects Alzheimer’s Outcomes in Cardiac Patients
June 22, 2022
A study published in Alzheimer’s Research & Therapy has shown that low-dose aspirin affects Alzheimer’s disease and vascular dementia only in the presence of coronary heart disease. A well-known preventative
Targeting Fibrosis Reverses Ovarian Aging in Mice
June 21, 2022
Scientists have successfully treated ovarian aging in mice with compounds that target fibrosis and promote mitochondrial health [1]. Why do ovaries age faster? Ovarian aging is fascinating because one bodily
Skin Aging of the Naked Mole Rat
June 17, 2022
Naked mole rats are long-lived rodents famous for their resistance to cancer and sustained healthy lifespan. In a new study published in the Journal of Investigative Dermatology, researchers have shown
Blood Donation Slows Skin Aging in Mice
June 17, 2022
Scientists have shown that blood donation strongly affects skin aging in mice, probably by lowering the levels of toxic free iron [1]. The good bloodshed Before the dawn of modern
Dietary Restriction Delays Eye Aging in Flies
June 16, 2022
A new study published in Nature has reported on how caloric restriction, circadian rhythms, and molecular clocks interact to affect the ocular health and lifespan of fruit flies. Circadian rhythms,
Spermidine Human Trial Results Fail to Impress
June 8, 2022
The results of a human clinical trial for spermidine against cognitive decline have recently been published, but the results are not positive. What is spermidine? Spermidine is a polyamine, meaning
Different Tissues’ Proteins Age in Different Ways
July 14, 2022
An in-depth preprint published in bioRxiv has thoroughly described how separate tissues lose proteostasis in different ways. Segmental progeria As a model of accelerated aging, the researchers used an already short-lived vertebrate, the killifish, with a mutation that impairs its ability to create telomerase. This results
AI-Powered Novel Therapeutic Target Discovery
July 13, 2022
A new study conducted by Insilico Medicine in collaboration with leading aging research institutions has identified novel therapeutic targets for amyotrophic lateral sclerosis, a devastating age-associated neurodegenerative disease [1]. Disease and aging: not that different Amyotrophic lateral sclerosis (ALS) is a rare neuromuscular disease. It is
Metformin, Rapamycin, NMN, and Vascular Cognitive Impairment
July 7, 2022
A study published in Frontiers in Neurology has detailed how three well-known longevity-associated compounds affect vascular cognitive impairment (VCI) in a rat model. A rat model of a common human disease In bilateral common carotid artery occlusion (BCCAO), the arteries of rats are sutured to reduce
Rejuvenating the Brain with Transplanted Astrocytes
July 6, 2022
A new study published in Stem Cell Research and Therapy has shown that rejuvenating the astrocyte niche in the aged brains of mice leads to improved nervous system function at both the cellular and organismal levels [1]. A glia-centric approach In brain aging, neurons are quite
Politicians Live Longer Than Most People
July 5, 2022
By analyzing historical data, scientists have shown that politicians, an example of an elite group, have enjoyed longer than average life expectancy since about 1950 [1]. The elite lives longer Historical trends in health and mortality can teach us a lot about the present. It is
Old Human Skin Rejuvenated When Implanted in Young Mice
July 1, 2022
Publishing in Science, researchers have transplanted old human skin to young mice and witnessed a robust rejuvenation cascade that is probably triggered by vascular growth [1]. New life for old skin Our skin begins to age relatively early, and this conspicuous process gave rise to a
Longevity Through Altering Essential Gene Expression
June 29, 2022
In a new study published in GeroScience, researchers have shown that it is possible to significantly increase yeast lifespan by overexpressing genes highly conserved across various species [1]. Survival and aging The question of the effects of nature versus nurture, or programmed versus stochastic, sparks hot
Senolytic Helps Anti-Osteoarthritis Potential in Stem Cells
June 24, 2022
Scientists have improved the potential effectiveness of a stem cell therapy for osteoarthritis by targeting senescent cells [1]. Stem cell exhaustion and osteoarthritis Osteoarthritis is an age-related disease that affects joints by degrading cartilage. While not fatal in itself, osteoarthritis negatively affects mobility and quality of
Stem Cells for Fighting Sarcopenia
June 23, 2022
In their publication in Stem Cell Research & Therapy, a team of researchers has shown how effective mesenchymal stromal cells (MSCs) are in a mouse model. Multipotent cells with multiple uses As multipotent stem cells, MSCs can differentiate into several different cell types, including fat cells,
Aspirin Affects Alzheimer’s Outcomes in Cardiac Patients
June 22, 2022
A study published in Alzheimer’s Research & Therapy has shown that low-dose aspirin affects Alzheimer’s disease and vascular dementia only in the presence of coronary heart disease. A well-known preventative Acetylsalicylic acid, more commonly known as aspirin, is often taken at a steady, low dose of
Targeting Fibrosis Reverses Ovarian Aging in Mice
June 21, 2022
Scientists have successfully treated ovarian aging in mice with compounds that target fibrosis and promote mitochondrial health [1]. Why do ovaries age faster? Ovarian aging is fascinating because one bodily system completely shuts down while the rest of the body is still in good health. Therefore,
Skin Aging of the Naked Mole Rat
June 17, 2022
Naked mole rats are long-lived rodents famous for their resistance to cancer and sustained healthy lifespan. In a new study published in the Journal of Investigative Dermatology, researchers have shown that the skin of older members of this species is characterized by high expression of longevity-associated
Blood Donation Slows Skin Aging in Mice
June 17, 2022
Scientists have shown that blood donation strongly affects skin aging in mice, probably by lowering the levels of toxic free iron [1]. The good bloodshed Before the dawn of modern medicine, bloodletting was one of the favorite arrows in medieval doctors’ quivers. Of course, it was
Dietary Restriction Delays Eye Aging in Flies
June 16, 2022
A new study published in Nature has reported on how caloric restriction, circadian rhythms, and molecular clocks interact to affect the ocular health and lifespan of fruit flies. Circadian rhythms, clock genes, and photoreceptors The researchers begin their paper by discussing the concept of circadian rhythms,
Spermidine Human Trial Results Fail to Impress
June 8, 2022
The results of a human clinical trial for spermidine against cognitive decline have recently been published, but the results are not positive. What is spermidine? Spermidine is a polyamine, meaning it has two or more primary amino groups. It is naturally occurring and is widely encountered