Category: Biology of Aging
Dietary Fiber and Probiotics Affect Melanoma Immunotherapy
January 26, 2022
A study published in Science by Dr. Jennifer A. Wargo and her colleagues spanning multiple centers recently examined if dietary fiber and commercially available probiotics affect immunotherapy response in cancer
Meta-Analysis Discovers Goldilocks Zone for IGF-1
January 26, 2022
A new meta-analysis from Aging Cell has shown that both high and low levels of IGF-1 are related to mortality risk [1]. Insulin-like growth factor 1 (IGF-1) IGF-1 is one
Cellular Reprogramming Rejuvenates Multiple Organs in Mice
January 25, 2022
In a preprint showcased in bioRxiv, scientists have shown that a single cycle of partial cellular reprogramming can reverse multiple age-related changes in mice. Starting from a blank slate As
A Current Overview of Rejuvenation Techniques
January 24, 2022
Vadim Gladyshev and his team have published a review in Aging Cell about the current techniques and innovations in rejuvenation biotechnology, providing an overview of how these researchers see the
Telomerase Alleviates Alzheimer’s Symptoms not via Telomeres
January 21, 2022
Scientists publishing in Nature Aging have shown that telomerase reverse transcriptase slows neurodegeneration but not due to its telomere-building activity [1]. Chromosomes’ bodyguards The word “telomerase” rings a huge bell
CAR T Cells Produced in Vivo to Treat Cardiac Injury
January 21, 2022
Hosted by Dr. Oliver Medvedik, Journal Club returns on Tuesday 25th January at 12:00 Eastern and will be broadcast live on the lifespan.io Facebook page. The topic for this month
Heat Shock Protein Fights Senescence in Macular Degeneration
January 20, 2022
Researchers publishing in Experimental Eye Research have discovered that the peptide aB-crystallin can reduce the cellular senescence that affects the progression of age-related macular degeneration (AMD). What is αB-crystallin? αB-crystallin
Epigenetic Age Acceleration Is Linked to Hearing Loss
January 19, 2022
A study published in Frontiers in Aging Neuroscience examined the relationship between epigenetic age acceleration and hearing [1]. Since 1958, a team of researchers from the National Institute on Aging
Quercetin Improves Bone Regeneration in Older Rats
January 19, 2022
A new study in ACS Applied Materials and Interfaces used a combined geroscience and tissue engineering approach to regenerate bone in aged rats [1]. Replacement or rejuvenation? Too often, tissue
Fasting-Mimicking Diet Helps Fight Cancer
January 18, 2022
In the first human trial of its kind, scientists showed that a fasting-mimicking diet can work synergistically with conventional therapies in cancer patients, altering their metabolisms and reshaping their immune
OKN-007 Protects Mouse Spinal Cords
January 17, 2022
Publishing in GeroScience, a team of Oklahoma City researchers has found that a nitrone compound with a low molecular weight, OKN-007, maintains motor neuron functionality in the spinal cords of
Key Parkinson’s Protein Required for Immune Function
January 13, 2022
A study published in Cell Reports has found α-synuclein, the fundamental protein of Parkinson’s disease, to be critical in immune function. The gut-brain axis as a channel for disease Parkinson’s
The Effects of Metformin and Lifestyle on Mortality
January 12, 2022
An outcomes study conducted by the Diabetes Prevention Program (DPP) has examined the effects of lifestyle interventions and the popular diabetes drug metformin on all-cause mortality. Background The original DPP
Genetically Engineered T Cells Reduce Cardiac Fibrosis
January 11, 2022
Scientists have created genetically engineered T cells that target activated cardiac fibroblasts in a transient manner, alleviating symptoms of cardiac injury [1]. Engineered immune cells CAR T cell therapy is
New Combination Treatment Shows Promise Against Dementia
January 7, 2022
Scientists have combined the popular antibiotic rifampicin with resveratrol to create a possible preventative treatment for age-related dementias [1]. Oligomers, not plaques? Age-related dementias, such as Alzheimer’s disease, still defy
Dietary Fiber and Probiotics Affect Melanoma Immunotherapy
January 26, 2022
A study published in Science by Dr. Jennifer A. Wargo and her colleagues spanning multiple centers recently examined if dietary fiber and commercially available probiotics affect immunotherapy response in cancer patients [1]. They hypothesized that bacteria from two probiotic species would be associated with a response
Meta-Analysis Discovers Goldilocks Zone for IGF-1
January 26, 2022
A new meta-analysis from Aging Cell has shown that both high and low levels of IGF-1 are related to mortality risk [1]. Insulin-like growth factor 1 (IGF-1) IGF-1 is one of the body’s major metabolic hormones. It can have effects similar to insulin, and it mediates
Cellular Reprogramming Rejuvenates Multiple Organs in Mice
January 25, 2022
In a preprint showcased in bioRxiv, scientists have shown that a single cycle of partial cellular reprogramming can reverse multiple age-related changes in mice. Starting from a blank slate As was first shown in 2006 by a group led by Shinya Yamanaka, introduction of four transcription
A Current Overview of Rejuvenation Techniques
January 24, 2022
Vadim Gladyshev and his team have published a review in Aging Cell about the current techniques and innovations in rejuvenation biotechnology, providing an overview of how these researchers see the state of the field. The reversibility of aging The reviewers begin by discussing the connection between
Telomerase Alleviates Alzheimer’s Symptoms not via Telomeres
January 21, 2022
Scientists publishing in Nature Aging have shown that telomerase reverse transcriptase slows neurodegeneration but not due to its telomere-building activity [1]. Chromosomes’ bodyguards The word “telomerase” rings a huge bell for people who are familiar with geroscience. The primary function of this ribonucleoprotein complex (it consists
CAR T Cells Produced in Vivo to Treat Cardiac Injury
January 21, 2022
Hosted by Dr. Oliver Medvedik, Journal Club returns on Tuesday 25th January at 12:00 Eastern and will be broadcast live on the lifespan.io Facebook page. The topic for this month is the paper ‘CAR T cells produced in vivo to treat cardiac injury‘, which looks at
Heat Shock Protein Fights Senescence in Macular Degeneration
January 20, 2022
Researchers publishing in Experimental Eye Research have discovered that the peptide aB-crystallin can reduce the cellular senescence that affects the progression of age-related macular degeneration (AMD). What is αB-crystallin? αB-crystallin is a well-known heat shock protein, a family of proteins that is used in temperature regulation.
Epigenetic Age Acceleration Is Linked to Hearing Loss
January 19, 2022
A study published in Frontiers in Aging Neuroscience examined the relationship between epigenetic age acceleration and hearing [1]. Since 1958, a team of researchers from the National Institute on Aging Intramural Research program has been conducting the Baltimore Longitudinal Study of Aging (BLSA). The BLSA study
Quercetin Improves Bone Regeneration in Older Rats
January 19, 2022
A new study in ACS Applied Materials and Interfaces used a combined geroscience and tissue engineering approach to regenerate bone in aged rats [1]. Replacement or rejuvenation? Too often, tissue engineering and longevity therapeutics are viewed as competing strategies – two different paths to potentially combat
Fasting-Mimicking Diet Helps Fight Cancer
January 18, 2022
In the first human trial of its kind, scientists showed that a fasting-mimicking diet can work synergistically with conventional therapies in cancer patients, altering their metabolisms and reshaping their immune systems [1]. What happens when you fast? Fasting is shaping up to be a powerful addition
OKN-007 Protects Mouse Spinal Cords
January 17, 2022
Publishing in GeroScience, a team of Oklahoma City researchers has found that a nitrone compound with a low molecular weight, OKN-007, maintains motor neuron functionality in the spinal cords of aging mice. Prior research OKN-007 is not new in the literature. This is a nitrone compound,
Key Parkinson’s Protein Required for Immune Function
January 13, 2022
A study published in Cell Reports has found α-synuclein, the fundamental protein of Parkinson’s disease, to be critical in immune function. The gut-brain axis as a channel for disease Parkinson’s disease, which causes damage to the portion of the brain responsible for movement, is widely known
The Effects of Metformin and Lifestyle on Mortality
January 12, 2022
An outcomes study conducted by the Diabetes Prevention Program (DPP) has examined the effects of lifestyle interventions and the popular diabetes drug metformin on all-cause mortality. Background The original DPP was conducted at 27 centers in the United States from 1996 to 2001. Building upon this
Genetically Engineered T Cells Reduce Cardiac Fibrosis
January 11, 2022
Scientists have created genetically engineered T cells that target activated cardiac fibroblasts in a transient manner, alleviating symptoms of cardiac injury [1]. Engineered immune cells CAR T cell therapy is a much-touted novel technique that makes use of an organism’s own immune system. CAR stands for
New Combination Treatment Shows Promise Against Dementia
January 7, 2022
Scientists have combined the popular antibiotic rifampicin with resveratrol to create a possible preventative treatment for age-related dementias [1]. Oligomers, not plaques? Age-related dementias, such as Alzheimer’s disease, still defy current treatment options, impeding attempts to increase human lifespan. According to the theory of competing risks,