Category: Biology of Aging
Dr. Morgan Levine on Building a Better Epigenetic Clock
September 22, 2021
In her lab at Yale, Dr. Morgan Levine tackles some of the most exciting and difficult problems in geroscience. She specializes in bioinformatics and is working on creating and finessing
Senolytics Alleviate Spinal Disc Degeneration in Mice
September 21, 2021
A group of researchers has found that early long-term treatment of mice with the popular senolytic duo dasatinib and quercetin alleviates symptoms of intervertebral disc degeneration, a major age-related cause
Epigenomic Rejuvenation for Restoring Bone Stem Cells
September 17, 2021
Researchers have shown that age-related loss of bone maintenance is caused by changes in gene expression [1]. Perhaps most importantly, those changes can also be reversed and the bone marrow
Understanding How We Evolved to Age
September 16, 2021
In a paper in Frontiers in Genetics, Maël Lemoine of France’s CNRS offers an evolutionary perspective on the hallmarks of aging [1]. This review examines the appearance of the hallmarks
MoveAge: A New Movement-Based Biological Aging Clock
September 14, 2021
Researchers have developed a biological aging clock based on movement data from wearable devices. Using their clock and the same dataset, they identified a few possibly life-prolonging nutrients and drugs
Key Source of Thymic Aging Discovered
September 13, 2021
Publishing in Nature Communications’ Cell Death Discovery, a team of Chinese researchers has discovered a reason for thymic involution, the age-related decline of the thymus. The thymus and its involution
BioNTech mRNA Cancer Treatment Enters Human Trials
September 10, 2021
The current pandemic has brought mRNA vaccines into the spotlight and have likely sped up the widespread adoption and usage of this technology. Now, a company has its sights set
Boosting NANOG to Revitalize Muscle Cell Progenitors
September 9, 2021
Boosting the expression of the transcription factor NANOG reduces markers of cellular senescence in cultured muscle cells and in live mouse models, according to new research [1]. This holds out
MTOR Inhibition Leads to 30% Life Extension in Progeric Mice
September 8, 2021
Researchers have created a new mouse model for studying Hutchinson-Gilford progeria syndrome (HGPS) and achieved 30% lifespan extension in these animals by genetically downregulating mTOR [1]. HGPS: accelerated aging HGPS,
Fecal Transplantation for Alzheimer’s Disease
September 7, 2021
A recent review published in Cureus shows why fecal microbial transplantation (FMT) might be able to help sufferers of Alzheimer’s disease, showing how tightly the gut and brain are intertwined.
Altos Labs Launches with a Focus on Cellular Reprogramming
September 6, 2021
A new company focused on aging has launched, and it has the backing of Yuri Milner and Jeff Bezos among other wealthy people interested in tackling aging. Altos Labs is
A Peptide Boosts Cognition in Mouse Study
September 3, 2021
Cognitive decline and neurological aging may involve a peptide known as adropin, according to new research. The identification of this link offers a new perspective on the aging brain and
Exploring the Senescence-Associated Secretory Phenotype
September 2, 2021
Today, we want to highlight a recent review that charts the pro-inflammatory signals produced by senescent cells [1]. What is the senescence-associated secretory phenotype? As we grow older, an increasing
What are Senolytics? A Summary of Senotherapeutics
September 1, 2021
In this article we will take a look at senolytics and how they have the potential to reverse some aspects of the aging process. Senescent cells and aging As your
The Road Between Inflammation and Heart Aging
August 31, 2021
A team of Chinese researchers has outlined the cellular link between age-related inflammation (inflammaging) and the physical aging of heart muscle cells (cardiomyocytes). NLRP3 and why it matters We have
Dr. Morgan Levine on Building a Better Epigenetic Clock
September 22, 2021
In her lab at Yale, Dr. Morgan Levine tackles some of the most exciting and difficult problems in geroscience. She specializes in bioinformatics and is working on creating and finessing clocks that measure biological age. We talked with Dr. Levine about her work, the impact that
Senolytics Alleviate Spinal Disc Degeneration in Mice
September 21, 2021
A group of researchers has found that early long-term treatment of mice with the popular senolytic duo dasatinib and quercetin alleviates symptoms of intervertebral disc degeneration, a major age-related cause of disability [1]. Age-related disease with early onset Conventional wisdom says that our spines just were
Epigenomic Rejuvenation for Restoring Bone Stem Cells
September 17, 2021
Researchers have shown that age-related loss of bone maintenance is caused by changes in gene expression [1]. Perhaps most importantly, those changes can also be reversed and the bone marrow stem cells rejuvenated. Bones become weaker as we age as stem cell function declines With advancing
Understanding How We Evolved to Age
September 16, 2021
In a paper in Frontiers in Genetics, Maël Lemoine of France’s CNRS offers an evolutionary perspective on the hallmarks of aging [1]. This review examines the appearance of the hallmarks in different groups across the tree of life, with the aim of providing a comprehensive picture
MoveAge: A New Movement-Based Biological Aging Clock
September 14, 2021
Researchers have developed a biological aging clock based on movement data from wearable devices. Using their clock and the same dataset, they identified a few possibly life-prolonging nutrients and drugs [1]. I move, therefore I am Developing reliable biomarkers of aging is crucial for geroscience, since
Key Source of Thymic Aging Discovered
September 13, 2021
Publishing in Nature Communications’ Cell Death Discovery, a team of Chinese researchers has discovered a reason for thymic involution, the age-related decline of the thymus. The thymus and its involution The thymus is a boot camp for T cells. Originating from bone marrow, T (for thymus)
BioNTech mRNA Cancer Treatment Enters Human Trials
September 10, 2021
The current pandemic has brought mRNA vaccines into the spotlight and have likely sped up the widespread adoption and usage of this technology. Now, a company has its sights set on treating cancer with mRNA technology, and the initial animal data is positive. mRNA steps up
Boosting NANOG to Revitalize Muscle Cell Progenitors
September 9, 2021
Boosting the expression of the transcription factor NANOG reduces markers of cellular senescence in cultured muscle cells and in live mouse models, according to new research [1]. This holds out the hope that cells could be rejuvenated without reprogramming them to pluripotency, avoiding some of the
MTOR Inhibition Leads to 30% Life Extension in Progeric Mice
September 8, 2021
Researchers have created a new mouse model for studying Hutchinson-Gilford progeria syndrome (HGPS) and achieved 30% lifespan extension in these animals by genetically downregulating mTOR [1]. HGPS: accelerated aging HGPS, sometimes referred to just as ‘progeria’, is a rare disease that affects one in 4 to
Fecal Transplantation for Alzheimer’s Disease
September 7, 2021
A recent review published in Cureus shows why fecal microbial transplantation (FMT) might be able to help sufferers of Alzheimer’s disease, showing how tightly the gut and brain are intertwined. Why would this ever work? The gut and brain are closely linked through biochemistry, and last
Altos Labs Launches with a Focus on Cellular Reprogramming
September 6, 2021
A new company focused on aging has launched, and it has the backing of Yuri Milner and Jeff Bezos among other wealthy people interested in tackling aging. Altos Labs is founded to treat aging itself In recent months, there have been some hints but considerable secrecy
A Peptide Boosts Cognition in Mouse Study
September 3, 2021
Cognitive decline and neurological aging may involve a peptide known as adropin, according to new research. The identification of this link offers a new perspective on the aging brain and points to novel potential therapies. A newly discovered metabolic neuropeptide The adropin protein is encoded by
Exploring the Senescence-Associated Secretory Phenotype
September 2, 2021
Today, we want to highlight a recent review that charts the pro-inflammatory signals produced by senescent cells [1]. What is the senescence-associated secretory phenotype? As we grow older, an increasing number of aged cells in our body enter a state called senescence. At this point, the
What are Senolytics? A Summary of Senotherapeutics
September 1, 2021
In this article we will take a look at senolytics and how they have the potential to reverse some aspects of the aging process. Senescent cells and aging As your body ages, increasing amounts of your cells enter into a state of senescence. Senescent cells do
The Road Between Inflammation and Heart Aging
August 31, 2021
A team of Chinese researchers has outlined the cellular link between age-related inflammation (inflammaging) and the physical aging of heart muscle cells (cardiomyocytes). NLRP3 and why it matters We have previously discussed the NLRP3 inflammasome, which releases inflammatory cytokines upon exposure to irritants [1], including reactive